Folding project #17427, MYOSINS research

Research section Research projects and references

Project #17427 overview

Project Summary AI Beta

This project studies myosins, the proteins that power our bodies' movements. Scientists want to understand how drugs could fix problems with myosin that cause heart diseases like cardiomyopathy and heart failure.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 171,418
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

myosin

Protein responsible for force generation in cells and muscles.

scientific: biotechnologybiology / molecular biology

Myosins are a family of proteins crucial for movement within our bodies. They power muscle contractions, allowing us to walk, talk, and perform other actions. Myosins also transport materials inside cells, essential for various biological processes. Defects in myosin can lead to diseases affecting heart function (cardiomyopathies) and overall cellular activity.

proteins

Large biomolecules essential for various cellular functions.

scientific: biotechnologybiology / molecular biology

Proteins are the workhorses of our bodies. They perform a wide range of tasks, from building and repairing tissues to catalyzing chemical reactions. Their diverse structures and functions are fundamental to life.

muscle

Tissue responsible for movement and force generation.

scientific: medicinebiology / anatomy

Muscles are tissues composed of cells that can contract, generating the force needed for movement. There are three main types of muscle: skeletal (for voluntary movement), smooth (found in internal organs), and cardiac (specific to the heart).

cardiomyopathy

Disease affecting the heart muscle.

medical: healthcaremedicine / cardiology

Cardiomyopathy refers to a group of diseases that weaken the heart muscle, making it difficult for the heart to pump blood effectively. This can lead to fatigue, shortness of breath, and other symptoms. There are various types of cardiomyopathy, each with different causes and characteristics.

heart failure

Condition where the heart cannot pump enough blood to meet the body's needs.

medical: healthcaremedicine / cardiology

Heart failure occurs when the heart muscle weakens and can't effectively pump blood throughout the body. This leads to symptoms like fatigue, shortness of breath, and swelling in the legs and ankles. Heart failure is a serious condition that requires medical treatment.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,594,261	213,466	30.89	0 ^hrs 47 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,269,030	198,380	26.56	0 ^hrs 54 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,688,028	191,523	24.48	0 ^hrs 59 ^mins
4	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,151,907	184,738	22.47	1 ^hrs 4 ^mins
5	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	3,552,535	175,154	20.28	1 ^hrs 11 ^mins
6	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,485,143	173,260	20.12	1 ^hrs 12 ^mins
7	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,287,875	170,608	19.27	1 ^hrs 15 ^mins
8	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,163,874	169,596	18.66	1 ^hrs 17 ^mins
9	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,010,106	165,786	18.16	1 ^hrs 19 ^mins
10	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,631,393	157,180	16.74	1 ^hrs 26 ^mins
11	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER]	Nvidia	TU104	2,591,145	157,831	16.42	1 ^hrs 28 ^mins
12	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,581,742	156,352	16.51	1 ^hrs 27 ^mins
13	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,562,218	153,324	16.71	1 ^hrs 26 ^mins
14	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,272,799	150,304	15.12	1 ^hrs 35 ^mins
15	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,079,857	146,249	14.22	1 ^hrs 41 ^mins
16	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,017,580	144,420	13.97	1 ^hrs 43 ^mins
17	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	1,997,768	144,888	13.79	1 ^hrs 44 ^mins
18	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,962,222	142,927	13.73	1 ^hrs 45 ^mins
19	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,732,690	137,703	12.58	1 ^hrs 54 ^mins

20	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,724,672	137,372	12.55	1 ^hrs 55 ^mins
21	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,717,620	136,286	12.60	1 ^hrs 54 ^mins
22	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	1,305,455	125,595	10.39	2 ^hrs 19 ^mins
23	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,303,707	126,219	10.33	2 ^hrs 19 ^mins
24	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,285,811	125,005	10.29	2 ^hrs 20 ^mins
25	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,242,528	118,947	10.45	2 ^hrs 18 ^mins
26	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,199,177	121,975	9.83	2 ^hrs 26 ^mins
27	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,123,375	119,305	9.42	2 ^hrs 33 ^mins
28	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,106,975	119,218	9.29	2 ^hrs 35 ^mins
29	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,072,288	116,231	9.23	2 ^hrs 36 ^mins
30	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	1,008,616	115,168	8.76	2 ^hrs 44 ^mins
31	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	955,043	112,628	8.48	2 ^hrs 50 ^mins
32	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	951,419	112,496	8.46	2 ^hrs 50 ^mins
33	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	950,622	111,640	8.52	2 ^hrs 49 ^mins
34	GeForce GTX 1070 Mobile GP104M [GeForce GTX 1070 Mobile]	Nvidia	GP104M	944,799	113,019	8.36	2 ^hrs 52 ^mins
35	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	909,579	110,708	8.22	2 ^hrs 55 ^mins
36	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	758,056	105,036	7.22	3 ^hrs 20 ^mins
37	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	741,545	102,552	7.23	3 ^hrs 19 ^mins
38	P104-100 GP104 [P104-100]	Nvidia	GP104	688,158	101,572	6.78	3 ^hrs 33 ^mins
39	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	637,314	98,804	6.45	3 ^hrs 43 ^mins

40	GeForce GTX 780 Ti GK110 [GeForce GTX 780 Ti] 5046	Nvidia	GK110	637,120	99,232	6.42	3 ^hrs 44 ^mins
41	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	614,493	97,943	6.27	3 ^hrs 50 ^mins
42	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	604,529	97,384	6.21	3 ^hrs 52 ^mins
43	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	563,369	94,961	5.93	4 ^hrs 3 ^mins
44	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	551,190	93,012	5.93	4 ^hrs 3 ^mins
45	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	487,728	90,446	5.39	4 ^hrs 27 ^mins
46	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	483,034	90,624	5.33	4 ^hrs 30 ^mins
47	P106-100 GP106 [P106-100]	Nvidia	GP106	482,524	90,230	5.35	4 ^hrs 29 ^mins
48	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	469,638	88,839	5.29	4 ^hrs 32 ^mins
49	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	382,646	82,288	4.65	5 ^hrs 10 ^mins
50	GeForce GTX 780 GK110 [GeForce GTX 780] 3977	Nvidia	GK110	381,896	83,395	4.58	5 ^hrs 14 ^mins
51	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	361,615	81,232	4.45	5 ^hrs 23 ^mins
52	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	360,505	70,806	5.09	4 ^hrs 43 ^mins
53	P106-090 GP106 [P106-090]	Nvidia	GP106	303,547	77,272	3.93	6 ^hrs 7 ^mins
54	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	296,564	77,091	3.85	6 ^hrs 14 ^mins
55	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	286,249	72,275	3.96	6 ^hrs 4 ^mins
56	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	283,503	75,725	3.74	6 ^hrs 25 ^mins
57	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	248,606	72,097	3.45	6 ^hrs 58 ^mins
58	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	241,545	71,747	3.37	7 ^hrs 8 ^mins
59	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	175,865	64,376	2.73	8 ^hrs 47 ^mins

60	Radeon RX Vega M XL [Radeon RX Vega M XL]	AMD	Vega	171,788	62,366	2.75	8 ^hrs 43 ^mins
61	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	169,529	59,542	2.85	8 ^hrs 26 ^mins
62	Radeon R9 200 Series Hawaii [Radeon R9 200 Series]	AMD	Hawaii	169,098	63,715	2.65	9 ^hrs 3 ^mins
63	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	161,774	62,631	2.58	9 ^hrs 17 ^mins
64	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	153,958	61,802	2.49	9 ^hrs 38 ^mins
65	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	142,726	60,267	2.37	10 ^hrs 8 ^mins
66	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	133,202	58,836	2.26	10 ^hrs 36 ^mins
67	Radeon RX 460 Baffin XT [Radeon RX 460]	AMD	Baffin XT	125,165	57,444	2.18	11 ^hrs 1 ^mins
68	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	113,322	55,790	2.03	11 ^hrs 49 ^mins
69	Radeon R7 200 Series Hawaii [Radeon R7 200 Series]	AMD	Hawaii	109,412	55,077	1.99	12 ^hrs 5 ^mins
70	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	98,821	53,253	1.86	12 ^hrs 56 ^mins
71	Quadro K4200 GK104 [Quadro K4200]	Nvidia	GK104	95,618	52,279	1.83	13 ^hrs 7 ^mins
72	Radeon RX 550 Series AMD/ATI [Radeon RX 550 Series]	AMD	AMD/ATI	82,811	50,127	1.65	14 ^hrs 32 ^mins
73	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	67,079	35,780	1.87	12 ^hrs 48 ^mins
74	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	62,670	45,776	1.37	17 ^hrs 32 ^mins
75	Radeon R7 250X/HD 7700/8760 R575A [Radeon R7 250X/HD 7700/8760]	AMD	R575A	54,814	43,616	1.26	19 ^hrs 6 ^mins
76	Ryzen vega 8 mobile Raven [Ryzen vega 8 mobile]	AMD	Raven	45,498	41,057	1.11	21 ^hrs 39 ^mins
77	GeForce GTX 560 Ti GF114 [GeForce GTX 560 Ti]	Nvidia	GF114	40,694	39,742	1.02	23 ^hrs 26 ^mins
78	Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902]	AMD	raven	37,378	38,259	0.98	24 ^hrs 34 ^mins
79	GeForce GT 730 GK208B [GeForce GT 730] 692.7	Nvidia	GK208B	32,319	36,717	0.88	27 ^hrs 16 ^mins

80	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	31,217	31,766	0.98	24 ^hrs 25 ^mins
81	GeForce GT 640 GK107 [GeForce GT 640] 693	Nvidia	GK107	24,495	30,932	0.79	30 ^hrs 18 ^mins
82	GeForce MX250 GP108M [GeForce MX250]	Nvidia	GP108M	21,876	21,951	1.00	24 ^hrs 5 ^mins
83	GeForce GTX 550 Ti GF116 [GeForce GTX 550 Ti] 691	Nvidia	GF116	19,136	30,886	0.62	38 ^hrs 44 ^mins
84	FirePro W2100 Oland GL [FirePro W2100]	AMD	Oland GL	12,858	29,433	0.44	54 ^hrs 56 ^mins
85	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	3,650	20,300	0.18	133 ^hrs 29 ^mins
86	GeForce GT 630M GF108 [GeForce GT 630M]	Nvidia	GF108	3,305	20,300	0.16	147 ^hrs 25 ^mins

Research: MYOSINS Folding Project #17427

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17427

GPU PPD Averages

Research: MYOSINS Folding Project #17427

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages