Official Project Description
G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.
G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.
When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.
Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.
GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.
in this project, we are studying the mechanism of GDP dissociation process.