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Research: CANCER Folding Project #16931

Project #16931 overview

Project Summary AI Beta

This project relates to understanding how small proteins fold into specific shapes. By changing the protein's building blocks and connections, scientists can see how this affects its stability and folding speed. The goal is to learn how to design these proteins as 'affibody' cancer drugs that bind specifically to tumors.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Prof. Vincent Voelz
Institution
Temple University

Work unit

Atoms
23,400
Core
GRO_A8
Status
Public
Source material

Official Project Description

These simulations are designed to test our understanding the folding mechanism of alpha-helical hairpins.

We are trying to study how disulfide cross-linkers and sequence variants affect the folding thermodynamics and kinetics of these proteins, to learn how we might better use molecular simulation methods to design effective protein binder scaffolds, for use as "affibody" cancer therapeutics, for example.

Performance data

Hardware Performance for Project 16931

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:01:01

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 10,897 523,056 AMD
2 RYZEN 9 3900XT 12-CORE 24 19,510 468,240 AMD
3 CORE I9-9900K CPU @ 3.60GHZ 16 24,236 387,776 Intel
4 RYZEN 9 5950X 16-CORE 32 8,741 279,712 AMD
5 RYZEN 9 5900X 12-CORE 24 11,245 269,880 AMD
6 RYZEN 9 3950X 16-CORE 32 7,684 245,888 AMD
7 RYZEN 9 3900X 12-CORE 24 9,147 219,528 AMD
8 RYZEN THREADRIPPER 2970WX 24-CORE 48 4,446 213,408 AMD
9 RYZEN 7 5800X 8-CORE 16 13,073 209,168 AMD
10 CORE I9-7920X CPU @ 2.90GHZ 24 8,369 200,856 Intel
11 CORE I7-5960X CPU @ 3.00GHZ 16 10,291 164,656 Intel
12 CORE I9-10900K CPU @ 3.70GHZ 20 8,191 163,820 Intel
13 XEON PLATINUM 8124M CPU @ 3.00GHZ 36 4,281 154,116 Intel
14 RYZEN 7 3700X 8-CORE 16 9,210 147,360 AMD
15 XEON CPU E5-2690 V2 @ 3.00GHZ 20 7,225 144,500 Intel
16 CORE I7-9700K CPU @ 3.60GHZ 8 18,014 144,112 Intel
17 RYZEN 5 3600 6-CORE 12 11,987 143,844 AMD
18 CORE I7-9700 CPU @ 3.00GHZ 8 17,670 141,360 Intel
19 RYZEN 5 2600X SIX-CORE 12 11,522 138,264 AMD
20 RYZEN 5 3600X 6-CORE 12 11,396 136,752 AMD
21 RYZEN 7 2700X EIGHT-CORE 16 8,203 131,248 AMD
22 RYZEN 7 4800H 16 7,810 124,960 AMD
23 RYZEN 5 3500 6-CORE 6 20,688 124,128 AMD
24 RYZEN 5 3600XT 6-CORE 12 9,560 114,720 AMD
25 RYZEN 3 3100 4-CORE 8 13,610 108,880 AMD
26 RYZEN THREADRIPPER 1920X 12-CORE 24 4,391 105,384 AMD
27 CORE I5-9600K CPU @ 3.70GHZ 6 15,813 94,878 Intel
28 CORE I5-9400F CPU @ 2.90GHZ 6 15,520 93,120 Intel
29 CORE2 DUO CPU T7700 @ 2.40GHZ 12 7,717 92,604 Intel
30 CORE I7-4910MQ CPU @ 2.90GHZ 8 11,465 91,720 Intel
31 RYZEN 7 4800HS 16 5,579 89,264 AMD
32 CORE I7-8700K CPU @ 3.70GHZ 12 7,246 86,952 Intel
33 RYZEN 7 1700 EIGHT-CORE 16 5,295 84,720 AMD
34 CORE I7-3840QM CPU @ 2.80GHZ 8 10,089 80,712 Intel
35 CORE I7-6820HQ CPU @ 2.70GHZ 8 10,028 80,224 Intel
36 RYZEN 5 4600HS 12 6,466 77,592 AMD
37 CORE I7-4790K CPU @ 4.00GHZ 8 8,157 65,256 Intel
38 CORE I7-8705G CPU @ 3.10GHZ 8 7,988 63,904 Intel
39 XEON CPU E5-2620 V2 @ 2.10GHZ 24 2,641 63,384 Intel
40 CORE I7-5820K CPU @ 3.30GHZ 12 5,194 62,328 Intel
41 RYZEN 5 2600 SIX-CORE 12 5,076 60,912 AMD
42 CORE I7-8550U CPU @ 1.80GHZ 8 7,387 59,096 Intel
43 CORE I7-6800K CPU @ 3.40GHZ 12 4,896 58,752 Intel
44 CORE I5-7600 CPU @ 3.50GHZ 4 13,695 54,780 Intel
45 XEON W-2123 CPU @ 3.60GHZ 8 6,792 54,336 Intel
46 CORE I5-6500 CPU @ 3.20GHZ 4 13,526 54,104 Intel
47 CORE I3-8100 CPU @ 3.60GHZ 4 12,849 51,396 Intel
48 CORE I7-6700K CPU @ 4.00GHZ 8 5,864 46,912 Intel
49 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 5,760 46,080 Intel
50 CORE I7-2600K CPU @ 3.40GHZ 8 5,682 45,456 Intel
51 CORE I7-3770 CPU @ 3.40GHZ 8 5,022 40,176 Intel
52 XEON CPU E5-2609 V2 @ 2.50GHZ 8 4,839 38,712 Intel
53 XEON CPU E3-1230 V2 @ 3.30GHZ 8 4,658 37,264 Intel
54 CORE I7-6700 CPU @ 3.40GHZ 8 4,550 36,400 Intel
55 CORE I7-8565U CPU @ 1.80GHZ 8 4,177 33,416 Intel
56 RYZEN 7 4700U 8 3,857 30,856 AMD
57 CORE I5-2500K CPU @ 3.30GHZ 4 6,104 24,416 Intel
58 PHENOM II X6 1090T 6 3,871 23,226 AMD
59 CORE I7-6700HQ CPU @ 2.60GHZ 8 2,679 21,432 Intel
60 CORE I5-2400S CPU @ 2.50GHZ 4 4,886 19,544 Intel
61 FX-9590 EIGHT-CORE 8 2,326 18,608 AMD
62 CORE I7-2760QM CPU @ 2.40GHZ 8 2,066 16,528 Intel
63 CORE I3-7100 CPU @ 3.90GHZ 4 3,925 15,700 Intel
64 FX-8320 EIGHT-CORE 8 1,676 13,408 AMD
65 PENTIUM(R) SILVER N5000 CPU @ 1.10GHZ 4 3,052 12,208 Intel
66 PHENOM II X4 965 4 2,918 11,672 AMD
67 CORE I3-6006U CPU @ 2.00GHZ 4 2,723 10,892 Intel
68 XEON CPU L5420 @ 2.50GHZ 4 2,277 9,108 Intel
69 CELERON(R) CPU G3900 @ 2.80GHZ 2 3,996 7,992 Intel
70 CELERON(R) CPU G550 @ 2.60GHZ 2 1,101 2,202 Intel
71 A8-6410 APU 4 248 992 AMD