Folding project #17431, MYOSINS research

Research section Research projects and references

Project #17431 overview

Project Summary AI Beta

This project studies myosins, proteins that power muscle contractions and cell movement. Scientists want to understand how drugs can fix problems with myosins that cause heart conditions like cardiomyopathy and heart failure. Myosins are so important they were even named Molecule of the Month by scientists!

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 171,010
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Myosins

Proteins responsible for force generation in the body.

Technical: Pharmaceutical ResearchBiotechnology / Molecular Biology

Myosins are a type of protein that plays a crucial role in various bodily functions. They are responsible for generating force, enabling muscle contraction, and facilitating the movement of materials within cells. Defects in myosin function can lead to several medical conditions, including cardiomyopathies (heart diseases) and heart failure. Researchers are actively exploring ways to develop drugs that target myosins to treat these diseases.

Cardiomyopathies

Diseases of the heart muscle.

Medical: HealthcareBiomedicine / Cardiology

Cardiomyopathies are a group of diseases that affect the heart muscle, making it harder for the heart to pump blood effectively. There are different types of cardiomyopathies, including hypertrophic cardiomyopathy (thickening of the heart muscle) and dilated cardiomyopathy (enlargement of the heart chambers). These conditions can lead to symptoms such as shortness of breath, fatigue, and chest pain. Treatment options may include medications, lifestyle changes, or in some cases, surgery.

Heart Failure

A condition where the heart cannot pump blood effectively.

Medical: HealthcareBiomedicine / Cardiology

Heart failure is a serious condition that occurs when the heart muscle weakens and can't pump enough blood to meet the body's needs. This can lead to fluid buildup in the lungs and other parts of the body, causing symptoms such as shortness of breath, fatigue, and swelling. Treatment options for heart failure include medications, lifestyle changes, and sometimes surgery or a heart transplant.

Proteins

Large biomolecules essential for all biological processes.

Scientific: Pharmaceutical ResearchBiotechnology / Molecular Biology

Proteins are complex molecules that play a vital role in virtually every aspect of life. They perform a wide range of functions, including building and repairing tissues, transporting substances, catalyzing chemical reactions, and providing structural support. Proteins are made up of chains of amino acids, which are linked together in specific sequences determined by genes.

PDB

Protein Data Bank

Acronym: Scientific ResearchBiotechnology / Structural Biology

The Protein Data Bank (PDB) is a global repository that stores and distributes 3-dimensional structural information about proteins. This data is essential for understanding protein function and designing new drugs and therapies.

June

Sixth month of the year.

Calendar: N/AN/A / Time

June is the sixth month of the year in the Gregorian calendar. It is typically a warm and sunny month in many parts of the world.

2001

The year 2001.

Year: N/AN/A / Time

2001 was a common year that began on a Sunday. It was notable for events such as the September 11 terrorist attacks and the beginning of the War in Afghanistan.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,559,525	214,048	30.65	0 ^hrs 47 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,140,022	197,306	26.05	0 ^hrs 55 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,755,714	193,719	24.55	0 ^hrs 59 ^mins
4	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,150,068	185,871	22.33	1 ^hrs 4 ^mins
5	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,588,181	176,038	20.38	1 ^hrs 11 ^mins
6	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	3,503,088	173,947	20.14	1 ^hrs 12 ^mins
7	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,456,775	174,637	19.79	1 ^hrs 13 ^mins
8	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,175,332	171,021	18.57	1 ^hrs 18 ^mins
9	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,059,935	167,252	18.30	1 ^hrs 19 ^mins
10	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,986,349	166,714	17.91	1 ^hrs 20 ^mins
11	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,767,369	162,569	17.02	1 ^hrs 25 ^mins
12	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,591,962	159,001	16.30	1 ^hrs 28 ^mins
13	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,535,701	154,536	16.41	1 ^hrs 28 ^mins
14	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,271,752	152,502	14.90	1 ^hrs 37 ^mins
15	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,209,972	148,985	14.83	1 ^hrs 37 ^mins
16	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,132,290	148,889	14.32	1 ^hrs 41 ^mins
17	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	1,858,552	137,952	13.47	1 ^hrs 47 ^mins
18	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,854,834	139,670	13.28	1 ^hrs 48 ^mins
19	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,823,751	141,699	12.87	1 ^hrs 52 ^mins

20	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,754,525	139,275	12.60	1 ^hrs 54 ^mins
21	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,744,288	138,961	12.55	1 ^hrs 55 ^mins
22	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,689,526	136,831	12.35	1 ^hrs 57 ^mins
23	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,392,453	129,295	10.77	2 ^hrs 14 ^mins
24	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,319,469	127,140	10.38	2 ^hrs 19 ^mins
25	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,308,702	126,954	10.31	2 ^hrs 20 ^mins
26	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,222,976	123,213	9.93	2 ^hrs 25 ^mins
27	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	1,217,308	123,972	9.82	2 ^hrs 27 ^mins
28	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,150,918	121,317	9.49	2 ^hrs 32 ^mins
29	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,102,399	117,714	9.37	2 ^hrs 34 ^mins
30	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,059,174	118,076	8.97	2 ^hrs 41 ^mins
31	GeForce GTX 1070 Mobile GP104M [GeForce GTX 1070 Mobile]	Nvidia	GP104M	973,318	115,128	8.45	2 ^hrs 50 ^mins
32	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	903,349	110,958	8.14	2 ^hrs 57 ^mins
33	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	863,540	108,110	7.99	3 ^hrs 0 ^mins
34	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	801,935	104,732	7.66	3 ^hrs 8 ^mins
35	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	743,192	105,074	7.07	3 ^hrs 24 ^mins
36	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	738,783	104,101	7.10	3 ^hrs 23 ^mins
37	P104-100 GP104 [P104-100]	Nvidia	GP104	692,923	102,404	6.77	3 ^hrs 33 ^mins
38	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	644,273	100,119	6.44	3 ^hrs 44 ^mins
39	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	603,018	97,474	6.19	3 ^hrs 53 ^mins

40	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	597,699	91,687	6.52	3 ^hrs 41 ^mins
41	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	583,150	96,262	6.06	3 ^hrs 58 ^mins
42	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	565,667	92,646	6.11	3 ^hrs 56 ^mins
43	P106-100 GP106 [P106-100]	Nvidia	GP106	488,659	91,183	5.36	4 ^hrs 29 ^mins
44	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	485,268	89,404	5.43	4 ^hrs 25 ^mins
45	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	472,152	90,375	5.22	4 ^hrs 36 ^mins
46	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	471,228	90,304	5.22	4 ^hrs 36 ^mins
47	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	435,379	87,356	4.98	4 ^hrs 49 ^mins
48	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	420,059	85,417	4.92	4 ^hrs 53 ^mins
49	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	374,059	83,333	4.49	5 ^hrs 21 ^mins
50	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	347,344	79,598	4.36	5 ^hrs 30 ^mins
51	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	327,134	32,671	10.01	2 ^hrs 24 ^mins
52	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	307,230	78,284	3.92	6 ^hrs 7 ^mins
53	P106-090 GP106 [P106-090]	Nvidia	GP106	293,665	76,822	3.82	6 ^hrs 17 ^mins
54	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	255,354	73,284	3.48	6 ^hrs 53 ^mins
55	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	245,166	72,635	3.38	7 ^hrs 7 ^mins
56	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	225,350	70,355	3.20	7 ^hrs 30 ^mins
57	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	204,962	67,535	3.03	7 ^hrs 54 ^mins
58	Radeon RX Vega M XL [Radeon RX Vega M XL]	AMD	Vega	168,857	60,824	2.78	8 ^hrs 39 ^mins
59	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	167,090	63,909	2.61	9 ^hrs 11 ^mins

60	Radeon R9 200 Series Hawaii [Radeon R9 200 Series]	AMD	Hawaii	166,833	63,644	2.62	9 ^hrs 9 ^mins
61	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	158,745	62,795	2.53	9 ^hrs 30 ^mins
62	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	144,917	60,984	2.38	10 ^hrs 6 ^mins
63	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	136,429	59,620	2.29	10 ^hrs 29 ^mins
64	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	116,011	56,546	2.05	11 ^hrs 42 ^mins
65	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	112,535	56,025	2.01	11 ^hrs 57 ^mins
66	Radeon R7 200 Series Hawaii [Radeon R7 200 Series]	AMD	Hawaii	103,135	51,908	1.99	12 ^hrs 5 ^mins
67	Quadro K4200 GK104 [Quadro K4200]	Nvidia	GK104	99,578	51,804	1.92	12 ^hrs 29 ^mins
68	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	98,622	53,628	1.84	13 ^hrs 3 ^mins
69	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	63,273	46,280	1.37	17 ^hrs 33 ^mins
70	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	31,558	31,730	0.99	24 ^hrs 8 ^mins
71	Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902]	AMD	raven	19,984	32,561	0.61	39 ^hrs 6 ^mins

Research: MYOSINS Folding Project #17431

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17431

GPU PPD Averages

Research: MYOSINS Folding Project #17431

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages