PROJECT #17262 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process..

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 84,276

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 27 June 2022 11:45:23

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 27 June 2022 11:45:23

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5900X 12-CORE 24 33,843 812,232 AMD
2 12TH GEN CORE I7-12700K 20 31,408 628,160 Intel
3 RYZEN 9 3900XT 12-CORE 24 19,399 465,576 AMD
4 RYZEN 7 5700X 8-CORE 16 26,677 426,832 AMD
5 RYZEN 7 3800X 8-CORE 16 14,132 226,112 AMD
6 CORE I7-8700 CPU @ 3.20GHZ 12 14,119 169,428 Intel
7 RYZEN 5 3600 6-CORE 12 12,986 155,832 AMD
8 XEON CPU E5-2698 V4 @ 2.20GHZ 16 7,791 124,656 Intel
9 CORE I3-9100F CPU @ 3.60GHZ 4 22,994 91,976 Intel
10 CORE I5-7400 CPU @ 3.00GHZ 4 15,669 62,676 Intel
11 CORE I7-10510U CPU @ 1.80GHZ 8 7,172 57,376 Intel
12 CORE I5-6600K CPU @ 3.50GHZ 4 14,138 56,552 Intel
13 CORE I5-4590 CPU @ 3.30GHZ 4 12,928 51,712 Intel
14 CORE I5-4570 CPU @ 3.20GHZ 4 11,448 45,792 Intel
15 CORE I5-5200U CPU @ 2.20GHZ 4 4,062 16,248 Intel