Folding project #17434, MYOSINS research

Research section Research projects and references

Project #17434 overview

Project Summary AI Beta

This project studies myosins, proteins that power muscle contractions and cell movement. Scientists want to understand how drugs can fix problems with myosin, like those causing heart conditions. Myosin is so important it was even featured as the Molecule of the Month!

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 196,647
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Myosins

Proteins responsible for force generation in cells and muscles.

Scientific: Biomedical ResearchBiotechnology / Cellular Biology

Myosins are a family of proteins crucial for movement within our bodies. They power muscle contractions, allowing us to walk, run, and lift objects. They also help transport materials inside cells, ensuring essential processes like growth and repair can occur.

Proteins

Large biomolecules essential for all living organisms.

Scientific: Biomedical ResearchBiotechnology / Molecular Biology

Proteins are the building blocks of life. They perform a vast array of functions within our bodies, from catalyzing chemical reactions to transporting molecules and providing structural support. Their unique shapes and properties allow them to carry out these diverse tasks.

Muscle Contraction

The process of muscle fibers shortening to generate force.

Scientific: HealthcareBiotechnology / Physiology

Muscle contraction is the coordinated action of proteins within muscle cells that allows for movement. This intricate process involves chemical signals and energy transfer to shorten muscle fibers, ultimately enabling us to walk, run, lift objects, and perform countless other actions.

Cardiomyopathy

A disease of the heart muscle.

Medical: PharmaceuticalsHealthcare / Cardiology

Cardiomyopathy refers to a group of conditions that affect the heart muscle, making it harder for the heart to pump blood effectively. This can lead to symptoms such as fatigue, shortness of breath, and swelling in the legs or ankles.

Heart Failure

A condition in which the heart cannot pump enough blood to meet the body's needs.

Medical: PharmaceuticalsHealthcare / Cardiology

Heart failure occurs when the heart muscle weakens and can no longer effectively pump blood throughout the body. This can result in a buildup of fluid in the lungs and other tissues, leading to symptoms such as shortness of breath, fatigue, and swelling.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,175,225	239,005	25.84	0 ^hrs 56 ^mins
2	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	5,371,550	229,204	23.44	1 ^hrs 1 ^mins
3	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,096,608	225,635	22.59	1 ^hrs 4 ^mins
4	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	4,761,367	221,767	21.47	1 ^hrs 7 ^mins
5	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,465,548	216,899	20.59	1 ^hrs 10 ^mins
6	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,530,061	201,538	17.52	1 ^hrs 22 ^mins
7	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,522,603	201,253	17.50	1 ^hrs 22 ^mins
8	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,478,420	198,819	17.50	1 ^hrs 22 ^mins
9	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,061,183	190,861	16.04	1 ^hrs 30 ^mins
10	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,925,525	188,538	15.52	1 ^hrs 33 ^mins
11	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	2,841,643	184,744	15.38	1 ^hrs 34 ^mins
12	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,674,158	183,043	14.61	1 ^hrs 39 ^mins
13	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,638,649	182,116	14.49	1 ^hrs 39 ^mins
14	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,583,499	180,926	14.28	1 ^hrs 41 ^mins
15	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,453,328	177,453	13.83	1 ^hrs 44 ^mins
16	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,394,624	176,619	13.56	1 ^hrs 46 ^mins
17	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,233,865	171,988	12.99	1 ^hrs 51 ^mins
18	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,069,956	168,297	12.30	1 ^hrs 57 ^mins
19	GeForce RTX 2080 SUPER Mobile / Max-Q TU104M [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104M	2,021,202	167,497	12.07	1 ^hrs 59 ^mins

20	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	2,010,224	165,217	12.17	1 ^hrs 58 ^mins
21	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	1,834,886	161,907	11.33	2 ^hrs 7 ^mins
22	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	1,834,165	161,502	11.36	2 ^hrs 7 ^mins
23	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,668,745	156,347	10.67	2 ^hrs 15 ^mins
24	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,649,688	155,535	10.61	2 ^hrs 16 ^mins
25	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,615,716	154,582	10.45	2 ^hrs 18 ^mins
26	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,428,841	149,201	9.58	2 ^hrs 30 ^mins
27	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,286,285	142,697	9.01	2 ^hrs 40 ^mins
28	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,194,883	139,947	8.54	2 ^hrs 49 ^mins
29	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	1,172,853	139,686	8.40	2 ^hrs 52 ^mins
30	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,163,264	129,303	9.00	2 ^hrs 40 ^mins
31	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,092,422	130,027	8.40	2 ^hrs 51 ^mins
32	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,069,213	132,756	8.05	2 ^hrs 59 ^mins
33	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,061,192	134,453	7.89	3 ^hrs 2 ^mins
34	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,046,247	134,609	7.77	3 ^hrs 5 ^mins
35	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	990,222	131,704	7.52	3 ^hrs 12 ^mins
36	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	962,787	128,907	7.47	3 ^hrs 13 ^mins
37	Radeon Vega Frontier Edition Vega 10 XTX [Radeon Vega Frontier Edition]	AMD	Vega 10 XTX	925,641	128,292	7.22	3 ^hrs 20 ^mins
38	GeForce GTX 1070 Mobile GP104M [GeForce GTX 1070 Mobile]	Nvidia	GP104M	917,004	127,986	7.16	3 ^hrs 21 ^mins
39	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	872,579	125,855	6.93	3 ^hrs 28 ^mins

