Folding project #17435, MYOSINS research

Research section Research projects and references

Project #17435 overview

Project Summary AI Beta

This project studies myosins, proteins crucial for body movement like muscle contraction. Scientists aim to understand how drugs could treat heart conditions caused by myosin defects, like cardiomyopathies and heart failure.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 288,449
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Myosins

Proteins responsible for force generation in the body.

Scientific: MedicineBiotechnology / Molecular Biology

Myosins are a family of proteins crucial for various cellular functions. They are responsible for muscle contraction, movement within cells, and other processes requiring force. Defects in myosin can lead to diseases like cardiomyopathies and heart failure.

Cardiomyopathies

Diseases affecting the heart muscle.

Medical: HealthcareMedicine / Cardiology

Cardiomyopathies are a group of conditions that weaken or stiffen the heart muscle. This can lead to problems with pumping blood effectively, causing symptoms like shortness of breath, fatigue, and chest pain. Types include hypertrophic cardiomyopathy (thickened heart muscle), dilated cardiomyopathy (enlarged heart chambers), and restrictive cardiomyopathy (stiff heart muscle).

Heart Failure

A chronic condition where the heart can't pump blood effectively.

Medical: HealthcareMedicine / Cardiology

Heart failure occurs when the heart muscle weakens and struggles to pump enough blood to meet the body's needs. This can lead to fluid buildup in the lungs and other organs, causing symptoms like shortness of breath, fatigue, and swelling. Heart failure is often a consequence of other heart conditions like cardiomyopathies or high blood pressure.

PDB

Protein Data Bank

Acronym: ResearchBiotechnology / Structural Biology

The Protein Data Bank (PDB) is a global repository for 3D structural data of biological macromolecules, primarily proteins and nucleic acids. Researchers use this database to understand protein function, design drugs, and study diseases.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,397,495	416,656	15.35	1 ^hrs 34 ^mins
2	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	5,342,191	379,413	14.08	1 ^hrs 42 ^mins
3	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,021,469	386,095	13.01	1 ^hrs 51 ^mins
4	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	4,913,741	382,999	12.83	1 ^hrs 52 ^mins
5	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	4,698,629	378,514	12.41	1 ^hrs 56 ^mins
6	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,466,494	372,606	11.99	2 ^hrs 0 ^mins
7	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	3,874,635	354,551	10.93	2 ^hrs 12 ^mins
8	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,687,600	343,095	10.75	2 ^hrs 14 ^mins
9	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,487,724	341,678	10.21	2 ^hrs 21 ^mins
10	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	2,967,691	325,343	9.12	2 ^hrs 38 ^mins
11	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,890,449	321,930	8.98	2 ^hrs 40 ^mins
12	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	2,748,997	314,750	8.73	2 ^hrs 45 ^mins
13	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,571,860	310,345	8.29	2 ^hrs 54 ^mins
14	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,541,045	309,213	8.22	2 ^hrs 55 ^mins
15	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,492,607	305,331	8.16	2 ^hrs 56 ^mins
16	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,458,038	305,670	8.04	2 ^hrs 59 ^mins
17	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,412,928	303,808	7.94	3 ^hrs 1 ^mins
18	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,248,458	296,330	7.59	3 ^hrs 10 ^mins
19	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,159,807	292,611	7.38	3 ^hrs 15 ^mins

20	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,150,219	291,287	7.38	3 ^hrs 15 ^mins
21	GeForce RTX 2080 SUPER Mobile / Max-Q TU104M [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104M	1,995,746	285,857	6.98	3 ^hrs 26 ^mins
22	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	1,991,089	285,742	6.97	3 ^hrs 27 ^mins
23	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,974,279	282,331	6.99	3 ^hrs 26 ^mins
24	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	1,956,568	282,819	6.92	3 ^hrs 28 ^mins
25	Radeon RX 6700/6700 XT / 6800M Navi 22 [Radeon RX 6700/6700 XT / 6800M]	AMD	Navi 22	1,846,321	268,047	6.89	3 ^hrs 29 ^mins
26	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,740,437	272,796	6.38	3 ^hrs 46 ^mins
27	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,668,654	268,263	6.22	3 ^hrs 52 ^mins
28	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,595,111	261,080	6.11	3 ^hrs 56 ^mins
29	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,567,781	247,222	6.34	3 ^hrs 47 ^mins
30	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,297,907	246,705	5.26	4 ^hrs 34 ^mins
31	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	1,246,487	241,569	5.16	4 ^hrs 39 ^mins
32	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	1,182,120	239,937	4.93	4 ^hrs 52 ^mins
33	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,182,025	231,249	5.11	4 ^hrs 42 ^mins
34	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,169,696	237,484	4.93	4 ^hrs 52 ^mins
35	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,159,687	237,695	4.88	4 ^hrs 55 ^mins
36	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,111,080	219,610	5.06	4 ^hrs 45 ^mins
37	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,093,946	232,734	4.70	5 ^hrs 6 ^mins
38	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,070,845	232,131	4.61	5 ^hrs 12 ^mins
39	Quadro P5000 GP104GL [Quadro P5000]	Nvidia	GP104GL	1,028,617	228,285	4.51	5 ^hrs 20 ^mins

40	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	1,018,571	227,798	4.47	5 ^hrs 22 ^mins
41	GeForce RTX 3070 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	1,009,772	227,340	4.44	5 ^hrs 24 ^mins
42	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	969,266	224,034	4.33	5 ^hrs 33 ^mins
43	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	928,480	214,697	4.32	5 ^hrs 33 ^mins
44	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	879,151	215,065	4.09	5 ^hrs 52 ^mins
45	P104-100 GP104 [P104-100]	Nvidia	GP104	738,308	204,802	3.60	6 ^hrs 39 ^mins
46	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	704,392	201,645	3.49	6 ^hrs 52 ^mins
47	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	677,415	199,406	3.40	7 ^hrs 4 ^mins
48	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	675,233	198,761	3.40	7 ^hrs 4 ^mins
49	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	618,210	190,691	3.24	7 ^hrs 24 ^mins
50	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	597,933	190,996	3.13	7 ^hrs 40 ^mins
51	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	575,660	185,706	3.10	7 ^hrs 45 ^mins
52	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	552,273	184,724	2.99	8 ^hrs 2 ^mins
53	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	549,448	184,811	2.97	8 ^hrs 4 ^mins
54	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	507,057	180,605	2.81	8 ^hrs 33 ^mins
55	P106-100 GP106 [P106-100]	Nvidia	GP106	480,203	177,605	2.70	8 ^hrs 53 ^mins
56	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	477,659	175,598	2.72	8 ^hrs 49 ^mins
57	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	447,108	173,178	2.58	9 ^hrs 18 ^mins
58	Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q]	Nvidia	TU117GLM	442,255	172,346	2.57	9 ^hrs 21 ^mins
59	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	423,900	160,863	2.64	9 ^hrs 6 ^mins

60	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	409,639	135,764	3.02	7 ^hrs 57 ^mins
61	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	359,852	159,482	2.26	10 ^hrs 38 ^mins
62	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	320,800	155,359	2.06	11 ^hrs 37 ^mins
63	P106-090 GP106 [P106-090]	Nvidia	GP106	299,041	151,704	1.97	12 ^hrs 11 ^mins
64	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	296,219	151,273	1.96	12 ^hrs 15 ^mins
65	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	276,552	147,720	1.87	12 ^hrs 49 ^mins
66	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	251,790	143,128	1.76	13 ^hrs 39 ^mins
67	Radeon RX Vega M XL [Radeon RX Vega M XL]	AMD	Vega	218,685	133,466	1.64	14 ^hrs 39 ^mins
68	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	205,096	134,485	1.53	15 ^hrs 44 ^mins
69	Radeon R9 200 Series Hawaii [Radeon R9 200 Series]	AMD	Hawaii	194,935	127,743	1.53	15 ^hrs 44 ^mins
70	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	171,225	122,204	1.40	17 ^hrs 8 ^mins
71	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	158,781	122,878	1.29	18 ^hrs 34 ^mins
72	GeForce GTX 660 GK106 [GeForce GTX 660]	Nvidia	GK106	154,140	121,759	1.27	18 ^hrs 57 ^mins
73	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	144,501	119,168	1.21	19 ^hrs 48 ^mins
74	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	142,400	118,600	1.20	19 ^hrs 59 ^mins
75	Radeon RX 460 Baffin XT [Radeon RX 460]	AMD	Baffin XT	142,169	117,568	1.21	19 ^hrs 51 ^mins
76	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	141,009	116,664	1.21	19 ^hrs 51 ^mins
77	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	126,262	111,029	1.14	21 ^hrs 6 ^mins
78	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	114,835	110,440	1.04	23 ^hrs 5 ^mins
79	GTX 650 Ti Boost GK106 [GTX 650 Ti Boost]	Nvidia	GK106	110,648	107,058	1.03	23 ^hrs 13 ^mins

80	GeForce MX150 GP108 [GeForce MX150]	Nvidia	GP108	105,867	105,028	1.01	23 ^hrs 49 ^mins
81	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	101,854	105,885	0.96	24 ^hrs 57 ^mins
82	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	98,756	104,948	0.94	25 ^hrs 30 ^mins
83	GeForce GTX 760 GK104 [GeForce GTX 760] 2258	Nvidia	GK104	81,223	98,110	0.83	28 ^hrs 59 ^mins
84	Radeon R7/R6 360 Series Bonaire [Radeon R7/R6 360 Series]	AMD	Bonaire	64,989	87,900	0.74	32 ^hrs 28 ^mins
85	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	43,364	58,804	0.74	32 ^hrs 33 ^mins
86	Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902]	AMD	raven	39,675	58,121	0.68	35 ^hrs 9 ^mins
87	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	35,364	64,653	0.55	43 ^hrs 53 ^mins
88	Quadro P400 GP107GL [Quadro P400] 641	Nvidia	GP107GL	25,869	56,000	0.46	51 ^hrs 57 ^mins
89	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	23,328	56,000	0.42	57 ^hrs 37 ^mins
90	GeForce MX110 GM108M [GeForce MX110]	Nvidia	GM108M	21,175	56,000	0.38	63 ^hrs 28 ^mins
91	GeForce GTX 670M GF114 [GeForce GTX 670M]	Nvidia	GF114	17,114	56,000	0.31	78 ^hrs 32 ^mins
92	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	6,189	56,000	0.11	217 ^hrs 10 ^mins

Research: MYOSINS Folding Project #17435

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17435

GPU PPD Averages

Research: MYOSINS Folding Project #17435

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages