PROJECT #17251 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission. G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site. When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state. Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways. GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions. in this project, we are studying the mechanism of GDP dissociation process.

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 62,335

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:09

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:09

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 XEON CPU E5-2680 V3 @ 2.50GHZ 24 13,398 321,552 Intel
2 CORE I7-5960X CPU @ 3.00GHZ 16 13,858 221,728 Intel
3 CORE I9-9880H CPU @ 2.30GHZ 16 7,473 119,568 Intel
4 CORE I7-6700 CPU @ 3.40GHZ 8 14,907 119,256 Intel
5 11TH GEN CORE I5-11400 @ 2.60GHZ 12 9,467 113,604 Intel
6 XEON CPU X5570 @ 2.93GHZ 16 5,606 89,696 Intel
7 CORE I9-8950HK CPU @ 2.90GHZ 12 6,972 83,664 Intel
8 RYZEN 5 1600 SIX-CORE 12 6,892 82,704 AMD
9 CORE I7-10510U CPU @ 1.80GHZ 8 8,494 67,952 Intel
10 CORE I5-6500T CPU @ 2.50GHZ 4 15,029 60,116 Intel
11 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 6,738 53,904 Intel
12 CORE I7-3770 CPU @ 3.40GHZ 8 5,806 46,448 Intel
13 CORE I7-2600 CPU @ 3.40GHZ 8 4,751 38,008 Intel
14 CORE I5-5200U CPU @ 2.20GHZ 4 4,453 17,812 Intel
15 CORE I3-6006U CPU @ 2.00GHZ 4 3,704 14,816 Intel