Folding project #17424, MYOSINS research

Research section Research projects and references

Project #17424 overview

Project Summary AI Beta

This project studies myosins, proteins that power our bodies' movement. By understanding how myosins work, we hope to develop drugs for heart conditions like cardiomyopathies and heart failure.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 167,028
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

myosins

Proteins responsible for muscle contraction and cellular movement.

Technical: Biomedical ResearchBiotechnology / Cellular Biology

Myosins are a family of proteins crucial for muscle contractions and the transport of materials within cells. They convert chemical energy into mechanical force, enabling movement in organisms from microscopic levels to macroscopic actions like walking.

proteins

Large biomolecules essential for all living organisms.

Scientific: Pharmaceutical ResearchBiotechnology / Molecular Biology

Proteins are the workhorses of our cells, performing a vast array of functions. They are made up of chains of amino acids and are involved in everything from building tissues to catalyzing chemical reactions.

muscles

Tissues that contract to produce movement.

Technical: HealthcareBiotechnology / Anatomy

Muscles are tissues composed of specialized cells that can contract and relax, enabling movement. There are three types of muscles: skeletal (voluntary), smooth (involuntary), and cardiac (heart muscle).

cardiomyopathies

Diseases of the heart muscle.

Medical: HealthcareMedicine / Cardiology

Cardiomyopathies are conditions that affect the heart muscle, impairing its ability to pump blood effectively. They can be caused by genetic defects, infections, or other factors.

heart failure

A serious condition where the heart cannot pump blood efficiently.

Medical: HealthcareMedicine / Cardiology

Heart failure occurs when the heart muscle weakens and can't pump enough blood to meet the body's needs. It can lead to fatigue, shortness of breath, and fluid retention.

PDB

Protein Data Bank

Acronym: Scientific ResearchBiotechnology / Structural Biology

The Protein Data Bank (PDB) is a global repository of 3D structural data of biological macromolecules. It provides scientists with crucial information about protein shapes and functions.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,519,015	206,833	31.52	0 ^hrs 46 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,142,636	190,905	26.94	0 ^hrs 53 ^mins
3	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	4,829,778	189,927	25.43	0 ^hrs 57 ^mins
4	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,757,951	187,570	25.37	0 ^hrs 57 ^mins
5	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,158,815	179,875	23.12	1 ^hrs 2 ^mins
6	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,515,988	169,302	20.77	1 ^hrs 9 ^mins
7	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	3,397,455	167,827	20.24	1 ^hrs 11 ^mins
8	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,285,977	166,606	19.72	1 ^hrs 13 ^mins
9	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,160,442	165,191	19.13	1 ^hrs 15 ^mins
10	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,991,575	160,515	18.64	1 ^hrs 17 ^mins
11	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,765,250	156,248	17.70	1 ^hrs 21 ^mins
12	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,628,356	152,278	17.26	1 ^hrs 23 ^mins
13	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER]	Nvidia	TU104	2,616,884	154,111	16.98	1 ^hrs 25 ^mins
14	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,537,614	151,210	16.78	1 ^hrs 26 ^mins
15	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,219,765	144,408	15.37	1 ^hrs 34 ^mins
16	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,098,969	141,739	14.81	1 ^hrs 37 ^mins
17	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,045,276	141,592	14.44	1 ^hrs 40 ^mins
18	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,990,948	140,369	14.18	1 ^hrs 42 ^mins
19	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	1,984,975	140,789	14.10	1 ^hrs 42 ^mins

20	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,748,181	137,408	12.72	1 ^hrs 53 ^mins
21	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,736,791	133,977	12.96	1 ^hrs 51 ^mins
22	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,695,593	132,584	12.79	1 ^hrs 53 ^mins
23	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,678,658	132,018	12.72	1 ^hrs 53 ^mins
24	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,342,862	123,556	10.87	2 ^hrs 12 ^mins
25	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,327,735	121,793	10.90	2 ^hrs 12 ^mins
26	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,195,479	118,568	10.08	2 ^hrs 23 ^mins
27	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,176,218	115,547	10.18	2 ^hrs 21 ^mins
28	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,121,667	115,665	9.70	2 ^hrs 28 ^mins
29	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	1,112,178	115,315	9.64	2 ^hrs 29 ^mins
30	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,081,871	113,102	9.57	2 ^hrs 31 ^mins
31	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	960,356	110,402	8.70	2 ^hrs 46 ^mins
32	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	950,288	109,570	8.67	2 ^hrs 46 ^mins
33	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	922,382	107,393	8.59	2 ^hrs 48 ^mins
34	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	890,005	107,262	8.30	2 ^hrs 54 ^mins
35	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	877,894	105,242	8.34	2 ^hrs 53 ^mins
36	Quadro P5000 GP104GL [Quadro P5000]	Nvidia	GP104GL	788,482	102,940	7.66	3 ^hrs 8 ^mins
37	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	726,239	100,712	7.21	3 ^hrs 20 ^mins
38	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	705,840	96,304	7.33	3 ^hrs 16 ^mins
39	P104-100 GP104 [P104-100]	Nvidia	GP104	675,197	98,139	6.88	3 ^hrs 29 ^mins

