Folding project #17433, MYOSINS research

Research section Research projects and references

Project #17433 overview

Project Summary AI Beta

This project studies myosins, proteins that power movement in our bodies, from muscle contractions to cell activity. Researchers want to understand how drugs could fix problems with myosin linked to heart conditions like cardiomyopathies and heart failure. Myosin is so important it was even featured as the Molecule of the Month by the Protein Data Bank!

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 272,122
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

myosins

Proteins responsible for muscle contraction and cellular movement.

Scientific: PharmaceuticalBiotechnology / Cellular Biology

Myosins are a family of motor proteins crucial for various biological processes. They generate force and enable the movement of cells, organelles, and materials within cells. Myosins play a vital role in muscle contraction, cell division, and intracellular transport. Dysfunctional myosins can contribute to diseases like cardiomyopathies and heart failure.

proteins

Large biomolecules essential for all life processes.

Scientific: PharmaceuticalBiotechnology / Molecular Biology

Proteins are complex molecules made up of amino acids. They perform a wide range of functions in living organisms, including catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes. Proteins are crucial for the structure, function, and regulation of all cells.

cardiomyopathies

Diseases of the heart muscle.

Medical: PharmaceuticalMedicine / Cardiology

Cardiomyopathies are a group of diseases that affect the heart muscle, making it harder for the heart to pump blood effectively. Symptoms can include shortness of breath, fatigue, and swelling in the legs or ankles. There are different types of cardiomyopathies, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and restrictive cardiomyopathy.

heart failure

A serious condition where the heart can't pump enough blood to meet the body's needs.

Medical: PharmaceuticalMedicine / Cardiology

Heart failure occurs when the heart muscle weakens and can't pump blood effectively. This can lead to fatigue, shortness of breath, swelling in the legs, and other symptoms. There are different types of heart failure, and treatment options depend on the underlying cause.

PDB

Protein Data Bank

Acronym: Scientific ResearchBiotechnology / Structural Biology

The Protein Data Bank (PDB) is a global repository of 3D structural information about biological macromolecules, primarily proteins and nucleic acids. It provides a vast resource for researchers studying protein structure, function, and interactions.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,879,978	377,688	18.22	1 ^hrs 19 ^mins
2	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	6,272,173	366,033	17.14	1 ^hrs 24 ^mins
3	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,538,767	353,608	15.66	1 ^hrs 32 ^mins
4	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,308,925	351,284	15.11	1 ^hrs 35 ^mins
5	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	4,307,780	328,065	13.13	1 ^hrs 50 ^mins
6	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,267,494	325,401	13.11	1 ^hrs 50 ^mins
7	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,025,054	320,053	12.58	1 ^hrs 55 ^mins
8	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,844,794	315,149	12.20	1 ^hrs 58 ^mins
9	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,439,434	303,643	11.33	2 ^hrs 7 ^mins
10	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,184,553	295,428	10.78	2 ^hrs 14 ^mins
11	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,933,322	288,378	10.17	2 ^hrs 22 ^mins
12	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,823,845	284,673	9.92	2 ^hrs 25 ^mins
13	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,740,393	277,413	9.88	2 ^hrs 26 ^mins
14	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,690,072	280,147	9.60	2 ^hrs 30 ^mins
15	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,686,378	279,953	9.60	2 ^hrs 30 ^mins
16	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	2,578,111	273,882	9.41	2 ^hrs 33 ^mins
17	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,365,351	267,674	8.84	2 ^hrs 43 ^mins
18	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,343,719	267,300	8.77	2 ^hrs 44 ^mins
19	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	2,279,664	266,015	8.57	2 ^hrs 48 ^mins

20	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,240,008	261,881	8.55	2 ^hrs 48 ^mins
21	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	2,107,415	251,288	8.39	2 ^hrs 52 ^mins
22	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,049,121	250,413	8.18	2 ^hrs 56 ^mins
23	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	2,044,109	256,422	7.97	3 ^hrs 1 ^mins
24	Radeon RX 6700/6700 XT / 6800M Navi 22 [Radeon RX 6700/6700 XT / 6800M]	AMD	Navi 22	1,930,120	250,647	7.70	3 ^hrs 7 ^mins
25	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,853,431	241,556	7.67	3 ^hrs 8 ^mins
26	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,829,126	246,277	7.43	3 ^hrs 14 ^mins
27	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,786,867	241,666	7.39	3 ^hrs 15 ^mins
28	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,761,951	243,550	7.23	3 ^hrs 19 ^mins
29	GeForce RTX 3070 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	1,674,578	236,532	7.08	3 ^hrs 23 ^mins
30	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,381,598	224,868	6.14	3 ^hrs 54 ^mins
31	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,364,853	221,623	6.16	3 ^hrs 54 ^mins
32	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,313,139	215,539	6.09	3 ^hrs 56 ^mins
33	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	1,295,840	219,788	5.90	4 ^hrs 4 ^mins
34	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,230,250	203,461	6.05	3 ^hrs 58 ^mins
35	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,213,700	214,252	5.66	4 ^hrs 14 ^mins
36	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,213,472	215,122	5.64	4 ^hrs 15 ^mins
37	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,121,698	209,824	5.35	4 ^hrs 29 ^mins
38	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,088,947	206,578	5.27	4 ^hrs 33 ^mins
39	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	1,073,278	204,017	5.26	4 ^hrs 34 ^mins

40	GeForce GTX 1070 Mobile GP104M [GeForce GTX 1070 Mobile]	Nvidia	GP104M	1,022,660	203,559	5.02	4 ^hrs 47 ^mins
41	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	980,699	199,241	4.92	4 ^hrs 53 ^mins
42	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	907,702	189,466	4.79	5 ^hrs 1 ^mins
43	P104-100 GP104 [P104-100]	Nvidia	GP104	836,767	190,030	4.40	5 ^hrs 27 ^mins
44	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	832,000	188,802	4.41	5 ^hrs 27 ^mins
45	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	728,403	181,604	4.01	5 ^hrs 59 ^mins
46	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	683,809	177,469	3.85	6 ^hrs 14 ^mins
47	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	677,561	176,521	3.84	6 ^hrs 15 ^mins
48	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	597,044	168,032	3.55	6 ^hrs 45 ^mins
49	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	590,455	158,682	3.72	6 ^hrs 27 ^mins
50	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	574,673	167,307	3.43	6 ^hrs 59 ^mins
51	P106-100 GP106 [P106-100]	Nvidia	GP106	562,365	166,501	3.38	7 ^hrs 6 ^mins
52	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	517,407	156,712	3.30	7 ^hrs 16 ^mins
53	Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q]	Nvidia	TU117GLM	505,805	160,922	3.14	7 ^hrs 38 ^mins
54	GeForce GTX 1650 TU117 [GeForce GTX 1650] 3091	Nvidia	TU117	501,788	137,029	3.66	6 ^hrs 33 ^mins
55	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	501,251	158,339	3.17	7 ^hrs 35 ^mins
56	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	444,747	158,020	2.81	8 ^hrs 32 ^mins
57	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	440,605	152,959	2.88	8 ^hrs 20 ^mins
58	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	434,415	152,736	2.84	8 ^hrs 26 ^mins
59	GeForce GTX 780 GK110 [GeForce GTX 780] 3977	Nvidia	GK110	393,029	145,497	2.70	8 ^hrs 53 ^mins

60	Tesla K20M GK110 [Tesla K20M] 3524	Nvidia	GK110	374,022	145,400	2.57	9 ^hrs 20 ^mins
61	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	362,020	134,178	2.70	8 ^hrs 54 ^mins
62	P106-090 GP106 [P106-090]	Nvidia	GP106	336,853	140,473	2.40	10 ^hrs 1 ^mins
63	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	329,892	139,357	2.37	10 ^hrs 8 ^mins
64	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	326,666	139,159	2.35	10 ^hrs 13 ^mins
65	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	314,572	100,124	3.14	7 ^hrs 38 ^mins
66	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	309,676	136,549	2.27	10 ^hrs 35 ^mins
67	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	307,179	134,021	2.29	10 ^hrs 28 ^mins
68	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	287,713	133,355	2.16	11 ^hrs 7 ^mins
69	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	283,975	132,783	2.14	11 ^hrs 13 ^mins
70	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	275,043	127,622	2.16	11 ^hrs 8 ^mins
71	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	273,708	131,307	2.08	11 ^hrs 31 ^mins
72	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	270,473	129,746	2.08	11 ^hrs 31 ^mins
73	GeForce GTX 690 GK104 [GeForce GTX 690] 3130	Nvidia	GK104	246,767	126,524	1.95	12 ^hrs 18 ^mins
74	GeForce GTX 670/GTX 760Ti OEM GK104 [GeForce GTX 670/GTX 760Ti OEM] 2634	Nvidia	GK104	222,156	122,515	1.81	13 ^hrs 14 ^mins
75	Radeon RX Vega M XL [Radeon RX Vega M XL]	AMD	Vega	210,534	119,736	1.76	13 ^hrs 39 ^mins
76	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	187,682	115,226	1.63	14 ^hrs 44 ^mins
77	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	167,197	111,261	1.50	15 ^hrs 58 ^mins
78	GeForce GTX 760 GK104 [GeForce GTX 760] 2258	Nvidia	GK104	157,028	105,675	1.49	16 ^hrs 9 ^mins
79	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	153,333	108,039	1.42	16 ^hrs 55 ^mins

80	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	151,133	107,116	1.41	17 ^hrs 1 ^mins
81	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	147,135	106,508	1.38	17 ^hrs 22 ^mins
82	GeForce GTX 660 GK106 [GeForce GTX 660]	Nvidia	GK106	143,281	104,596	1.37	17 ^hrs 31 ^mins
83	Radeon RX 460 Baffin XT [Radeon RX 460]	AMD	Baffin XT	131,391	102,617	1.28	18 ^hrs 45 ^mins
84	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	128,713	101,981	1.26	19 ^hrs 1 ^mins
85	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	123,273	90,434	1.36	17 ^hrs 36 ^mins
86	GTX 650 Ti Boost GK106 [GTX 650 Ti Boost]	Nvidia	GK106	119,930	99,254	1.21	19 ^hrs 52 ^mins
87	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	111,905	97,118	1.15	20 ^hrs 50 ^mins
88	Radeon Rx 270/370 Curacao Pro [Radeon Rx 270/370]	AMD	Curacao Pro	91,542	82,122	1.11	21 ^hrs 32 ^mins
89	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	65,277	80,976	0.81	29 ^hrs 46 ^mins
90	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	34,805	58,709	0.59	40 ^hrs 29 ^mins
91	Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902]	AMD	raven	20,465	47,000	0.44	55 ^hrs 7 ^mins
92	GeForce 920M GK208 [GeForce 920M]	Nvidia	GK208	19,544	46,100	0.42	56 ^hrs 37 ^mins
93	GeForce GTX 670M GF114 [GeForce GTX 670M]	Nvidia	GF114	15,829	47,000	0.34	71 ^hrs 16 ^mins
94	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	11,576	47,000	0.25	97 ^hrs 27 ^mins
95	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	5,626	47,000	0.12	200 ^hrs 30 ^mins

Research: MYOSINS Folding Project #17433

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17433

GPU PPD Averages

Research: MYOSINS Folding Project #17433

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages