Folding project #17420, MYOSINS research

Research section Research projects and references

Project #17420 overview

Project Summary AI Beta

This project studies myosins, proteins that power our bodies' movements. Researchers want to understand how drugs can fix problems with myosin that cause heart diseases like cardiomyopathy and heart failure.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 153,969
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

myosins

Proteins that produce force in cells

Scientific: PharmaceuticalsBiotechnology / Cellular Biology

Myosins are a family of proteins crucial for various cellular functions, primarily responsible for generating force. They power muscle contraction, intracellular transport, and other mechanical processes within cells. Defects in myosin function can lead to various diseases affecting the heart and other tissues.

proteins

Large biomolecules essential for life

Scientific: PharmaceuticalsBiotechnology / Molecular Biology

Proteins are complex molecules that perform a wide range of functions in living organisms. They act as enzymes, structural components, hormones, and antibodies, among other roles. Their diverse structures and properties allow them to carry out the complex processes necessary for life.

hypertrophic cardiomyopathy

A disease causing the heart muscle to thicken

Medical: HealthcareMedicine / Cardiology

Hypertrophic cardiomyopathy (HCM) is a genetic heart condition where the heart muscle becomes abnormally thick. This thickening can make it harder for the heart to pump blood effectively, leading to symptoms like shortness of breath, chest pain, and fainting.

dilated cardiomyopathy

A disease causing the heart chambers to enlarge

Medical: HealthcareMedicine / Cardiology

Dilated cardiomyopathy (DCM) is a heart condition where the heart's chambers become enlarged and weakened. This makes it difficult for the heart to pump blood effectively, leading to symptoms like fatigue, shortness of breath, and swelling in the legs and feet.

heart failure

A condition where the heart can't pump blood efficiently

Medical: HealthcareMedicine / Cardiology

Heart failure occurs when the heart muscle cannot pump blood effectively to meet the body's needs. This can lead to fluid buildup in the lungs and other parts of the body, causing symptoms like shortness of breath, fatigue, and swelling.

PDB

Protein Data Bank

Acronym: ResearchBiotechnology / Structural Biology

The Protein Data Bank (PDB) is a global repository for 3D structural data of biological macromolecules, primarily proteins and nucleic acids. Researchers use this information to understand protein function, design drugs, and develop new technologies.

Molecule of the Month

A monthly feature highlighting a protein structure in the PDB

Acronym: ResearchBiotechnology / Structural Biology

The 'Molecule of the Month' is a recurring feature on the Protein Data Bank (PDB) website. Each month, a specific protein structure with unique features or scientific significance is highlighted, providing researchers and the public with insights into its biological function and importance.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,728,389	198,192	33.95	0 ^hrs 42 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,179,058	180,616	28.67	0 ^hrs 50 ^mins
3	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	4,919,069	180,239	27.29	0 ^hrs 53 ^mins
4	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,771,352	177,311	26.91	0 ^hrs 54 ^mins
5	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,198,154	170,002	24.69	0 ^hrs 58 ^mins
6	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,409,158	158,110	21.56	1 ^hrs 7 ^mins
7	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,286,413	158,175	20.78	1 ^hrs 9 ^mins
8	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,100,418	154,303	20.09	1 ^hrs 12 ^mins
9	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,073,952	153,157	20.07	1 ^hrs 12 ^mins
10	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	3,015,396	153,191	19.68	1 ^hrs 13 ^mins
11	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,952,270	151,591	19.48	1 ^hrs 14 ^mins
12	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,894,457	150,748	19.20	1 ^hrs 15 ^mins
13	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,735,795	147,385	18.56	1 ^hrs 18 ^mins
14	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER]	Nvidia	TU104	2,731,034	148,119	18.44	1 ^hrs 18 ^mins
15	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,320,436	140,238	16.55	1 ^hrs 27 ^mins
16	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,079,248	135,347	15.36	1 ^hrs 34 ^mins
17	GeForce RTX 2080 SUPER Mobile / Max-Q TU104M [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104M	2,037,275	135,180	15.07	1 ^hrs 36 ^mins
18	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,926,187	131,752	14.62	1 ^hrs 38 ^mins
19	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	1,844,481	128,484	14.36	1 ^hrs 40 ^mins

20	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,834,142	129,553	14.16	1 ^hrs 42 ^mins
21	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,797,598	127,303	14.12	1 ^hrs 42 ^mins
22	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,785,458	127,917	13.96	1 ^hrs 43 ^mins
23	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,566,004	122,947	12.74	1 ^hrs 53 ^mins
24	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,449,285	119,574	12.12	1 ^hrs 59 ^mins
25	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,371,451	117,994	11.62	2 ^hrs 4 ^mins
26	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,202,185	112,544	10.68	2 ^hrs 15 ^mins
27	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,194,624	112,458	10.62	2 ^hrs 16 ^mins
28	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,162,297	111,452	10.43	2 ^hrs 18 ^mins
29	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,050,167	106,166	9.89	2 ^hrs 26 ^mins
30	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,031,691	107,069	9.64	2 ^hrs 29 ^mins
31	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	982,652	104,911	9.37	2 ^hrs 34 ^mins
32	Quadro P5000 GP104GL [Quadro P5000]	Nvidia	GP104GL	950,962	103,656	9.17	2 ^hrs 37 ^mins
33	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	912,913	102,717	8.89	2 ^hrs 42 ^mins
34	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	876,020	99,696	8.79	2 ^hrs 44 ^mins
35	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	857,869	100,812	8.51	2 ^hrs 49 ^mins
36	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	800,363	98,252	8.15	2 ^hrs 57 ^mins
37	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	752,005	91,756	8.20	2 ^hrs 56 ^mins
38	P104-100 GP104 [P104-100]	Nvidia	GP104	688,138	93,651	7.35	3 ^hrs 16 ^mins
39	GeForce GTX 780 Ti GK110 [GeForce GTX 780 Ti] 5046	Nvidia	GK110	648,056	92,027	7.04	3 ^hrs 24 ^mins

40	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	645,988	91,842	7.03	3 ^hrs 25 ^mins
41	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	607,713	89,725	6.77	3 ^hrs 33 ^mins
42	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	607,045	90,247	6.73	3 ^hrs 34 ^mins
43	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	588,432	89,342	6.59	3 ^hrs 39 ^mins
44	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	570,532	88,081	6.48	3 ^hrs 42 ^mins
45	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	495,620	84,358	5.88	4 ^hrs 5 ^mins
46	P106-100 GP106 [P106-100]	Nvidia	GP106	486,143	83,321	5.83	4 ^hrs 7 ^mins
47	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	467,820	80,586	5.81	4 ^hrs 8 ^mins
48	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	465,199	82,376	5.65	4 ^hrs 15 ^mins
49	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	419,966	77,471	5.42	4 ^hrs 26 ^mins
50	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	411,495	78,898	5.22	4 ^hrs 36 ^mins
51	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	385,876	77,615	4.97	4 ^hrs 50 ^mins
52	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	365,694	75,861	4.82	4 ^hrs 59 ^mins
53	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	363,436	72,995	4.98	4 ^hrs 49 ^mins
54	P106-090 GP106 [P106-090]	Nvidia	GP106	332,185	73,540	4.52	5 ^hrs 19 ^mins
55	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	304,754	71,590	4.26	5 ^hrs 38 ^mins
56	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	300,539	71,335	4.21	5 ^hrs 42 ^mins
57	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	261,946	67,948	3.86	6 ^hrs 14 ^mins
58	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	246,958	66,709	3.70	6 ^hrs 29 ^mins
59	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	237,953	63,490	3.75	6 ^hrs 24 ^mins

60	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	222,019	64,196	3.46	6 ^hrs 56 ^mins
61	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	200,825	62,256	3.23	7 ^hrs 26 ^mins
62	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	171,137	58,641	2.92	8 ^hrs 13 ^mins
63	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	152,836	56,810	2.69	8 ^hrs 55 ^mins
64	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	145,791	55,988	2.60	9 ^hrs 13 ^mins
65	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	132,979	54,255	2.45	9 ^hrs 48 ^mins
66	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	126,402	51,748	2.44	9 ^hrs 50 ^mins
67	GeForce GTX 670MX GK106 [GeForce GTX 670MX]	Nvidia	GK106	118,916	50,977	2.33	10 ^hrs 17 ^mins
68	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	105,092	50,329	2.09	11 ^hrs 30 ^mins
69	GeForce GTX 770 GK104 [GeForce GTX 770] 3213	Nvidia	GK104	101,861	49,751	2.05	11 ^hrs 43 ^mins
70	Quadro K4200 GK104 [Quadro K4200]	Nvidia	GK104	99,504	49,231	2.02	11 ^hrs 52 ^mins
71	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	99,444	49,310	2.02	11 ^hrs 54 ^mins
72	Polaris11 Baffin [Polaris11]	AMD	Baffin	92,265	47,716	1.93	12 ^hrs 25 ^mins
73	Radeon HD 7790 Bonaire XT [Radeon HD 7790]	AMD	Bonaire XT	76,114	36,223	2.10	11 ^hrs 25 ^mins
74	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	65,496	43,003	1.52	15 ^hrs 45 ^mins
75	Radeon R7 250X/HD 7700/8760 R575A [Radeon R7 250X/HD 7700/8760]	AMD	R575A	50,133	38,094	1.32	18 ^hrs 14 ^mins
76	Ryzen vega 8 mobile Raven [Ryzen vega 8 mobile]	AMD	Raven	46,974	38,370	1.22	19 ^hrs 36 ^mins
77	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	37,297	35,285	1.06	22 ^hrs 42 ^mins
78	GeForce GTX 550 Ti GF116 [GeForce GTX 550 Ti] 691	Nvidia	GF116	21,662	29,716	0.73	32 ^hrs 55 ^mins
79	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	16,746	21,388	0.78	30 ^hrs 39 ^mins

80	GeForce GTS 450 GF106 [GeForce GTS 450]	Nvidia	GF106	11,779	20,929	0.56	42 ^hrs 39 ^mins
81	Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902]	AMD	raven	6,383	18,000	0.35	67 ^hrs 41 ^mins
82	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	3,102	18,000	0.17	139 ^hrs 16 ^mins

Research: MYOSINS Folding Project #17420

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17420

GPU PPD Averages

Research: MYOSINS Folding Project #17420

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages