PROJECT #17229 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 142,326

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Saturday, 08 May 2021 01:41:40

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Saturday, 08 May 2021 01:41:40

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 7 4800H 16 54,575 873,200 AMD
2 RYZEN 9 3950X 16-CORE 32 26,841 858,912 AMD
3 RYZEN 9 5950X 16-CORE 32 22,201 710,432 AMD
4 RYZEN 9 3900 12-CORE 24 16,575 397,800 AMD
5 RYZEN THREADRIPPER 2970WX 24-CORE 48 7,301 350,448 AMD
6 RYZEN 7 5800X 8-CORE 16 19,964 319,424 AMD
7 RYZEN 5 5600X 6-CORE 12 15,355 184,260 AMD
8 CORE I7-10700K CPU @ 3.80GHZ 16 9,504 152,064 Intel
9 RYZEN 5 3600 6-CORE 12 10,001 120,012 AMD
10 RYZEN 7 2700X EIGHT-CORE 16 6,367 101,872 AMD
11 RYZEN 5 2600X SIX-CORE 12 6,237 74,844 AMD
12 RYZEN 3 3100 4-CORE 8 9,282 74,256 AMD
13 CORE I5-10400F CPU @ 2.90GHZ 12 5,619 67,428 Intel
14 CORE I7-6700K CPU @ 4.00GHZ 8 7,459 59,672 Intel
15 CORE I5-7600 CPU @ 3.50GHZ 4 9,976 39,904 Intel
16 XEON CPU W3550 @ 3.07GHZ 8 3,070 24,560 Intel
17 CORE I3-7100 CPU @ 3.90GHZ 4 4,747 18,988 Intel
18 CORE I5-7360U CPU @ 2.30GHZ 4 3,428 13,712 Intel