PROJECT #17226 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 142,200

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 23 July 2021 12:13:39

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 23 July 2021 12:13:39

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 EPYC 7302 16-CORE 64 13,874 887,936 AMD
2 RYZEN 9 3950X 16-CORE 32 25,884 828,288 AMD
3 RYZEN 9 5950X 16-CORE 32 14,932 477,824 AMD
4 RYZEN 9 3900 12-CORE 24 16,587 398,088 AMD
5 RYZEN 9 3900XT 12-CORE 24 15,683 376,392 AMD
6 RYZEN THREADRIPPER 2970WX 24-CORE 48 7,025 337,200 AMD
7 RYZEN 7 5800X 8-CORE 16 18,331 293,296 AMD
8 CORE I9-9900K CPU @ 3.60GHZ 16 16,130 258,080 Intel
9 CORE I7-10700K CPU @ 3.80GHZ 16 13,130 210,080 Intel
10 CORE I9-10900X CPU @ 3.70GHZ 20 10,190 203,800 Intel
11 11TH GEN CORE I7-11700K @ 3.60GHZ 16 12,474 199,584 Intel
12 XEON CPU E5-2690 V4 @ 2.60GHZ 28 6,329 177,212 Intel
13 RYZEN 5 5600X 6-CORE 12 13,984 167,808 AMD
14 RYZEN 7 3700X 8-CORE 16 10,396 166,336 AMD
15 RYZEN THREADRIPPER 1920X 12-CORE 24 6,094 146,256 AMD
16 RYZEN 5 3600 6-CORE 12 11,457 137,484 AMD
17 CORE I7-9700K CPU @ 3.60GHZ 8 16,453 131,624 Intel
18 RYZEN 9 5900X 12-CORE 24 5,339 128,136 AMD
19 RYZEN 7 2700X EIGHT-CORE 16 6,946 111,136 AMD
20 RYZEN 7 PRO 4750G 16 6,904 110,464 AMD
21 CORE I5-10400F CPU @ 2.90GHZ 12 7,906 94,872 Intel
22 RYZEN 3 3100 4-CORE 8 10,753 86,024 AMD
23 XEON CPU E5-2690 V2 @ 3.00GHZ 20 3,656 73,120 Intel
24 11TH GEN CORE I9-11900F @ 2.50GHZ 16 4,006 64,096 Intel
25 RYZEN 5 2600X SIX-CORE 12 5,340 64,080 AMD
26 RYZEN 5 2600 SIX-CORE 12 5,144 61,728 AMD
27 CORE I7-6700K CPU @ 4.00GHZ 8 7,337 58,696 Intel
28 CORE I7-8705G CPU @ 3.10GHZ 8 7,068 56,544 Intel
29 CORE I5-8300H CPU @ 2.30GHZ 8 5,506 44,048 Intel
30 CORE I7-4770 CPU @ 3.40GHZ 8 5,225 41,800 Intel
31 CORE I7-7700 CPU @ 3.60GHZ 8 4,838 38,704 Intel
32 CORE I5-4570S CPU @ 2.90GHZ 4 8,647 34,588 Intel
33 CORE I7-4790T CPU @ 2.70GHZ 8 4,168 33,344 Intel
34 CORE I5-7600 CPU @ 3.50GHZ 4 8,310 33,240 Intel
35 CORE I5-6500 CPU @ 3.20GHZ 4 8,159 32,636 Intel
36 CORE I5-7400 CPU @ 3.00GHZ 4 8,013 32,052 Intel
37 CORE I5-8250U CPU @ 1.60GHZ 8 3,873 30,984 Intel
38 CORE I5-4590 CPU @ 3.30GHZ 4 7,369 29,476 Intel
39 XEON CPU W3550 @ 3.07GHZ 8 3,236 25,888 Intel
40 CORE I3-7100 CPU @ 3.90GHZ 4 5,095 20,380 Intel
41 CORE I3-4160 CPU @ 3.60GHZ 4 3,406 13,624 Intel
42 FX-8320 EIGHT-CORE 8 1,403 11,224 AMD
43 CORE I5-4300U CPU @ 1.90GHZ 4 1,576 6,304 Intel