PROJECT #17229 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 142,326

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 25 July 2021 21:22:55

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 25 July 2021 21:22:55

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 7 4800H 16 54,575 873,200 AMD
2 RYZEN 9 3950X 16-CORE 32 27,123 867,936 AMD
3 RYZEN 9 5950X 16-CORE 32 16,645 532,640 AMD
4 RYZEN THREADRIPPER 3960X 24-CORE 48 8,977 430,896 AMD
5 RYZEN 9 3900 12-CORE 24 16,649 399,576 AMD
6 RYZEN THREADRIPPER 2970WX 24-CORE 48 7,301 350,448 AMD
7 RYZEN 7 5800X 8-CORE 16 19,276 308,416 AMD
8 CORE I9-10900X CPU @ 3.70GHZ 20 10,036 200,720 Intel
9 RYZEN 5 5600X 6-CORE 12 15,355 184,260 AMD
10 XEON CPU E5-2690 V4 @ 2.60GHZ 28 6,274 175,672 Intel
11 11TH GEN CORE I7-11700K @ 3.60GHZ 16 10,674 170,784 Intel
12 CORE I7-10700K CPU @ 3.80GHZ 16 9,504 152,064 Intel
13 XEON CPU E5-2680 V3 @ 2.50GHZ 24 5,751 138,024 Intel
14 CORE I7-10700 CPU @ 2.90GHZ 16 7,559 120,944 Intel
15 RYZEN 7 2700X EIGHT-CORE 16 7,074 113,184 AMD
16 RYZEN 5 3600 6-CORE 12 8,933 107,196 AMD
17 CORE I7-8700 CPU @ 3.20GHZ 12 8,260 99,120 Intel
18 CORE I5-10400 CPU @ 2.90GHZ 12 7,954 95,448 Intel
19 CORE I9-9900K CPU @ 3.60GHZ 16 5,150 82,400 Intel
20 RYZEN 5 2600X SIX-CORE 12 6,237 74,844 AMD
21 RYZEN 3 3100 4-CORE 8 9,282 74,256 AMD
22 CORE I5-10400F CPU @ 2.90GHZ 12 5,619 67,428 Intel
23 CORE I7-6700K CPU @ 4.00GHZ 8 7,459 59,672 Intel
24 11TH GEN CORE I5-11400 @ 2.60GHZ 12 4,763 57,156 Intel
25 RYZEN 5 2600 SIX-CORE 12 4,488 53,856 AMD
26 CORE I5-7600 CPU @ 3.50GHZ 4 10,193 40,772 Intel
27 CORE I5-7400 CPU @ 3.00GHZ 4 8,595 34,380 Intel
28 CORE I5-4590 CPU @ 3.30GHZ 4 7,801 31,204 Intel
29 CORE I5-4570 CPU @ 3.20GHZ 4 7,631 30,524 Intel
30 XEON CPU W3550 @ 3.07GHZ 8 3,139 25,112 Intel
31 CORE I3-7100 CPU @ 3.90GHZ 4 4,843 19,372 Intel
32 XEON CPU E5-2678 V3 @ 2.50GHZ 6 2,835 17,010 Intel
33 CORE I5-7360U CPU @ 2.30GHZ 4 3,428 13,712 Intel
34 CORE I5-7200U CPU @ 2.50GHZ 4 2,937 11,748 Intel
35 CORE I5-3570 CPU @ 3.40GHZ 4 2,743 10,972 Intel
36 CORE I7-2600 CPU @ 3.40GHZ 8 1,361 10,888 Intel
37 CORE M3-7Y30 CPU @ 1.00GHZ 4 2,557 10,228 Intel
38 CORE I5-9300H CPU @ 2.40GHZ 8 1,205 9,640 Intel
39 CORE I3-6006U CPU @ 2.00GHZ 4 2,010 8,040 Intel
40 A10-6700 APU RADEON(TM) HD GRAPHICS 4 1,822 7,288 AMD
41 CORE2 DUO CPU E8400 @ 3.00GHZ 2 1,873 3,746 Intel