PROJECT #17212 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.
G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.
When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.
Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.
GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.
in this project, we are studying the mechanism of GDP dissociation process..
PROJECT INFO
Manager(s): Neha Vithani
Institution: Washington University in St. Louis
PROJECT WORK UNIT SUMMARY
Atoms: 57,071
Core: GRO_A7
Status: Public
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Tuesday, 31 January 2023 00:15:02
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PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Tuesday, 31 January 2023 00:15:02