40	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	744,629	119,879	6.21	3 ^hrs 52 ^mins
41	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	710,950	112,721	6.31	3 ^hrs 48 ^mins
42	P104-100 GP104 [P104-100]	Nvidia	GP104	686,824	116,808	5.88	4 ^hrs 5 ^mins
43	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	684,521	116,689	5.87	4 ^hrs 5 ^mins
44	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	567,583	108,396	5.24	4 ^hrs 35 ^mins
45	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	566,588	109,330	5.18	4 ^hrs 38 ^mins
46	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	552,671	108,336	5.10	4 ^hrs 42 ^mins
47	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	483,378	103,334	4.68	5 ^hrs 8 ^mins
48	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	481,735	90,329	5.33	4 ^hrs 30 ^mins
49	P106-100 GP106 [P106-100]	Nvidia	GP106	478,713	103,530	4.62	5 ^hrs 11 ^mins
50	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	477,809	98,402	4.86	4 ^hrs 57 ^mins
51	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	455,221	101,854	4.47	5 ^hrs 22 ^mins
52	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	450,366	101,345	4.44	5 ^hrs 24 ^mins
53	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	441,927	79,645	5.55	4 ^hrs 20 ^mins
54	Radeon Pro Vega 48 Vega 10 Pro [Radeon Pro Vega 48]	AMD	Vega 10 Pro	425,781	99,533	4.28	5 ^hrs 37 ^mins
55	Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q]	Nvidia	TU117GLM	399,615	91,367	4.37	5 ^hrs 29 ^mins
56	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	398,883	96,081	4.15	5 ^hrs 47 ^mins
57	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	389,202	91,189	4.27	5 ^hrs 37 ^mins
58	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	382,689	96,090	3.98	6 ^hrs 2 ^mins
59	GeForce GTX 780 GK110 [GeForce GTX 780] 3977	Nvidia	GK110	372,275	95,048	3.92	6 ^hrs 8 ^mins

60	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	358,142	91,711	3.91	6 ^hrs 9 ^mins
61	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	324,196	91,161	3.56	6 ^hrs 45 ^mins
62	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	320,419	90,732	3.53	6 ^hrs 48 ^mins
63	P106-090 GP106 [P106-090]	Nvidia	GP106	291,485	87,693	3.32	7 ^hrs 13 ^mins
64	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	279,907	86,421	3.24	7 ^hrs 25 ^mins
65	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	267,236	68,186	3.92	6 ^hrs 7 ^mins
66	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	260,280	84,403	3.08	7 ^hrs 47 ^mins
67	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	218,663	79,365	2.76	8 ^hrs 43 ^mins
68	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	202,709	77,412	2.62	9 ^hrs 10 ^mins
69	Radeon RX Vega M XL [Radeon RX Vega M XL]	AMD	Vega	180,449	73,769	2.45	9 ^hrs 49 ^mins
70	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	174,687	65,882	2.65	9 ^hrs 3 ^mins
71	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	151,012	70,384	2.15	11 ^hrs 11 ^mins
72	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	142,857	69,260	2.06	11 ^hrs 38 ^mins
73	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	140,027	68,746	2.04	11 ^hrs 47 ^mins
74	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	139,909	68,818	2.03	11 ^hrs 48 ^mins
75	Radeon RX 460 Baffin XT [Radeon RX 460]	AMD	Baffin XT	120,748	65,397	1.85	12 ^hrs 60 ^mins
76	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	118,554	63,641	1.86	12 ^hrs 53 ^mins
77	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	117,643	64,880	1.81	13 ^hrs 14 ^mins
78	Radeon R7 200 Series Hawaii [Radeon R7 200 Series]	AMD	Hawaii	109,300	62,785	1.74	13 ^hrs 47 ^mins
79	GTX 650 Ti Boost GK106 [GTX 650 Ti Boost]	Nvidia	GK106	101,554	58,422	1.74	13 ^hrs 48 ^mins

80	Radeon Rx 270/370 Curacao Pro [Radeon Rx 270/370]	AMD	Curacao Pro	97,611	57,295	1.70	14 ^hrs 5 ^mins
81	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	94,530	60,383	1.57	15 ^hrs 20 ^mins
82	GeForce GTX 760 GK104 [GeForce GTX 760] 2258	Nvidia	GK104	72,603	55,545	1.31	18 ^hrs 22 ^mins
83	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	60,952	52,068	1.17	20 ^hrs 30 ^mins
84	GeForce MX130 GM108M [GeForce MX130]	Nvidia	GM108M	55,262	50,111	1.10	21 ^hrs 46 ^mins
85	Radeon R7/R6 360 Series Bonaire [Radeon R7/R6 360 Series]	AMD	Bonaire	52,181	41,371	1.26	19 ^hrs 2 ^mins
86	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	33,395	39,008	0.86	28 ^hrs 2 ^mins
87	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	20,897	28,640	0.73	32 ^hrs 54 ^mins
88	Ryzen vega 8 mobile Raven [Ryzen vega 8 mobile]	AMD	Raven	14,396	25,000	0.58	41 ^hrs 41 ^mins
89	GeForce GTX 670M GF114 [GeForce GTX 670M]	Nvidia	GF114	11,853	25,000	0.47	50 ^hrs 37 ^mins
90	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	3,638	25,000	0.15	164 ^hrs 56 ^mins

Research: MYOSINS Folding Project #17434

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17434

GPU PPD Averages

Research: MYOSINS Folding Project #17434

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages