PROJECT #17212 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 57,071

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 27 January 2021 18:45:57

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 27 January 2021 18:45:58

Rank Project	CPU Model	Logical Processors (LP)	PPD-PLP AVG PPD per 1 LP	ALL LP-PPD (Estimated)	Make
1	RYZEN 9 5950X 16-CORE	32	20,236	647,552	AMD
2	RYZEN 9 3950X 16-CORE	32	15,240	487,680	AMD
3	RYZEN 9 5900X 12-CORE	24	19,608	470,592	AMD
4	RYZEN 9 3900X 12-CORE	24	14,783	354,792	AMD
5	CORE I9-9980XE CPU @ 3.00GHZ	36	9,665	347,940	Intel
6	CORE I9-9900K CPU @ 3.60GHZ	16	17,476	279,616	Intel
7	XEON CPU E5-2686 V4 @ 2.30GHZ	36	7,211	259,596	Intel
8	CORE I9-9900KF CPU @ 3.60GHZ	16	10,918	174,688	Intel
9	RYZEN 5 3600X 6-CORE	12	13,334	160,008	AMD
10	XEON W-2245 CPU @ 3.90GHZ	16	9,661	154,576	Intel
11	RYZEN 7 3700X 8-CORE	16	9,587	153,392	AMD
12	RYZEN 5 3600 6-CORE	12	11,181	134,172	AMD
13	RYZEN 7 2700X EIGHT-CORE	16	7,798	124,768	AMD
14	RYZEN 7 5800X 8-CORE	16	7,328	117,248	AMD
15	XEON CPU E5-2620 V2 @ 2.10GHZ	24	2,662	63,888	Intel
16	RYZEN 7 1700X EIGHT-CORE	16	3,945	63,120	AMD
17	CORE I7-8550U CPU @ 1.80GHZ	8	7,372	58,976	Intel
18	CORE I7-6700K CPU @ 4.00GHZ	8	6,245	49,960	Intel
19	FX-8350 EIGHT-CORE	8	2,570	20,560	AMD
20	CORE I5-2500K CPU @ 3.30GHZ	4	4,760	19,040	Intel

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