alpha-helical
A type of protein structure characterized by a spiral shape.
Technical: BiopharmaceuticalsBiotechnology / Protein Structure
Alpha-helices are common structural motifs in proteins. They consist of a polypeptide chain that coils into a right-handed helix stabilized by hydrogen bonds between amino acids spaced four residues apart.
disulfide cross-linkers
Covalent bonds between cysteine amino acids in proteins.
Technical: BiopharmaceuticalsBiotechnology / Protein Structure
Disulfide cross-linkers are covalent bonds formed between sulfur atoms of two cysteine amino acids within a protein. These bonds contribute to the stability and folding of proteins.
sequence variants
Variations in the DNA sequence of a gene.
Technical: BiopharmaceuticalsBiotechnology / Genetic Engineering
Sequence variants are alterations in the order of nucleotides within a gene. These variations can lead to changes in protein structure and function.
folding thermodynamics
The study of energy changes associated with protein folding.
Technical: BiopharmaceuticalsBiotechnology / Protein Structure
Folding thermodynamics investigates the energy changes that occur when a protein folds into its native conformation. This involves factors such as enthalpy and entropy.
molecular simulation
Computer-based modeling of biological systems.
Technical: BiopharmaceuticalsBiotechnology / Computational Biology
Molecular simulations use computational algorithms to model the behavior of atoms and molecules. These simulations can be used to study protein folding, drug binding, and other biomolecular processes.
protein binder scaffolds
Structural frameworks for binding to target molecules.
Technical: BiopharmaceuticalsBiotechnology / Drug Discovery
Protein binder scaffolds are designed to specifically bind to target proteins or other biomolecules. These scaffolds can be used as the basis for therapeutic antibodies and other drug candidates.
affibody
A type of small protein scaffold that binds to specific targets.
Technical: BiopharmaceuticalsBiotechnology / Drug Discovery
Affibody is a registered trademark for a class of engineered proteins that bind tightly and specifically to their target molecules. They are used as imaging agents, therapeutic antibodies, and diagnostic tools.
cancer therapeutics
Drugs used to treat cancer.
Technical: BiopharmaceuticalsBiotechnology / Oncology
Cancer therapeutics are medications designed to kill or inhibit the growth of cancerous cells. They can work by targeting specific molecules involved in cancer cell growth and survival.