40	GeForce GTX 780 Ti GK110 [GeForce GTX 780 Ti] 5046	Nvidia	GK110	634,016	96,387	6.58	3 ^hrs 39 ^mins
41	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	616,117	95,202	6.47	3 ^hrs 43 ^mins
42	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	604,440	93,915	6.44	3 ^hrs 44 ^mins
43	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	600,785	94,150	6.38	3 ^hrs 46 ^mins
44	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	598,498	93,802	6.38	3 ^hrs 46 ^mins
45	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	562,134	92,228	6.10	3 ^hrs 56 ^mins
46	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	530,535	89,286	5.94	4 ^hrs 2 ^mins
47	Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q]	Nvidia	TU117GLM	489,440	88,653	5.52	4 ^hrs 21 ^mins
48	P106-100 GP106 [P106-100]	Nvidia	GP106	479,572	87,701	5.47	4 ^hrs 23 ^mins
49	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	471,510	86,770	5.43	4 ^hrs 25 ^mins
50	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	465,569	86,755	5.37	4 ^hrs 28 ^mins
51	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	456,603	84,819	5.38	4 ^hrs 27 ^mins
52	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	409,617	83,515	4.90	4 ^hrs 54 ^mins
53	GeForce GTX 780 GK110 [GeForce GTX 780] 3977	Nvidia	GK110	406,093	82,266	4.94	4 ^hrs 52 ^mins
54	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	375,335	77,976	4.81	4 ^hrs 59 ^mins
55	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	364,999	79,918	4.57	5 ^hrs 15 ^mins
56	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	355,461	74,728	4.76	5 ^hrs 3 ^mins
57	P106-090 GP106 [P106-090]	Nvidia	GP106	307,035	75,557	4.06	5 ^hrs 54 ^mins
58	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	284,224	73,855	3.85	6 ^hrs 14 ^mins
59	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	243,050	69,657	3.49	6 ^hrs 53 ^mins

60	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	217,864	55,221	3.95	6 ^hrs 5 ^mins
61	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	215,934	67,496	3.20	7 ^hrs 30 ^mins
62	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	179,808	63,255	2.84	8 ^hrs 27 ^mins
63	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	157,209	60,529	2.60	9 ^hrs 14 ^mins
64	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	156,228	60,452	2.58	9 ^hrs 17 ^mins
65	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	141,147	58,447	2.41	9 ^hrs 56 ^mins
66	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	131,090	56,698	2.31	10 ^hrs 23 ^mins
67	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	115,051	54,474	2.11	11 ^hrs 22 ^mins
68	Radeon RX 460 Baffin XT [Radeon RX 460]	AMD	Baffin XT	112,064	54,035	2.07	11 ^hrs 34 ^mins
69	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	98,882	51,653	1.91	12 ^hrs 32 ^mins
70	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	97,253	50,532	1.92	12 ^hrs 28 ^mins
71	Radeon HD 7790 Bonaire XT [Radeon HD 7790]	AMD	Bonaire XT	70,346	39,289	1.79	13 ^hrs 24 ^mins
72	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	62,551	44,594	1.40	17 ^hrs 7 ^mins
73	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	61,979	44,483	1.39	17 ^hrs 14 ^mins
74	Radeon R7 250X/HD 7700/8760 R575A [Radeon R7 250X/HD 7700/8760]	AMD	R575A	50,008	41,190	1.21	19 ^hrs 46 ^mins
75	Ryzen vega 8 mobile Raven [Ryzen vega 8 mobile]	AMD	Raven	45,578	39,032	1.17	20 ^hrs 33 ^mins
76	GeForce MX250 GP108M [GeForce MX250]	Nvidia	GP108M	37,618	28,054	1.34	17 ^hrs 54 ^mins
77	GeForce 940M GM108 [GeForce 940M]	Nvidia	GM108	34,332	36,257	0.95	25 ^hrs 21 ^mins
78	GeForce GTX 550 Ti GF116 [GeForce GTX 550 Ti] 691	Nvidia	GF116	20,348	30,657	0.66	36 ^hrs 10 ^mins
79	GeForce GTS 450 GF106 [GeForce GTS 450]	Nvidia	GF106	13,952	27,030	0.52	46 ^hrs 30 ^mins

80	GeForce GT 640 GK107 [GeForce GT 640] 693	Nvidia	GK107	13,253	22,376	0.59	40 ^hrs 31 ^mins
81	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	8,938	19,500	0.46	52 ^hrs 22 ^mins
82	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	3,110	19,500	0.16	150 ^hrs 29 ^mins

Research: MYOSINS Folding Project #17424

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17424

GPU PPD Averages

Research: MYOSINS Folding Project #17424

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages