PROJECT #17223 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 142,238

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 25 July 2021 18:22:26

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 25 July 2021 18:22:26

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 EPYC 7302 16-CORE 64 13,627 872,128 AMD
2 RYZEN 9 3950X 16-CORE 32 23,907 765,024 AMD
3 RYZEN 9 5950X 16-CORE 32 17,684 565,888 AMD
4 RYZEN 9 5900X 12-CORE 24 20,063 481,512 AMD
5 RYZEN 9 3900X 12-CORE 24 13,988 335,712 AMD
6 RYZEN 7 5800X 8-CORE 16 20,016 320,256 AMD
7 CORE I9-7920X CPU @ 2.90GHZ 24 9,454 226,896 Intel
8 RYZEN 7 3800X 8-CORE 16 12,284 196,544 AMD
9 XEON CPU E5-2667 V2 @ 3.30GHZ 32 5,887 188,384 Intel
10 CORE I9-10900X CPU @ 3.70GHZ 20 9,109 182,180 Intel
11 RYZEN 7 3700X 8-CORE 16 10,815 173,040 AMD
12 CORE I7-9700K CPU @ 3.60GHZ 8 18,697 149,576 Intel
13 RYZEN 5 3600 6-CORE 12 11,933 143,196 AMD
14 RYZEN 7 4800H 16 7,947 127,152 AMD
15 RYZEN 7 2700X EIGHT-CORE 16 6,097 97,552 AMD
16 CORE I5-10400F CPU @ 2.90GHZ 12 7,846 94,152 Intel
17 XEON CPU E5-2620 V2 @ 2.10GHZ 24 3,352 80,448 Intel
18 XEON CPU E5-2690 V2 @ 3.00GHZ 20 3,938 78,760 Intel
19 CORE I7-3840QM CPU @ 2.80GHZ 8 8,489 67,912 Intel
20 CORE I7-4910MQ CPU @ 2.90GHZ 8 8,039 64,312 Intel
21 CORE I7-6700K CPU @ 4.00GHZ 8 7,398 59,184 Intel
22 CORE I7-8705G CPU @ 3.10GHZ 8 7,146 57,168 Intel
23 CORE I5-8400 CPU @ 2.80GHZ 6 8,283 49,698 Intel
24 CORE I5-7600 CPU @ 3.50GHZ 4 10,234 40,936 Intel
25 CORE I3-6006U CPU @ 2.00GHZ 4 2,210 8,840 Intel