PROJECT #17222 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 142,277

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 25 February 2021 23:50:50

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 25 February 2021 23:50:50

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5950X 16-CORE 32 17,877 572,064 AMD
2 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,504 312,192 AMD
3 RYZEN 7 3700X 8-CORE 16 13,867 221,872 AMD
4 RYZEN 7 3800X 8-CORE 16 11,066 177,056 AMD
5 RYZEN 5 3600 6-CORE 12 12,338 148,056 AMD
6 CORE I7-9700K CPU @ 3.60GHZ 8 18,095 144,760 Intel
7 RYZEN 7 2700X EIGHT-CORE 16 5,533 88,528 AMD
8 CORE I3-9100F CPU @ 3.60GHZ 4 12,571 50,284 Intel
9 CORE I5-7600 CPU @ 3.50GHZ 4 9,722 38,888 Intel
10 PENTIUM(R) SILVER N5000 CPU @ 1.10GHZ 4 2,676 10,704 Intel
11 FX-8320 EIGHT-CORE 8 732 5,856 AMD
 

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