PROJECT #17209 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 116,317

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:10

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:10

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 15,798 758,304 AMD
2 RYZEN 9 5950X 16-CORE 32 15,784 505,088 AMD
3 RYZEN 9 3950X 16-CORE 32 11,159 357,088 AMD
4 CORE I9-9980XE CPU @ 3.00GHZ 36 9,310 335,160 Intel
5 RYZEN 9 3900X 12-CORE 24 13,272 318,528 AMD
6 RYZEN 9 3900XT 12-CORE 24 12,855 308,520 AMD
7 CORE I9-10980XE CPU @ 3.00GHZ 36 6,097 219,492 Intel
8 RYZEN 7 3700X 8-CORE 16 10,774 172,384 AMD
9 RYZEN THREADRIPPER 1920X 12-CORE 24 6,854 164,496 AMD
10 XEON W-2245 CPU @ 3.90GHZ 16 9,854 157,664 Intel
11 RYZEN 7 3800X 8-CORE 16 9,671 154,736 AMD
12 RYZEN 5 3600 6-CORE 12 12,613 151,356 AMD
13 CORE I7-9700 CPU @ 3.00GHZ 8 12,531 100,248 Intel
14 CORE I7-10710U CPU @ 1.10GHZ 12 5,621 67,452 Intel
15 RYZEN 7 1700 EIGHT-CORE 16 4,016 64,256 AMD
16 RYZEN 5 2600X SIX-CORE 12 5,211 62,532 AMD