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Research: CANCER Folding Project #16943

Project #16943 overview

Project Summary AI Beta

This project relates to understanding how tiny proteins called hairpins fold and how changes in their structure affect how they work. The goal is to use computer simulations to design better protein 'binders' that could be used as cancer treatments.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Prof. Vincent Voelz
Institution
Temple University

Work unit

Atoms
23,400
Core
GRO_A8
Status
Public
Source material

Official Project Description

These simulations are designed to test our understanding the folding mechanism of alpha-helical hairpins.

We are trying to study how disulfide cross-linkers and sequence variants affect the folding thermodynamics and kinetics of these proteins, to learn how we might better use molecular simulation methods to design effective protein binder scaffolds, for use as "affibody" cancer therapeutics, for example.

Performance data

Hardware Performance for Project 16943

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:00:56

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 3950X 16-CORE 32 24,425 781,600 AMD
2 RYZEN 9 5950X 16-CORE 32 15,985 511,520 AMD
3 CORE I9-9980XE CPU @ 3.00GHZ 36 11,790 424,440 Intel
4 RYZEN 9 5900X 12-CORE 24 17,627 423,048 AMD
5 RYZEN THREADRIPPER 3960X 24-CORE 48 8,275 397,200 AMD
6 RYZEN THREADRIPPER 2970WX 24-CORE 48 8,108 389,184 AMD
7 CORE I9-10900K CPU @ 3.70GHZ 20 18,994 379,880 Intel
8 RYZEN 9 3900X 12-CORE 24 13,717 329,208 AMD
9 EPYC 7302P 16-CORE 32 10,007 320,224 AMD
10 RYZEN 7 5800X 8-CORE 16 18,302 292,832 AMD
11 CORE I9-7920X CPU @ 2.90GHZ 24 11,509 276,216 Intel
12 CORE I7-9700K CPU @ 3.60GHZ 8 29,055 232,440 Intel
13 RYZEN 7 3700X 8-CORE 16 13,549 216,784 AMD
14 RYZEN 7 3800X 8-CORE 16 12,860 205,760 AMD
15 CORE I7-8700K CPU @ 3.70GHZ 12 16,348 196,176 Intel
16 RYZEN 5 3600 6-CORE 12 14,563 174,756 AMD
17 CORE2 DUO CPU T7700 @ 2.40GHZ 12 13,953 167,436 Intel
18 RYZEN 7 2700X EIGHT-CORE 16 9,524 152,384 AMD
19 CORE I5-10400F CPU @ 2.90GHZ 12 10,952 131,424 Intel
20 RYZEN 7 1700 EIGHT-CORE 16 7,797 124,752 AMD
21 CORE I5-9400F CPU @ 2.90GHZ 6 20,570 123,420 Intel
22 RYZEN THREADRIPPER 1920X 12-CORE 24 4,879 117,096 AMD
23 RYZEN 5 2600X SIX-CORE 12 9,295 111,540 AMD
24 RYZEN 5 2600 SIX-CORE 12 8,992 107,904 AMD
25 CORE I5-9300H CPU @ 2.40GHZ 8 10,804 86,432 Intel
26 XEON CPU E5-2620 V2 @ 2.10GHZ 24 3,334 80,016 Intel
27 CORE I7-6700K CPU @ 4.00GHZ 8 9,619 76,952 Intel
28 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 8,687 69,496 Intel
29 CORE I7-6700 CPU @ 3.40GHZ 8 8,534 68,272 Intel
30 CORE I5-8250U CPU @ 1.60GHZ 8 5,735 45,880 Intel