PROJECT #17221 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 142,184

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:10

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:10

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5950X 16-CORE 32 16,345 523,040 AMD
2 RYZEN 9 5900X 12-CORE 24 19,365 464,760 AMD
3 RYZEN 9 3900X 12-CORE 24 12,488 299,712 AMD
4 RYZEN THREADRIPPER 2970WX 24-CORE 48 5,778 277,344 AMD
5 RYZEN 7 3700X 8-CORE 16 12,140 194,240 AMD
6 RYZEN 7 3800X 8-CORE 16 10,932 174,912 AMD
7 RYZEN 5 3600 6-CORE 12 11,364 136,368 AMD
8 CORE I7-9700K CPU @ 3.60GHZ 8 16,609 132,872 Intel
9 XEON CPU E5-2660 0 @ 2.20GHZ 32 4,039 129,248 Intel
10 RYZEN 7 2700X EIGHT-CORE 16 5,717 91,472 AMD
11 XEON CPU E5-2620 V2 @ 2.10GHZ 24 3,278 78,672 Intel
12 RYZEN 5 2600X SIX-CORE 12 6,533 78,396 AMD
13 CORE I7-4790K CPU @ 4.00GHZ 8 8,151 65,208 Intel
14 RYZEN 5 1600 SIX-CORE 12 5,291 63,492 AMD
15 CORE I5-9400F CPU @ 2.90GHZ 6 10,516 63,096 Intel
16 CORE I7-6800K CPU @ 3.40GHZ 12 5,097 61,164 Intel
17 CORE I7-4770K CPU @ 3.50GHZ 8 7,276 58,208 Intel
18 CORE I7-8705G CPU @ 3.10GHZ 8 7,083 56,664 Intel
19 CORE I3-9100F CPU @ 3.60GHZ 4 12,478 49,912 Intel
20 CORE I7-6700K CPU @ 4.00GHZ 8 6,175 49,400 Intel
21 CORE I7-6700 CPU @ 3.40GHZ 8 5,414 43,312 Intel
22 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 5,408 43,264 Intel
23 CORE I5-7600 CPU @ 3.50GHZ 4 9,038 36,152 Intel
24 CORE I5-6500 CPU @ 3.20GHZ 4 8,758 35,032 Intel
25 CORE I7-3770 CPU @ 3.40GHZ 8 3,743 29,944 Intel
26 CORE I5-6600K CPU @ 3.50GHZ 4 6,606 26,424 Intel