PROJECT #17212 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 57,071

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 15 April 2021 07:35:55

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 15 April 2021 07:35:55

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5950X 16-CORE 32 20,236 647,552 AMD
2 RYZEN 9 3950X 16-CORE 32 15,240 487,680 AMD
3 RYZEN 9 5900X 12-CORE 24 19,608 470,592 AMD
4 RYZEN 9 3900X 12-CORE 24 14,783 354,792 AMD
5 CORE I9-9980XE CPU @ 3.00GHZ 36 9,665 347,940 Intel
6 CORE I9-9900K CPU @ 3.60GHZ 16 17,476 279,616 Intel
7 XEON CPU E5-2686 V4 @ 2.30GHZ 36 7,211 259,596 Intel
8 CORE I9-9900KF CPU @ 3.60GHZ 16 10,918 174,688 Intel
9 RYZEN 5 3600X 6-CORE 12 13,334 160,008 AMD
10 XEON W-2245 CPU @ 3.90GHZ 16 9,661 154,576 Intel
11 RYZEN 7 3700X 8-CORE 16 9,587 153,392 AMD
12 RYZEN 5 3600 6-CORE 12 11,181 134,172 AMD
13 RYZEN 7 2700X EIGHT-CORE 16 7,798 124,768 AMD
14 RYZEN 7 5800X 8-CORE 16 7,328 117,248 AMD
15 XEON CPU E5-2620 V2 @ 2.10GHZ 24 2,662 63,888 Intel
16 RYZEN 7 1700X EIGHT-CORE 16 3,945 63,120 AMD
17 CORE I7-8550U CPU @ 1.80GHZ 8 7,372 58,976 Intel
18 CORE I7-6700K CPU @ 4.00GHZ 8 6,245 49,960 Intel
19 FX-8350 EIGHT-CORE 8 2,570 20,560 AMD
20 CORE I5-2500K CPU @ 3.30GHZ 4 4,760 19,040 Intel