PROJECT #17210 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 57,065

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:10

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:10

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 18,689 897,072 AMD
2 RYZEN 9 5950X 16-CORE 32 15,444 494,208 AMD
3 RYZEN 9 3950X 16-CORE 32 11,794 377,408 AMD
4 RYZEN 9 3900X 12-CORE 24 14,302 343,248 AMD
5 RYZEN 7 3800X 8-CORE 16 13,691 219,056 AMD
6 CORE I9-10900X CPU @ 3.70GHZ 20 9,569 191,380 Intel
7 RYZEN THREADRIPPER 1920X 12-CORE 24 6,975 167,400 AMD
8 CORE I9-9900KF CPU @ 3.60GHZ 16 10,166 162,656 Intel
9 RYZEN 7 3700X 8-CORE 16 8,948 143,168 AMD
10 CORE I9-7940X CPU @ 3.10GHZ 28 4,424 123,872 Intel
11 RYZEN 5 3600XT 6-CORE 12 9,936 119,232 AMD
12 RYZEN 5 3600 6-CORE 12 9,438 113,256 AMD
13 XEON CPU E5-2686 V4 @ 2.30GHZ 36 3,001 108,036 Intel
14 RYZEN 7 2700X EIGHT-CORE 16 6,303 100,848 AMD
15 RYZEN 5 3500 6-CORE 6 13,361 80,166 AMD
16 CORE I5-10400F CPU @ 2.90GHZ 12 6,585 79,020 Intel
17 CORE I7-10710U CPU @ 1.10GHZ 12 5,535 66,420 Intel
18 CORE I5-8400 CPU @ 2.80GHZ 6 10,061 60,366 Intel
19 XEON CPU E5-2620 V2 @ 2.10GHZ 24 2,487 59,688 Intel
20 CORE I5-7600 CPU @ 3.50GHZ 4 11,347 45,388 Intel
21 RYZEN 5 3500U 8 851 6,808 AMD