PROJECT #17255 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process..

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 84,276

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 22 May 2022 15:22:34

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 22 May 2022 15:22:34

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 7 5800X 8-CORE 16 40,723 651,568 AMD
2 RYZEN 9 3950X 16-CORE 32 16,865 539,680 AMD
3 RYZEN 9 3900 12-CORE 24 21,036 504,864 AMD
4 12TH GEN CORE I7-12700K 20 24,598 491,960 Intel
5 RYZEN 9 5950X 16-CORE 32 13,959 446,688 AMD
6 11TH GEN CORE I9-11900K @ 3.50GHZ 16 27,199 435,184 Intel
7 RYZEN 9 3900XT 12-CORE 24 17,939 430,536 AMD
8 RYZEN 7 5700G 16 24,073 385,168 AMD
9 11TH GEN CORE I7-11700K @ 3.60GHZ 16 23,138 370,208 Intel
10 RYZEN 7 3800X 8-CORE 16 18,702 299,232 AMD
11 12TH GEN CORE I7-12700 20 14,262 285,240 Intel
12 XEON CPU E5-2680 V3 @ 2.50GHZ 24 10,632 255,168 Intel
13 RYZEN 9 5900HS 16 15,234 243,744 AMD
14 XEON CPU E5-2650 V2 @ 2.60GHZ 32 7,116 227,712 Intel
15 RYZEN 5 5600X 6-CORE 12 18,969 227,628 AMD
16 CORE I7-8700 CPU @ 3.20GHZ 12 18,354 220,248 Intel
17 RYZEN 9 5900X 12-CORE 24 8,595 206,280 AMD
18 RYZEN 5 3600 6-CORE 12 15,120 181,440 AMD
19 RYZEN 7 PRO 4750G 16 11,333 181,328 AMD
20 RYZEN 7 2700X EIGHT-CORE 16 11,079 177,264 AMD
21 CORE I7-7700 CPU @ 3.60GHZ 8 16,831 134,648 Intel
22 11TH GEN CORE I5-11400 @ 2.60GHZ 12 11,027 132,324 Intel
23 RYZEN 7 3700X 8-CORE 16 8,161 130,576 AMD
24 CORE I5-9600K CPU @ 3.70GHZ 6 20,842 125,052 Intel
25 CORE I7-10700T CPU @ 2.00GHZ 16 7,210 115,360 Intel
26 CORE I7-4790K CPU @ 4.00GHZ 8 12,161 97,288 Intel
27 CORE I7-6700 CPU @ 3.40GHZ 8 11,224 89,792 Intel
28 XEON CPU E5-2680 0 @ 2.70GHZ 16 5,265 84,240 Intel
29 CORE I9-8950HK CPU @ 2.90GHZ 12 6,992 83,904 Intel
30 CORE I7-4790 CPU @ 3.60GHZ 8 10,174 81,392 Intel
31 RYZEN 5 1600 SIX-CORE 12 6,683 80,196 AMD
32 RYZEN 5 3500X 6-CORE 6 11,805 70,830 AMD
33 XEON CPU E5-2450 0 @ 2.10GHZ 10 6,948 69,480 Intel
34 CORE I5-7400 CPU @ 3.00GHZ 4 16,311 65,244 Intel
35 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 7,772 62,176 Intel
36 CORE I5-6600K CPU @ 3.50GHZ 4 14,944 59,776 Intel
37 CORE I5-6600 CPU @ 3.30GHZ 4 14,399 57,596 Intel
38 CORE I5-6500T CPU @ 2.50GHZ 4 14,225 56,900 Intel
39 CORE I5-4590 CPU @ 3.30GHZ 4 13,424 53,696 Intel
40 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,493 51,944 Intel
41 CORE I5-4570 CPU @ 3.20GHZ 4 12,932 51,728 Intel
42 XEON CPU E3-1245 V2 @ 3.40GHZ 8 4,728 37,824 Intel
43 CORE I5-3570 CPU @ 3.40GHZ 4 8,895 35,580 Intel
44 CORE I3-6100 CPU @ 3.70GHZ 4 8,610 34,440 Intel
45 XEON CPU E31245 @ 3.30GHZ 8 3,938 31,504 Intel
46 CORE I5-4690K CPU @ 3.50GHZ 4 7,029 28,116 Intel
47 CORE I5-3470 CPU @ 3.20GHZ 4 6,203 24,812 Intel
48 CORE I7-8550U CPU @ 1.80GHZ 8 2,947 23,576 Intel
49 CORE I3-3220 CPU @ 3.30GHZ 4 3,241 12,964 Intel
50 CORE I3-6006U CPU @ 2.00GHZ 4 3,238 12,952 Intel
51 CORE I3-3240 CPU @ 3.40GHZ 4 3,237 12,948 Intel
52 CORE I3-3225 CPU @ 3.30GHZ 4 3,100 12,400 Intel
53 FX-4300 QUAD-CORE 4 1,620 6,480 AMD
54 A8-6410 APU 4 410 1,640 AMD