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Research: CANCER Folding Project #16994

Project #16994 overview

Project Summary AI Beta

This project relates to understanding how proteins fold into specific shapes. Researchers are using computer simulations to study how small changes in protein structure affect their ability to bind to targets, like cancer cells. This knowledge could help design new medicines that target specific diseases more effectively.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Prof. Vincent Voelz
Institution
Temple University

Work unit

Atoms
23,400
Core
0xa8
Status
Public
Source material

Official Project Description

These simulations are designed to test our understanding the folding mechanism of alpha-helical hairpins.

We are trying to study how disulfide cross-linkers and sequence variants affect the folding thermodynamics and kinetics of these proteins, to learn how we might better use molecular simulation methods to design effective protein binder scaffolds, for use as "affibody" cancer therapeutics, for example.

Performance data

Hardware Performance for Project 16994

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:00:20

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 7950X 16-CORE 32 26,899 860,768 AMD
2 13TH GEN CORE I9-13900KS 32 26,057 833,824 Intel
3 RYZEN 9 5900X 12-CORE 24 29,924 718,176 AMD
4 RYZEN 7 7700X 8-CORE 16 38,544 616,704 AMD
5 RYZEN 7 5800X 8-CORE 16 37,126 594,016 AMD
6 RYZEN 5 7600 6-CORE 12 44,967 539,604 AMD
7 RYZEN 9 5950X 16-CORE 32 16,426 525,632 AMD
8 12TH GEN CORE I7-12700K 20 25,322 506,440 Intel
9 RYZEN 9 3950X 16-CORE 32 15,697 502,304 AMD
10 CORE I9-14900KF 24 19,947 478,728 Intel
11 RYZEN 7 5700X 8-CORE 16 25,795 412,720 AMD
12 11TH GEN CORE I7-11700K @ 3.60GHZ 16 25,283 404,528 Intel
13 11TH GEN CORE I9-11900K @ 3.50GHZ 16 24,294 388,704 Intel
14 RYZEN 7 5800X3D 8-CORE 16 22,068 353,088 AMD
15 CORE I9-10900X CPU @ 3.70GHZ 20 15,401 308,020 Intel
16 RYZEN 5 5600 6-CORE 12 24,011 288,132 AMD
17 RYZEN 7 5700G 16 17,225 275,600 AMD
18 CORE I9-9900K CPU @ 3.60GHZ 16 17,122 273,952 Intel
19 RYZEN 7 3800X 8-CORE 16 17,087 273,392 AMD
20 RYZEN 7 5800H 16 15,794 252,704 AMD
21 RYZEN 9 3900X 12-CORE 24 10,430 250,320 AMD
22 RYZEN 5 5600X 6-CORE 12 20,485 245,820 AMD
23 CORE I9-10850K CPU @ 3.60GHZ 20 11,975 239,500 Intel
24 CORE I7-8700 CPU @ 3.20GHZ 12 19,375 232,500 Intel
25 XEON CPU E5-2650 V2 @ 2.60GHZ 32 6,716 214,912 Intel
26 XEON CPU E5-2680 V3 @ 2.50GHZ 24 8,767 210,408 Intel
27 CORE I7-9700K CPU @ 3.60GHZ 8 25,081 200,648 Intel
28 XEON W-2245 CPU @ 3.90GHZ 16 12,143 194,288 Intel
29 CORE I7-10700K CPU @ 3.80GHZ 16 12,113 193,808 Intel
30 XEON CPU E5-2690 V4 @ 2.60GHZ 28 6,684 187,152 Intel
31 CORE I7-9700 CPU @ 3.00GHZ 8 21,860 174,880 Intel
32 RYZEN 7 3700X 8-CORE 16 10,794 172,704 AMD
33 RYZEN 7 PRO 4750G 16 10,629 170,064 AMD
34 RYZEN 5 3600 6-CORE 12 13,886 166,632 AMD
35 12TH GEN CORE I9-12900K 24 5,968 143,232 Intel
36 RYZEN 7 2700X EIGHT-CORE 16 8,565 137,040 AMD
37 APPLE M1 MAX 10 13,465 134,650 Apple
38 CORE I7-5930K CPU @ 3.50GHZ 12 10,042 120,504 Intel
39 XEON GOLD 6128 CPU @ 3.40GHZ 12 9,997 119,964 Intel
40 CORE I7-6800K CPU @ 3.40GHZ 12 9,291 111,492 Intel
41 RYZEN 5 2600X SIX-CORE 12 8,988 107,856 AMD
42 CORE I7-10700T CPU @ 2.00GHZ 16 6,655 106,480 Intel
43 11TH GEN CORE I5-11400 @ 2.60GHZ 12 8,765 105,180 Intel
44 CORE I7-8705G CPU @ 3.10GHZ 8 11,073 88,584 Intel
45 CORE I7-5820K CPU @ 3.30GHZ 12 7,249 86,988 Intel
46 RYZEN 5 1600 SIX-CORE 12 7,068 84,816 AMD
47 XEON CPU E3-1270 V5 @ 3.60GHZ 8 10,435 83,480 Intel
48 CORE I7-4790K CPU @ 4.00GHZ 8 10,144 81,152 Intel
49 CORE I7-4790 CPU @ 3.60GHZ 8 9,698 77,584 Intel
50 XEON CPU E5-2670 0 @ 2.60GHZ 32 2,369 75,808 Intel
51 XEON W-10855M CPU @ 2.80GHZ 12 6,307 75,684 Intel
52 APPLE M1 8 7,966 63,728 Apple
53 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 7,705 61,640 Intel
54 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,259 58,072 Intel
55 CORE I7-6700K CPU @ 4.00GHZ 8 6,945 55,560 Intel
56 XEON CPU E3-1245 V3 @ 3.40GHZ 8 6,656 53,248 Intel
57 CORE I7-4790T CPU @ 2.70GHZ 8 6,399 51,192 Intel
58 CORE I7-8700K CPU @ 3.70GHZ 12 4,098 49,176 Intel
59 CORE I5-9300H CPU @ 2.40GHZ 8 6,141 49,128 Intel
60 APPLE M1 PRO 10 4,855 48,550 Apple
61 CORE I7-7700HQ CPU @ 2.80GHZ 8 5,408 43,264 Intel
62 11TH GEN CORE I7-1165G7 @ 2.80GHZ 8 5,329 42,632 Intel
63 CORE I7-8665U CPU @ 1.90GHZ 8 5,019 40,152 Intel
64 XEON CPU E5-2697 V2 @ 2.70GHZ 24 1,298 31,152 Intel
65 CORE I5-10210U CPU @ 1.60GHZ 7 2,992 20,944 Intel
66 CORE I7-2760QM CPU @ 2.40GHZ 8 2,489 19,912 Intel
67 11TH GEN CORE I3-1125G4 @ 2.00GHZ 8 2,476 19,808 Intel