PROJECT #17261 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process..

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 84,276

Core: 0xa8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 04 December 2022 18:13:25

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 04 December 2022 18:13:25

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5950X 16-CORE 32 23,479 751,328 AMD
2 12TH GEN CORE I9-12900K 24 26,610 638,640 Intel
3 RYZEN 9 3900 12-CORE 24 26,594 638,256 AMD
4 RYZEN 9 5900X 12-CORE 24 25,326 607,824 AMD
5 12TH GEN CORE I7-12700K 20 24,567 491,340 Intel
6 RYZEN 9 3900XT 12-CORE 24 19,199 460,776 AMD
7 RYZEN 7 5800X 8-CORE 16 26,656 426,496 AMD
8 11TH GEN CORE I7-11700K @ 3.60GHZ 16 24,965 399,440 Intel
9 RYZEN 7 5700X 8-CORE 16 23,570 377,120 AMD
10 CORE I9-10900X CPU @ 3.70GHZ 20 17,732 354,640 Intel
11 12TH GEN CORE I5-12600K 16 20,980 335,680 Intel
12 RYZEN 7 3800X 8-CORE 16 20,860 333,760 AMD
13 RYZEN 7 5800H 16 17,307 276,912 AMD
14 APPLE M1 MAX 10 24,777 247,770 Apple
15 CORE I7-8700 CPU @ 3.20GHZ 12 18,072 216,864 Intel
16 RYZEN 9 3900X 12-CORE 24 8,636 207,264 AMD
17 RYZEN 7 PRO 4750G 16 12,840 205,440 AMD
18 RYZEN 7 3700X 8-CORE 16 12,216 195,456 AMD
19 RYZEN 5 5600X 6-CORE 12 15,144 181,728 AMD
20 XEON GOLD 6128 CPU @ 3.40GHZ 12 14,713 176,556 Intel
21 RYZEN 5 3600 6-CORE 12 13,390 160,680 AMD
22 CORE I7-7700K CPU @ 4.20GHZ 8 17,800 142,400 Intel
23 CORE I7-8705G CPU @ 3.10GHZ 8 17,709 141,672 Intel
24 CORE I7-10700T CPU @ 2.00GHZ 16 8,197 131,152 Intel
25 CORE I7-10710U CPU @ 1.10GHZ 12 10,279 123,348 Intel
26 CORE I7-6700 CPU @ 3.40GHZ 8 15,210 121,680 Intel
27 CORE I5-10400 CPU @ 2.90GHZ 12 8,495 101,940 Intel
28 CORE I3-9100F CPU @ 3.60GHZ 4 24,536 98,144 Intel
29 11TH GEN CORE I5-11400 @ 2.60GHZ 12 7,431 89,172 Intel
30 CORE I9-8950HK CPU @ 2.90GHZ 12 6,708 80,496 Intel
31 APPLE M1 8 9,698 77,584 Apple
32 XEON CPU E5-1630 V3 @ 3.70GHZ 8 9,405 75,240 Intel
33 XEON CPU E5-2680 0 @ 2.70GHZ 16 4,106 65,696 Intel
34 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,546 60,368 Intel
35 CORE I5-7400 CPU @ 3.00GHZ 4 14,598 58,392 Intel
36 APPLE M1 PRO 10 5,225 52,250 Apple
37 CORE I5-4590 CPU @ 3.30GHZ 4 12,980 51,920 Intel
38 CORE I5-4690 CPU @ 3.50GHZ 4 12,820 51,280 Intel
39 CORE I5-4570 CPU @ 3.20GHZ 4 11,131 44,524 Intel
40 CORE I5-6600K CPU @ 3.50GHZ 4 10,821 43,284 Intel
41 CORE I5-6400 CPU @ 2.70GHZ 4 10,120 40,480 Intel
42 XEON CPU E3-1240 V2 @ 3.40GHZ 8 4,803 38,424 Intel
43 CORE I5-3570K CPU @ 3.40GHZ 4 7,548 30,192 Intel
44 CORE I5-4278U CPU @ 2.60GHZ 4 6,981 27,924 Intel
45 CORE I3-6006U CPU @ 2.00GHZ 4 2,704 10,816 Intel
46 CORE I5 CPU M 430 @ 2.27GHZ 4 1,644 6,576 Intel