PROJECT #17221 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 142,184

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 25 February 2021 22:51:39

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 25 February 2021 22:51:39

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5950X 16-CORE 32 15,826 506,432 AMD
2 RYZEN 9 3900X 12-CORE 24 12,488 299,712 AMD
3 RYZEN 7 3700X 8-CORE 16 12,808 204,928 AMD
4 RYZEN 7 3800X 8-CORE 16 10,682 170,912 AMD
5 RYZEN 5 3600 6-CORE 12 11,236 134,832 AMD
6 XEON CPU E5-2660 0 @ 2.20GHZ 32 4,039 129,248 Intel
7 RYZEN 5 1600 SIX-CORE 12 5,291 63,492 AMD
8 CORE I7-6800K CPU @ 3.40GHZ 12 5,097 61,164 Intel
9 CORE I7-4770K CPU @ 3.50GHZ 8 7,276 58,208 Intel
10 CORE I3-9100F CPU @ 3.60GHZ 4 12,478 49,912 Intel
11 CORE I5-6500 CPU @ 3.20GHZ 4 12,030 48,120 Intel
12 CORE I7-6700 CPU @ 3.40GHZ 8 5,414 43,312 Intel
13 CORE I5-7600 CPU @ 3.50GHZ 4 9,038 36,152 Intel
14 CORE I7-3770 CPU @ 3.40GHZ 8 3,743 29,944 Intel
15 CORE I5-6600K CPU @ 3.50GHZ 4 5,996 23,984 Intel
 

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