Folding project #17421, MYOSINS research

Research section Research projects and references

Project #17421 overview

Project Summary AI Beta

This project looks at myosins, proteins that power movement in our bodies. Myosins are involved in muscle contractions and moving things inside cells. Researchers want to understand how drugs could fix problems with myosin that cause heart conditions like cardiomyopathy and heart failure.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 153,976
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Myosin

A type of protein that converts chemical energy into mechanical work.

Scientific: PharmaceuticalBiotechnology / Cellular Biology

Myosins are essential proteins found in all eukaryotic cells. They are responsible for a wide range of functions, including muscle contraction, cell movement, and intracellular transport. Myosins function by binding to actin filaments and using ATP to move along them, generating force and enabling various cellular processes.

Cardiomyopathy

A disease of the heart muscle that makes it harder for the heart to pump blood.

Medical: HealthcareMedicine / Cardiology

Cardiomyopathy is a group of diseases that affect the heart muscle, making it difficult for the heart to pump blood effectively. This can lead to symptoms such as shortness of breath, fatigue, and chest pain. There are different types of cardiomyopathy, including hypertrophic cardiomyopathy, dilated cardiomyopathy, and restrictive cardiomyopathy.

Heart Failure

A condition in which the heart can't pump blood effectively enough to meet the body's needs.

Medical: HealthcareMedicine / Cardiology

Heart failure is a serious condition that occurs when the heart muscle weakens and cannot pump blood as efficiently as it should. This can lead to fluid buildup in the lungs, legs, and other parts of the body. Symptoms include shortness of breath, fatigue, swelling, and rapid heartbeat.

PDB

Protein Data Bank

Acronym: ResearchBiotechnology / Structural Biology

The Protein Data Bank (PDB) is a global repository of 3D structural data for large biological molecules. This information is crucial for understanding protein function and developing new drugs and therapies.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,430,669	192,886	33.34	0 ^hrs 43 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,118,463	179,937	28.45	0 ^hrs 51 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,740,793	176,666	26.83	0 ^hrs 54 ^mins
4	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	4,735,241	177,958	26.61	0 ^hrs 54 ^mins
5	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,082,522	167,396	24.39	0 ^hrs 59 ^mins
6	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,471,860	159,892	21.71	1 ^hrs 6 ^mins
7	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,299,341	157,933	20.89	1 ^hrs 9 ^mins
8	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,076,027	153,933	19.98	1 ^hrs 12 ^mins
9	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,874,153	149,090	19.28	1 ^hrs 15 ^mins
10	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER]	Nvidia	TU104	2,699,082	147,593	18.29	1 ^hrs 19 ^mins
11	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,697,190	145,402	18.55	1 ^hrs 18 ^mins
12	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,606,238	144,494	18.04	1 ^hrs 20 ^mins
13	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,492,631	142,787	17.46	1 ^hrs 22 ^mins
14	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,382,167	141,063	16.89	1 ^hrs 25 ^mins
15	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,354,223	140,973	16.70	1 ^hrs 26 ^mins
16	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,079,990	134,890	15.42	1 ^hrs 33 ^mins
17	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,984,906	132,016	15.04	1 ^hrs 36 ^mins
18	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,853,136	129,148	14.35	1 ^hrs 40 ^mins
19	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,811,028	128,526	14.09	1 ^hrs 42 ^mins

20	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,805,169	128,363	14.06	1 ^hrs 42 ^mins
21	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,535,706	122,269	12.56	1 ^hrs 55 ^mins
22	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,405,644	117,495	11.96	2 ^hrs 0 ^mins
23	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,364,039	117,864	11.57	2 ^hrs 4 ^mins
24	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,219,705	112,535	10.84	2 ^hrs 13 ^mins
25	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,186,418	111,626	10.63	2 ^hrs 15 ^mins
26	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,148,242	110,960	10.35	2 ^hrs 19 ^mins
27	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,076,972	108,903	9.89	2 ^hrs 26 ^mins
28	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	989,913	104,576	9.47	2 ^hrs 32 ^mins
29	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	946,312	102,534	9.23	2 ^hrs 36 ^mins
30	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	931,109	103,478	9.00	2 ^hrs 40 ^mins
31	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	902,432	101,598	8.88	2 ^hrs 42 ^mins
32	Quadro P5000 GP104GL [Quadro P5000]	Nvidia	GP104GL	880,950	94,616	9.31	2 ^hrs 35 ^mins
33	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	856,850	98,017	8.74	2 ^hrs 45 ^mins
34	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	838,991	100,076	8.38	2 ^hrs 52 ^mins
35	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	748,975	96,223	7.78	3 ^hrs 5 ^mins
36	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	695,788	88,540	7.86	3 ^hrs 3 ^mins
37	P104-100 GP104 [P104-100]	Nvidia	GP104	682,317	93,470	7.30	3 ^hrs 17 ^mins
38	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	660,289	92,502	7.14	3 ^hrs 22 ^mins
39	GeForce GTX 780 Ti GK110 [GeForce GTX 780 Ti] 5046	Nvidia	GK110	652,848	92,304	7.07	3 ^hrs 24 ^mins

40	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	617,248	90,418	6.83	3 ^hrs 31 ^mins
41	GeForce GTX 780 GK110 [GeForce GTX 780] 3977	Nvidia	GK110	587,237	89,129	6.59	3 ^hrs 39 ^mins
42	P106-100 GP106 [P106-100]	Nvidia	GP106	489,307	83,000	5.90	4 ^hrs 4 ^mins
43	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	486,753	83,495	5.83	4 ^hrs 7 ^mins
44	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	471,888	79,929	5.90	4 ^hrs 4 ^mins
45	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	443,370	80,847	5.48	4 ^hrs 23 ^mins
46	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	435,141	79,012	5.51	4 ^hrs 21 ^mins
47	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	391,814	75,170	5.21	4 ^hrs 36 ^mins
48	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	377,566	76,410	4.94	4 ^hrs 51 ^mins
49	P106-090 GP106 [P106-090]	Nvidia	GP106	328,760	73,269	4.49	5 ^hrs 21 ^mins
50	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	319,724	72,931	4.38	5 ^hrs 28 ^mins
51	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	297,843	70,661	4.22	5 ^hrs 42 ^mins
52	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	247,273	66,731	3.71	6 ^hrs 29 ^mins
53	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	217,704	64,000	3.40	7 ^hrs 3 ^mins
54	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	200,763	62,117	3.23	7 ^hrs 26 ^mins
55	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	171,336	58,983	2.90	8 ^hrs 16 ^mins
56	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	152,383	56,705	2.69	8 ^hrs 56 ^mins
57	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	139,807	55,300	2.53	9 ^hrs 30 ^mins
58	GRID M40 GM107GL [GRID M40]	Nvidia	GM107GL	135,351	53,944	2.51	9 ^hrs 34 ^mins
59	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	131,706	54,074	2.44	9 ^hrs 51 ^mins

60	Radeon RX 460 Baffin XT [Radeon RX 460]	AMD	Baffin XT	128,326	53,644	2.39	10 ^hrs 2 ^mins
61	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	117,116	51,977	2.25	10 ^hrs 39 ^mins
62	Quadro K4200 GK104 [Quadro K4200]	Nvidia	GK104	100,445	48,381	2.08	11 ^hrs 34 ^mins
63	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	100,426	45,192	2.22	10 ^hrs 48 ^mins
64	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	96,429	48,861	1.97	12 ^hrs 10 ^mins
65	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	61,933	42,048	1.47	16 ^hrs 18 ^mins
66	Radeon R7 250X/HD 7700/8760 R575A [Radeon R7 250X/HD 7700/8760]	AMD	R575A	53,052	39,907	1.33	18 ^hrs 3 ^mins
67	Ryzen vega 8 mobile Raven [Ryzen vega 8 mobile]	AMD	Raven	46,767	38,265	1.22	19 ^hrs 38 ^mins
68	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	35,467	36,204	0.98	24 ^hrs 30 ^mins
69	GeForce GT 730 GK208B [GeForce GT 730] 692.7	Nvidia	GK208B	33,402	34,291	0.97	24 ^hrs 38 ^mins
70	GeForce 920M GK208 [GeForce 920M]	Nvidia	GK208	30,559	33,345	0.92	26 ^hrs 11 ^mins
71	Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902]	AMD	raven	23,033	23,910	0.96	24 ^hrs 55 ^mins
72	GeForce GTX 550 Ti GF116 [GeForce GTX 550 Ti] 691	Nvidia	GF116	21,491	29,598	0.73	33 ^hrs 3 ^mins

Research: MYOSINS Folding Project #17421

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17421

GPU PPD Averages

Research: MYOSINS Folding Project #17421

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages