PROJECT #17261 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process..

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 84,276

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 27 June 2022 11:45:23

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 27 June 2022 11:45:23

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5900X 12-CORE 24 45,936 1,102,464 AMD
2 12TH GEN CORE I9-12900K 24 20,546 493,104 Intel
3 RYZEN 9 3900XT 12-CORE 24 19,157 459,768 AMD
4 11TH GEN CORE I7-11700K @ 3.60GHZ 16 24,936 398,976 Intel
5 CORE I9-10900X CPU @ 3.70GHZ 20 18,717 374,340 Intel
6 RYZEN 7 3700X 8-CORE 16 18,265 292,240 AMD
7 CORE I7-8700 CPU @ 3.20GHZ 12 17,934 215,208 Intel
8 RYZEN 9 3900X 12-CORE 24 8,636 207,264 AMD
9 RYZEN 7 PRO 4750G 16 10,828 173,248 AMD
10 CORE I5-10400 CPU @ 2.90GHZ 12 8,495 101,940 Intel
11 CORE I3-9100F CPU @ 3.60GHZ 4 24,536 98,144 Intel
12 CORE I5-7400 CPU @ 3.00GHZ 4 15,942 63,768 Intel
13 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,546 60,368 Intel
14 XEON CPU E5-2680 0 @ 2.70GHZ 16 3,772 60,352 Intel
15 CORE I5-4590 CPU @ 3.30GHZ 4 12,873 51,492 Intel
16 CORE I5-4570 CPU @ 3.20GHZ 4 11,811 47,244 Intel
17 CORE I5-6600K CPU @ 3.50GHZ 4 10,423 41,692 Intel
18 CORE I5 CPU M 430 @ 2.27GHZ 4 1,644 6,576 Intel