PROJECT #17251 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process..

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 62,335

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 03 October 2022 12:16:38

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 03 October 2022 12:16:38

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5950X 16-CORE 32 22,714 726,848 AMD
2 RYZEN 7 5800X 8-CORE 16 38,853 621,648 AMD
3 RYZEN 9 3950X 16-CORE 32 15,735 503,520 AMD
4 RYZEN 9 3900 12-CORE 24 20,482 491,568 AMD
5 11TH GEN CORE I7-11700K @ 3.60GHZ 16 26,096 417,536 Intel
6 11TH GEN CORE I9-11900K @ 3.50GHZ 16 26,024 416,384 Intel
7 RYZEN 7 3800X 8-CORE 16 24,464 391,424 AMD
8 RYZEN 9 3900XT 12-CORE 24 15,229 365,496 AMD
9 12TH GEN CORE I7-12700 20 15,114 302,280 Intel
10 XEON CPU E5-2680 V3 @ 2.50GHZ 24 9,300 223,200 Intel
11 CORE I7-5960X CPU @ 3.00GHZ 16 13,858 221,728 Intel
12 RYZEN 7 PRO 4750G 16 13,089 209,424 AMD
13 CORE I7-8700 CPU @ 3.20GHZ 12 17,193 206,316 Intel
14 RYZEN 5 5600X 6-CORE 12 17,190 206,280 AMD
15 CORE I5-10400 CPU @ 2.90GHZ 12 16,188 194,256 Intel
16 RYZEN 7 3700X 8-CORE 16 10,098 161,568 AMD
17 RYZEN 5 3600 6-CORE 12 12,803 153,636 AMD
18 CORE I7-7700 CPU @ 3.60GHZ 8 17,184 137,472 Intel
19 RYZEN 9 5900HX 16 8,362 133,792 AMD
20 CORE I9-9880H CPU @ 2.30GHZ 16 7,473 119,568 Intel
21 11TH GEN CORE I5-11400 @ 2.60GHZ 12 9,793 117,516 Intel
22 CORE I7-6700 CPU @ 3.40GHZ 8 14,638 117,104 Intel
23 CORE I5-9600K CPU @ 3.70GHZ 6 17,896 107,376 Intel
24 CORE I7-4790K CPU @ 4.00GHZ 8 13,332 106,656 Intel
25 CORE I7-4790 CPU @ 3.60GHZ 8 12,428 99,424 Intel
26 XEON CPU X5570 @ 2.93GHZ 16 5,869 93,904 Intel
27 RYZEN 5 1600 SIX-CORE 12 6,690 80,280 AMD
28 CORE I5-6600K CPU @ 3.50GHZ 4 19,646 78,584 Intel
29 CORE I5-7400 CPU @ 3.00GHZ 4 17,339 69,356 Intel
30 RYZEN 7 4800H 16 4,249 67,984 AMD
31 CORE I7-10510U CPU @ 1.80GHZ 8 8,494 67,952 Intel
32 CORE I5-4570 CPU @ 3.20GHZ 4 16,281 65,124 Intel
33 CORE I5-4590 CPU @ 3.30GHZ 4 16,279 65,116 Intel
34 CORE I5-6500T CPU @ 2.50GHZ 4 15,029 60,116 Intel
35 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 6,794 54,352 Intel
36 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,748 53,984 Intel
37 CORE I5-4670 CPU @ 3.40GHZ 4 13,328 53,312 Intel
38 RYZEN 3 3200G 4 12,556 50,224 AMD
39 CORE I9-8950HK CPU @ 2.90GHZ 12 4,093 49,116 Intel
40 CORE I5-3570 CPU @ 3.40GHZ 4 12,208 48,832 Intel
41 CORE I7-3770 CPU @ 3.40GHZ 8 5,806 46,448 Intel
42 XEON CPU E3-1245 V2 @ 3.40GHZ 8 4,769 38,152 Intel
43 CORE I7-2600 CPU @ 3.40GHZ 8 4,751 38,008 Intel
44 XEON CPU E31245 @ 3.30GHZ 8 4,359 34,872 Intel
45 CORE I5-4690K CPU @ 3.50GHZ 4 8,672 34,688 Intel
46 CORE I7 CPU 975 @ 3.33GHZ 8 3,311 26,488 Intel
47 RYZEN 5 3500X 6-CORE 6 3,660 21,960 AMD
48 CORE I5-3470 CPU @ 3.20GHZ 4 5,341 21,364 Intel
49 CORE I5-5200U CPU @ 2.20GHZ 4 4,453 17,812 Intel
50 CORE I3-3240 CPU @ 3.40GHZ 4 4,102 16,408 Intel
51 CORE I5-4300U CPU @ 1.90GHZ 4 4,083 16,332 Intel
52 CORE I3-6006U CPU @ 2.00GHZ 4 3,775 15,100 Intel
53 CORE I3-3225 CPU @ 3.30GHZ 4 3,240 12,960 Intel
54 CORE I3-3220 CPU @ 3.30GHZ 4 3,125 12,500 Intel
55 A12-9800 RADEON R7, 12 COMPUTE CORES 4C+8G 4 1,192 4,768 AMD
56 CORE2 DUO CPU E8400 @ 3.00GHZ 2 2,284 4,568 Intel