Folding project #17426, MYOSINS research

Research section Research projects and references

Project #17426 overview

Project Summary AI Beta

This project looks at myosin proteins, which are super important for how our bodies move! They're involved in everything from muscles contracting to things moving inside our cells. Scientists want to understand how drugs could help fix problems with myosin that cause heart diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 171,306
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Myosins

Motor proteins that convert chemical energy into mechanical work.

Scientific: PharmaceuticalBiotechnology / Cellular Biology

Myosins are a family of proteins crucial for movement within cells and throughout the body. They act like tiny motors, using energy from ATP to pull on filaments, enabling muscle contraction, cell division, and intracellular transport. Defects in myosin function can lead to various diseases, including cardiomyopathies and heart failure.

Cardiomyopathies

Diseases of the heart muscle that affect its ability to pump blood effectively.

Medical: HealthcareMedicine / Cardiology

Cardiomyopathies are a group of conditions that weaken and enlarge the heart muscle, impairing its ability to pump blood properly. This can lead to fatigue, shortness of breath, fluid retention, and even heart failure. Types include hypertrophic cardiomyopathy (thickened heart muscle), dilated cardiomyopathy (enlarged heart chambers), and restrictive cardiomyopathy (stiff heart muscle). Treatments vary depending on the type and severity.

Heart Failure

A chronic condition where the heart can't pump blood effectively enough to meet the body's needs.

Medical: HealthcareMedicine / Cardiology

Heart failure occurs when the heart muscle weakens and struggles to pump sufficient blood to the rest of the body. This can lead to fluid buildup in the lungs and legs, fatigue, shortness of breath, and other symptoms. It often results from underlying conditions like coronary artery disease, high blood pressure, or cardiomyopathies. Treatment focuses on managing symptoms, slowing disease progression, and improving quality of life.

PDB

Protein Data Bank

Acronym: Scientific ResearchBiotechnology / Structural Biology

The PDB is a global repository of 3D structural data for biological macromolecules, primarily proteins and nucleic acids. This information is crucial for understanding how these molecules function and for designing new drugs and therapies.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,566,305	212,582	30.89	0 ^hrs 47 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,141,081	194,388	26.45	0 ^hrs 54 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,750,109	192,424	24.69	0 ^hrs 58 ^mins
4	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,204,790	185,295	22.69	1 ^hrs 3 ^mins
5	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,492,670	172,972	20.19	1 ^hrs 11 ^mins
6	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	3,469,800	173,510	20.00	1 ^hrs 12 ^mins
7	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,178,707	164,074	19.37	1 ^hrs 14 ^mins
8	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,164,166	169,015	18.72	1 ^hrs 17 ^mins
9	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,030,556	166,052	18.25	1 ^hrs 19 ^mins
10	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,785,865	160,115	17.40	1 ^hrs 23 ^mins
11	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,627,572	157,354	16.70	1 ^hrs 26 ^mins
12	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER]	Nvidia	TU104	2,603,398	157,884	16.49	1 ^hrs 27 ^mins
13	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,485,956	151,211	16.44	1 ^hrs 28 ^mins
14	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,297,442	151,567	15.16	1 ^hrs 35 ^mins
15	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,204,057	147,722	14.92	1 ^hrs 37 ^mins
16	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,077,653	146,446	14.19	1 ^hrs 42 ^mins
17	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,963,575	141,694	13.86	1 ^hrs 44 ^mins
18	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	1,836,563	132,526	13.86	1 ^hrs 44 ^mins
19	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,767,681	138,944	12.72	1 ^hrs 53 ^mins

20	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,754,768	138,422	12.68	1 ^hrs 54 ^mins
21	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,735,605	136,877	12.68	1 ^hrs 54 ^mins
22	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,520,946	132,233	11.50	2 ^hrs 5 ^mins
23	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	1,354,449	126,980	10.67	2 ^hrs 15 ^mins
24	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,328,889	126,459	10.51	2 ^hrs 17 ^mins
25	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,281,456	122,089	10.50	2 ^hrs 17 ^mins
26	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,258,842	122,310	10.29	2 ^hrs 20 ^mins
27	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	1,212,049	122,698	9.88	2 ^hrs 26 ^mins
28	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,200,060	121,956	9.84	2 ^hrs 26 ^mins
29	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,137,493	119,585	9.51	2 ^hrs 31 ^mins
30	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,123,253	119,038	9.44	2 ^hrs 33 ^mins
31	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	949,206	112,330	8.45	2 ^hrs 50 ^mins
32	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	941,271	111,923	8.41	2 ^hrs 51 ^mins
33	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	938,414	111,537	8.41	2 ^hrs 51 ^mins
34	GeForce GTX 1070 Mobile GP104M [GeForce GTX 1070 Mobile]	Nvidia	GP104M	928,526	112,617	8.24	2 ^hrs 55 ^mins
35	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	904,051	108,364	8.34	2 ^hrs 53 ^mins
36	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	754,005	104,833	7.19	3 ^hrs 20 ^mins
37	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	752,829	103,752	7.26	3 ^hrs 18 ^mins
38	P104-100 GP104 [P104-100]	Nvidia	GP104	692,146	101,743	6.80	3 ^hrs 32 ^mins
39	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	613,603	97,631	6.28	3 ^hrs 49 ^mins

40	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	613,473	97,868	6.27	3 ^hrs 50 ^mins
41	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	586,772	95,537	6.14	3 ^hrs 54 ^mins
42	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	574,099	95,402	6.02	3 ^hrs 59 ^mins
43	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	486,352	89,891	5.41	4 ^hrs 26 ^mins
44	P106-100 GP106 [P106-100]	Nvidia	GP106	482,595	90,251	5.35	4 ^hrs 29 ^mins
45	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	478,727	90,299	5.30	4 ^hrs 32 ^mins
46	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	449,035	88,217	5.09	4 ^hrs 43 ^mins
47	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	433,559	86,141	5.03	4 ^hrs 46 ^mins
48	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	427,098	83,493	5.12	4 ^hrs 42 ^mins
49	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	412,749	83,976	4.92	4 ^hrs 53 ^mins
50	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	410,386	85,911	4.78	5 ^hrs 1 ^mins
51	GeForce GTX 780 GK110 [GeForce GTX 780] 3977	Nvidia	GK110	381,024	83,520	4.56	5 ^hrs 16 ^mins
52	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	375,813	82,999	4.53	5 ^hrs 18 ^mins
53	P106-090 GP106 [P106-090]	Nvidia	GP106	305,113	77,444	3.94	6 ^hrs 6 ^mins
54	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	288,018	75,377	3.82	6 ^hrs 17 ^mins
55	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	280,503	74,893	3.75	6 ^hrs 24 ^mins
56	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	248,723	72,180	3.45	6 ^hrs 58 ^mins
57	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	241,490	71,729	3.37	7 ^hrs 8 ^mins
58	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	220,351	69,202	3.18	7 ^hrs 32 ^mins
59	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	214,727	69,050	3.11	7 ^hrs 43 ^mins

60	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	197,511	66,670	2.96	8 ^hrs 6 ^mins
61	Radeon RX Vega M XL [Radeon RX Vega M XL]	AMD	Vega	181,060	65,204	2.78	8 ^hrs 39 ^mins
62	Radeon R9 200 Series Hawaii [Radeon R9 200 Series]	AMD	Hawaii	168,757	63,589	2.65	9 ^hrs 3 ^mins
63	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	162,025	62,645	2.59	9 ^hrs 17 ^mins
64	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	152,119	61,550	2.47	9 ^hrs 43 ^mins
65	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	138,375	59,633	2.32	10 ^hrs 21 ^mins
66	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	130,928	58,488	2.24	10 ^hrs 43 ^mins
67	Quadro K4200 GK104 [Quadro K4200]	Nvidia	GK104	117,287	57,009	2.06	11 ^hrs 40 ^mins
68	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	114,767	55,651	2.06	11 ^hrs 38 ^mins
69	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	114,514	56,021	2.04	11 ^hrs 44 ^mins
70	Radeon RX 460 Baffin XT [Radeon RX 460]	AMD	Baffin XT	114,423	55,907	2.05	11 ^hrs 44 ^mins
71	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	110,954	55,370	2.00	11 ^hrs 59 ^mins
72	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	96,097	52,826	1.82	13 ^hrs 12 ^mins
73	GeForce GTX 760 GK104 [GeForce GTX 760] 2258	Nvidia	GK104	87,540	39,413	2.22	10 ^hrs 48 ^mins
74	Radeon R7 240/HD8570 Hawaii [Radeon R7 240/HD8570]	AMD	Hawaii	65,577	24,972	2.63	9 ^hrs 8 ^mins
75	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	62,005	45,515	1.36	17 ^hrs 37 ^mins
76	Ryzen vega 8 mobile Raven [Ryzen vega 8 mobile]	AMD	Raven	49,371	42,390	1.16	20 ^hrs 36 ^mins
77	Radeon R7 250X/HD 7700/8760 R575A [Radeon R7 250X/HD 7700/8760]	AMD	R575A	48,197	41,932	1.15	20 ^hrs 53 ^mins
78	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	45,169	40,935	1.10	21 ^hrs 45 ^mins
79	GeForce GTX 560 Ti GF114 [GeForce GTX 560 Ti]	Nvidia	GF114	40,258	39,484	1.02	23 ^hrs 32 ^mins

80	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	36,839	37,438	0.98	24 ^hrs 23 ^mins
81	Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902]	AMD	raven	32,034	36,314	0.88	27 ^hrs 12 ^mins
82	GeForce GTX 550 Ti GF116 [GeForce GTX 550 Ti] 691	Nvidia	GF116	20,349	31,305	0.65	36 ^hrs 55 ^mins
83	GeForce GTS 450 GF106 [GeForce GTS 450]	Nvidia	GF106	10,165	20,377	0.50	48 ^hrs 7 ^mins
84	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	1,769	20,300	0.09	275 ^hrs 25 ^mins

Research: MYOSINS Folding Project #17426

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17426

GPU PPD Averages

Research: MYOSINS Folding Project #17426

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages