Folding project #17425, MYOSINS research

Research section Research projects and references

Project #17425 overview

Project Summary AI Beta

This project studies myosins, proteins that power muscle movement and other body functions. Scientists want to understand how drugs can fix problems with myosin that cause heart diseases like cardiomyopathy and heart failure.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 171,401
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

myosins

Proteins responsible for force generation in cells.

scientific: biotechnologybiology / cellular biology

Myosins are a class of proteins crucial for movement within cells and tissues. They power muscle contractions, transport materials within cells, and play roles in processes like cell division. Defects in myosin function can lead to various diseases, including heart conditions.

proteins

Large biomolecules essential for structure and function in living organisms.

scientific: pharmaceuticalsbiology / biochemistry

Proteins are complex molecules made up of chains of amino acids. They perform a vast array of functions in living things, including catalyzing biochemical reactions, providing structural support, transporting molecules, and defending against pathogens.

muscle

Tissue responsible for movement and contraction.

technical: medicineanatomy / physiology

Muscles are tissues composed of specialized cells that contract to generate force. This force allows us to move our bodies, maintain posture, and perform various functions like digestion and circulation.

cardiomyopathies

Diseases affecting the heart muscle.

medical: healthcarecardiology / heart disease

Cardiomyopathies are a group of conditions that weaken or stiffen the heart muscle, making it harder to pump blood effectively. This can lead to symptoms like shortness of breath, fatigue, and irregular heartbeat.

heart failure

A condition where the heart cannot pump enough blood to meet the body's needs.

medical: healthcarecardiology / congestive heart failure

Heart failure occurs when the heart muscle weakens and can't pump blood efficiently. This leads to a buildup of fluid in the lungs and other parts of the body, causing symptoms like shortness of breath, fatigue, and swelling.

PDB

Protein Data Bank

acronym: biotechnologybiology / protein structure

The Protein Data Bank (PDB) is a global repository of 3-dimensional structural data for proteins and nucleic acids. It provides a vast resource for researchers studying protein function, drug design, and other areas of biology.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,409,674	207,652	30.87	0 ^hrs 47 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,032,019	191,990	26.21	0 ^hrs 55 ^mins
3	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	4,905,524	193,041	25.41	0 ^hrs 57 ^mins
4	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,616,696	188,490	24.49	0 ^hrs 59 ^mins
5	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,042,075	180,511	22.39	1 ^hrs 4 ^mins
6	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,418,546	169,943	20.12	1 ^hrs 12 ^mins
7	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	3,348,341	169,930	19.70	1 ^hrs 13 ^mins
8	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,248,203	168,671	19.26	1 ^hrs 15 ^mins
9	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,138,176	167,260	18.76	1 ^hrs 17 ^mins
10	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,952,282	162,573	18.16	1 ^hrs 19 ^mins
11	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,658,995	157,363	16.90	1 ^hrs 25 ^mins
12	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,654,290	153,973	17.24	1 ^hrs 24 ^mins
13	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER]	Nvidia	TU104	2,612,429	156,310	16.71	1 ^hrs 26 ^mins
14	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,515,240	151,822	16.57	1 ^hrs 27 ^mins
15	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,472,246	153,500	16.11	1 ^hrs 29 ^mins
16	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,218,130	147,250	15.06	1 ^hrs 36 ^mins
17	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,034,793	143,885	14.14	1 ^hrs 42 ^mins
18	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	1,965,907	142,580	13.79	1 ^hrs 44 ^mins
19	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	1,931,670	139,640	13.83	1 ^hrs 44 ^mins

20	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,911,940	138,595	13.80	1 ^hrs 44 ^mins
21	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,728,507	135,708	12.74	1 ^hrs 53 ^mins
22	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,708,387	135,273	12.63	1 ^hrs 54 ^mins
23	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,692,880	135,044	12.54	1 ^hrs 55 ^mins
24	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,569,134	131,950	11.89	2 ^hrs 1 ^mins
25	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,300,537	123,710	10.51	2 ^hrs 17 ^mins
26	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,273,063	123,159	10.34	2 ^hrs 19 ^mins
27	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,197,118	118,617	10.09	2 ^hrs 23 ^mins
28	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,183,155	119,455	9.90	2 ^hrs 25 ^mins
29	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	1,165,559	119,567	9.75	2 ^hrs 28 ^mins
30	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,106,340	116,582	9.49	2 ^hrs 32 ^mins
31	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,100,898	116,974	9.41	2 ^hrs 33 ^mins
32	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,000,867	113,505	8.82	2 ^hrs 43 ^mins
33	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	965,210	112,139	8.61	2 ^hrs 47 ^mins
34	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	962,292	110,703	8.69	2 ^hrs 46 ^mins
35	GeForce GTX 1070 Mobile GP104M [GeForce GTX 1070 Mobile]	Nvidia	GP104M	925,950	110,385	8.39	2 ^hrs 52 ^mins
36	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	868,999	107,418	8.09	2 ^hrs 58 ^mins
37	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	863,835	107,766	8.02	2 ^hrs 60 ^mins
38	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	760,817	103,768	7.33	3 ^hrs 16 ^mins
39	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	730,709	102,503	7.13	3 ^hrs 22 ^mins

40	P104-100 GP104 [P104-100]	Nvidia	GP104	680,546	100,099	6.80	3 ^hrs 32 ^mins
41	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	621,309	96,386	6.45	3 ^hrs 43 ^mins
42	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	602,122	96,025	6.27	3 ^hrs 50 ^mins
43	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	552,525	85,867	6.43	3 ^hrs 44 ^mins
44	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	550,741	93,183	5.91	4 ^hrs 4 ^mins
45	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	518,002	85,863	6.03	3 ^hrs 59 ^mins
46	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	488,932	89,472	5.46	4 ^hrs 24 ^mins
47	P106-100 GP106 [P106-100]	Nvidia	GP106	475,018	88,756	5.35	4 ^hrs 29 ^mins
48	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	469,407	88,653	5.29	4 ^hrs 32 ^mins
49	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	465,248	88,196	5.28	4 ^hrs 33 ^mins
50	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	451,795	87,551	5.16	4 ^hrs 39 ^mins
51	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	433,421	84,345	5.14	4 ^hrs 40 ^mins
52	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	409,436	84,774	4.83	4 ^hrs 58 ^mins
53	GeForce GTX 780 GK110 [GeForce GTX 780] 3977	Nvidia	GK110	382,718	82,825	4.62	5 ^hrs 12 ^mins
54	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	351,861	79,410	4.43	5 ^hrs 25 ^mins
55	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	327,834	78,544	4.17	5 ^hrs 45 ^mins
56	P106-090 GP106 [P106-090]	Nvidia	GP106	301,505	76,231	3.96	6 ^hrs 4 ^mins
57	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	279,792	72,354	3.87	6 ^hrs 12 ^mins
58	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	279,288	74,528	3.75	6 ^hrs 24 ^mins
59	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	248,323	71,431	3.48	6 ^hrs 54 ^mins

60	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	237,331	70,498	3.37	7 ^hrs 8 ^mins
61	Quadro M2200 GM206 [Quadro M2200]	Nvidia	GM206	224,460	68,567	3.27	7 ^hrs 20 ^mins
62	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	211,704	67,576	3.13	7 ^hrs 40 ^mins
63	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	201,650	66,059	3.05	7 ^hrs 52 ^mins
64	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	196,003	66,127	2.96	8 ^hrs 6 ^mins
65	Radeon RX Vega M XL [Radeon RX Vega M XL]	AMD	Vega	170,524	62,544	2.73	8 ^hrs 48 ^mins
66	Radeon R9 200 Series Hawaii [Radeon R9 200 Series]	AMD	Hawaii	162,528	61,870	2.63	9 ^hrs 8 ^mins
67	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	155,645	61,070	2.55	9 ^hrs 25 ^mins
68	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	148,477	58,937	2.52	9 ^hrs 32 ^mins
69	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	138,748	58,996	2.35	10 ^hrs 12 ^mins
70	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	127,915	56,965	2.25	10 ^hrs 41 ^mins
71	Quadro M2000M GM107GLM [Quadro M2000M]	Nvidia	GM107GLM	118,372	56,180	2.11	11 ^hrs 23 ^mins
72	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	116,885	55,701	2.10	11 ^hrs 26 ^mins
73	GeForce GTX 775M GK104 [GeForce GTX 775M]	Nvidia	GK104	115,952	48,535	2.39	10 ^hrs 3 ^mins
74	Radeon RX 460 Baffin XT [Radeon RX 460]	AMD	Baffin XT	113,572	55,140	2.06	11 ^hrs 39 ^mins
75	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	107,196	54,029	1.98	12 ^hrs 6 ^mins
76	Radeon R7 200 Series Hawaii [Radeon R7 200 Series]	AMD	Hawaii	106,585	53,956	1.98	12 ^hrs 9 ^mins
77	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	96,866	52,267	1.85	12 ^hrs 57 ^mins
78	Quadro K4200 GK104 [Quadro K4200]	Nvidia	GK104	90,004	50,240	1.79	13 ^hrs 24 ^mins
79	Radeon R7/R6 360 Series Bonaire [Radeon R7/R6 360 Series]	AMD	Bonaire	64,875	46,479	1.40	17 ^hrs 12 ^mins

80	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	61,840	45,050	1.37	17 ^hrs 29 ^mins
81	Ryzen vega 8 mobile Raven [Ryzen vega 8 mobile]	AMD	Raven	46,646	40,939	1.14	21 ^hrs 4 ^mins
82	GeForce MX250 GP108M [GeForce MX250]	Nvidia	GP108M	41,632	29,184	1.43	16 ^hrs 49 ^mins
83	GeForce GTX 560 Ti GF114 [GeForce GTX 560 Ti]	Nvidia	GF114	39,874	38,895	1.03	23 ^hrs 25 ^mins
84	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	39,729	38,982	1.02	23 ^hrs 33 ^mins
85	Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902]	AMD	raven	35,946	36,882	0.97	24 ^hrs 37 ^mins
86	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	33,096	35,633	0.93	25 ^hrs 50 ^mins
87	GeForce GT 640 GK107 [GeForce GT 640] 693	Nvidia	GK107	27,385	34,437	0.80	30 ^hrs 11 ^mins
88	GeForce GTX 780 Ti GK110 [GeForce GTX 780 Ti] 5046	Nvidia	GK110	23,563	19,950	1.18	20 ^hrs 19 ^mins
89	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	3,202	19,950	0.16	149 ^hrs 32 ^mins

Research: MYOSINS Folding Project #17425

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17425

GPU PPD Averages

Research: MYOSINS Folding Project #17425

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages