PROJECT #17223 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 142,238

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 25 February 2021 23:02:58

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 25 February 2021 23:02:59

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5950X 16-CORE 32 18,804 601,728 AMD
2 RYZEN 9 3900X 12-CORE 24 14,489 347,736 AMD
3 RYZEN 7 5800X 8-CORE 16 20,016 320,256 AMD
4 RYZEN 7 3800X 8-CORE 16 14,308 228,928 AMD
5 CORE I9-7920X CPU @ 2.90GHZ 24 9,454 226,896 Intel
6 RYZEN 7 3700X 8-CORE 16 11,776 188,416 AMD
7 RYZEN 5 3600 6-CORE 12 12,698 152,376 AMD
8 RYZEN 7 2700X EIGHT-CORE 16 6,097 97,552 AMD
9 XEON CPU E5-2690 V2 @ 3.00GHZ 20 4,308 86,160 Intel
10 CORE I7-3840QM CPU @ 2.80GHZ 8 8,489 67,912 Intel
11 CORE I7-4910MQ CPU @ 2.90GHZ 8 8,039 64,312 Intel
12 CORE I3-6006U CPU @ 2.00GHZ 4 2,250 9,000 Intel
 

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