Folding project #17432, MYOSINS research

Research section Research projects and references

Project #17432 overview

Project Summary AI Beta

This project looks at how myosin proteins work in the body. Myosins are super important because they power our muscles and help move things around inside cells. Scientists want to understand them better so they can develop drugs to treat heart problems caused by faulty myosins.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 171,057
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

myosins

Proteins that produce force in cells.

Scientific: Pharmaceutical ResearchBiochemistry / Molecular Biology

Myosins are a type of protein crucial for movement within our bodies. They power muscle contractions, allowing us to walk, run, and even breathe. They also help transport materials inside our cells. Scientists study myosins because defects in these proteins can cause serious diseases like heart failure.

proteins

Large molecules essential for life.

Scientific: Pharmaceutical ResearchBiochemistry / Molecular Biology

Proteins are the building blocks of our bodies. They perform a huge variety of jobs, from transporting oxygen in our blood to fighting off infections. Scientists study proteins because understanding how they work is key to understanding health and disease.

cardiomyopathies

Diseases of the heart muscle.

Medical: HealthcareCardiology / Heart Disease

Cardiomyopathies are a group of conditions that affect the heart muscle. They can make it harder for the heart to pump blood, leading to symptoms like shortness of breath and fatigue. There are different types of cardiomyopathies, some caused by genetics and others by environmental factors.

heart failure

A condition where the heart can't pump blood effectively.

Medical: HealthcareCardiology / Heart Disease

Heart failure occurs when the heart muscle weakens and can't pump blood efficiently. This leads to a buildup of fluid in the lungs and other parts of the body. Symptoms include shortness of breath, fatigue, and swelling. There are different types of heart failure, and treatment depends on the underlying cause.

PDB

Protein Data Bank

Acronym: ResearchBiochemistry / Protein Structure

The PDB is a global database of 3D structures of biological macromolecules, mainly proteins and nucleic acids. It's a crucial resource for researchers studying protein function and design.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,031,516	198,985	30.31	0 ^hrs 48 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	4,797,825	183,240	26.18	0 ^hrs 55 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,472,454	181,074	24.70	0 ^hrs 58 ^mins
4	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,937,460	174,409	22.58	1 ^hrs 4 ^mins
5	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	3,426,443	166,438	20.59	1 ^hrs 10 ^mins
6	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,303,799	163,843	20.16	1 ^hrs 11 ^mins
7	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,272,575	164,105	19.94	1 ^hrs 12 ^mins
8	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,995,064	159,942	18.73	1 ^hrs 17 ^mins
9	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,883,686	156,517	18.42	1 ^hrs 18 ^mins
10	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,665,007	153,182	17.40	1 ^hrs 23 ^mins
11	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,442,197	146,627	16.66	1 ^hrs 26 ^mins
12	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,424,140	148,156	16.36	1 ^hrs 28 ^mins
13	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,177,330	142,668	15.26	1 ^hrs 34 ^mins
14	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,171,998	143,291	15.16	1 ^hrs 35 ^mins
15	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,003,866	138,547	14.46	1 ^hrs 40 ^mins
16	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,945,666	136,161	14.29	1 ^hrs 41 ^mins
17	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	1,897,808	130,266	14.57	1 ^hrs 39 ^mins
18	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	1,874,929	135,981	13.79	1 ^hrs 44 ^mins
19	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,636,420	130,073	12.58	1 ^hrs 54 ^mins

20	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,608,315	120,919	13.30	1 ^hrs 48 ^mins
21	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,597,320	129,215	12.36	1 ^hrs 56 ^mins
22	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,572,586	126,627	12.42	1 ^hrs 56 ^mins
23	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,223,194	117,099	10.45	2 ^hrs 18 ^mins
24	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,214,735	117,900	10.30	2 ^hrs 20 ^mins
25	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,178,346	115,443	10.21	2 ^hrs 21 ^mins
26	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	1,140,158	115,591	9.86	2 ^hrs 26 ^mins
27	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,064,830	112,032	9.50	2 ^hrs 32 ^mins
28	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,060,674	97,819	10.84	2 ^hrs 13 ^mins
29	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,008,913	107,639	9.37	2 ^hrs 34 ^mins
30	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	971,932	109,414	8.88	2 ^hrs 42 ^mins
31	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	932,718	107,443	8.68	2 ^hrs 46 ^mins
32	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	810,544	102,597	7.90	3 ^hrs 2 ^mins
33	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	807,221	101,569	7.95	3 ^hrs 1 ^mins
34	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	691,661	97,839	7.07	3 ^hrs 24 ^mins
35	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	687,422	94,992	7.24	3 ^hrs 19 ^mins
36	P104-100 GP104 [P104-100]	Nvidia	GP104	650,704	95,664	6.80	3 ^hrs 32 ^mins
37	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	592,782	92,258	6.43	3 ^hrs 44 ^mins
38	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	572,109	91,528	6.25	3 ^hrs 50 ^mins
39	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	542,385	89,730	6.04	3 ^hrs 58 ^mins

40	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	481,199	86,548	5.56	4 ^hrs 19 ^mins
41	P106-100 GP106 [P106-100]	Nvidia	GP106	454,685	84,930	5.35	4 ^hrs 29 ^mins
42	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	452,561	84,888	5.33	4 ^hrs 30 ^mins
43	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	440,999	84,298	5.23	4 ^hrs 35 ^mins
44	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	434,427	83,552	5.20	4 ^hrs 37 ^mins
45	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	400,152	80,255	4.99	4 ^hrs 49 ^mins
46	GeForce GTX 780 GK110 [GeForce GTX 780] 3977	Nvidia	GK110	362,539	75,560	4.80	5 ^hrs 0 ^mins
47	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	358,573	62,845	5.71	4 ^hrs 12 ^mins
48	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	354,310	78,190	4.53	5 ^hrs 18 ^mins
49	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	353,701	76,755	4.61	5 ^hrs 12 ^mins
50	P106-090 GP106 [P106-090]	Nvidia	GP106	280,993	72,343	3.88	6 ^hrs 11 ^mins
51	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	275,978	72,086	3.83	6 ^hrs 16 ^mins
52	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	240,800	68,632	3.51	6 ^hrs 50 ^mins
53	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	228,197	67,674	3.37	7 ^hrs 7 ^mins
54	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	213,179	65,844	3.24	7 ^hrs 25 ^mins
55	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	201,337	63,880	3.15	7 ^hrs 37 ^mins
56	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	193,270	63,863	3.03	7 ^hrs 56 ^mins
57	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	154,796	59,388	2.61	9 ^hrs 12 ^mins
58	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	148,461	58,615	2.53	9 ^hrs 29 ^mins
59	Radeon RX Vega M XL [Radeon RX Vega M XL]	AMD	Vega	146,716	53,251	2.76	8 ^hrs 43 ^mins

60	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	135,169	56,840	2.38	10 ^hrs 6 ^mins
61	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	127,907	55,745	2.29	10 ^hrs 28 ^mins
62	Radeon RX 460 Baffin XT [Radeon RX 460]	AMD	Baffin XT	109,192	52,846	2.07	11 ^hrs 37 ^mins
63	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	104,589	52,125	2.01	11 ^hrs 58 ^mins
64	Radeon R7 200 Series Hawaii [Radeon R7 200 Series]	AMD	Hawaii	99,016	51,071	1.94	12 ^hrs 23 ^mins
65	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	91,885	49,994	1.84	13 ^hrs 3 ^mins
66	Radeon R7/R6 360 Series Bonaire [Radeon R7/R6 360 Series]	AMD	Bonaire	65,819	44,870	1.47	16 ^hrs 22 ^mins
67	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	58,860	43,073	1.37	17 ^hrs 34 ^mins
68	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	51,146	40,837	1.25	19 ^hrs 10 ^mins
69	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	37,684	37,282	1.01	23 ^hrs 45 ^mins
70	GeForce 920M GK208 [GeForce 920M]	Nvidia	GK208	24,668	31,655	0.78	30 ^hrs 48 ^mins
71	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	3,120	19,100	0.16	146 ^hrs 55 ^mins

Research: MYOSINS Folding Project #17432

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17432

GPU PPD Averages

Research: MYOSINS Folding Project #17432

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages