PROJECT #17261 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process..

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 84,276

Core: 0xa8

Status: Public