PROJECT #17226 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 142,200

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 15 April 2021 19:27:06

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 15 April 2021 19:27:06

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 EPYC 7302 16-CORE 64 13,874 887,936 AMD
2 RYZEN 9 3950X 16-CORE 32 24,789 793,248 AMD
3 RYZEN 9 5950X 16-CORE 32 15,796 505,472 AMD
4 RYZEN 9 3900XT 12-CORE 24 15,683 376,392 AMD
5 RYZEN THREADRIPPER 2970WX 24-CORE 48 7,025 337,200 AMD
6 RYZEN 7 5800X 8-CORE 16 18,331 293,296 AMD
7 CORE I9-9900K CPU @ 3.60GHZ 16 16,130 258,080 Intel
8 CORE I7-10700K CPU @ 3.80GHZ 16 13,130 210,080 Intel
9 RYZEN 7 3700X 8-CORE 16 10,706 171,296 AMD
10 RYZEN THREADRIPPER 1920X 12-CORE 24 6,033 144,792 AMD
11 RYZEN 5 3600 6-CORE 12 11,562 138,744 AMD
12 CORE I7-9700K CPU @ 3.60GHZ 8 16,453 131,624 Intel
13 CORE I5-10400F CPU @ 2.90GHZ 12 7,906 94,872 Intel
14 RYZEN 3 3100 4-CORE 8 10,753 86,024 AMD
15 XEON CPU E5-2690 V2 @ 3.00GHZ 20 3,656 73,120 Intel
16 RYZEN 5 2600X SIX-CORE 12 5,340 64,080 AMD
17 RYZEN 5 2600 SIX-CORE 12 5,306 63,672 AMD
18 CORE I7-6700K CPU @ 4.00GHZ 8 7,337 58,696 Intel
19 CORE I7-8705G CPU @ 3.10GHZ 8 7,068 56,544 Intel
20 CORE I7-4770 CPU @ 3.40GHZ 8 5,225 41,800 Intel
21 CORE I7-4790T CPU @ 2.70GHZ 8 4,168 33,344 Intel
22 CORE I5-6500 CPU @ 3.20GHZ 4 8,159 32,636 Intel
23 CORE I5-7600 CPU @ 3.50GHZ 4 7,982 31,928 Intel
24 CORE I5-8250U CPU @ 1.60GHZ 8 3,873 30,984 Intel
25 CORE I5-7400 CPU @ 3.00GHZ 4 7,723 30,892 Intel
26 CORE I3-4160 CPU @ 3.60GHZ 4 3,406 13,624 Intel
27 FX-8320 EIGHT-CORE 8 1,403 11,224 AMD
28 CORE I5-4300U CPU @ 1.90GHZ 4 1,576 6,304 Intel