PROJECT #17227 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 57,061

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:10

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:10

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 3950X 16-CORE 32 21,504 688,128 AMD
2 RYZEN 9 5950X 16-CORE 32 18,596 595,072 AMD
3 RYZEN 7 5800X 8-CORE 16 29,615 473,840 AMD
4 RYZEN 7 3800X 8-CORE 16 16,075 257,200 AMD
5 RYZEN 7 3700X 8-CORE 16 13,958 223,328 AMD
6 XEON CPU E5-2690 V4 @ 2.60GHZ 28 5,436 152,208 Intel
7 RYZEN THREADRIPPER 1920X 12-CORE 24 6,019 144,456 AMD
8 CORE I5-10600 CPU @ 3.30GHZ 12 11,435 137,220 Intel
9 CORE I9-10900X CPU @ 3.70GHZ 20 6,847 136,940 Intel
10 RYZEN 5 3600 6-CORE 12 11,068 132,816 AMD
11 RYZEN 5 2600X SIX-CORE 12 8,684 104,208 AMD
12 CORE I5-10400F CPU @ 2.90GHZ 12 7,991 95,892 Intel
13 11TH GEN CORE I5-11400 @ 2.60GHZ 12 6,148 73,776 Intel
14 XEON CPU X5570 @ 2.93GHZ 16 4,393 70,288 Intel
15 CORE I7-6700K CPU @ 4.00GHZ 8 7,629 61,032 Intel
16 CORE I7-5820K CPU @ 3.30GHZ 12 4,158 49,896 Intel
17 RYZEN 3 3200G 4 10,957 43,828 AMD
18 CORE I5-7400 CPU @ 3.00GHZ 4 9,426 37,704 Intel
19 XEON W-10855M CPU @ 2.80GHZ 12 3,027 36,324 Intel
20 CORE I5-7600 CPU @ 3.50GHZ 4 8,273 33,092 Intel
21 CORE I5-6600K CPU @ 3.50GHZ 4 7,435 29,740 Intel
22 CORE I7-2600 CPU @ 3.40GHZ 8 3,029 24,232 Intel
23 CORE I3-6100 CPU @ 3.70GHZ 4 6,003 24,012 Intel
24 CORE I5-3470 CPU @ 3.20GHZ 4 3,492 13,968 Intel
25 CORE I7-7Y75 CPU @ 1.30GHZ 4 2,944 11,776 Intel