PROJECT #17262 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process..

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 84,276

Core: 0xa8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:27

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:27

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5950X 16-CORE 32 23,334 746,688 AMD
2 12TH GEN CORE I7-12700K 20 32,888 657,760 Intel
3 RYZEN 9 5900X 12-CORE 24 27,027 648,648 AMD
4 RYZEN 9 3900 12-CORE 24 24,714 593,136 AMD
5 12TH GEN CORE I9-12900K 24 24,068 577,632 Intel
6 RYZEN 9 3900XT 12-CORE 24 19,424 466,176 AMD
7 RYZEN 7 5800X 8-CORE 16 25,804 412,864 AMD
8 11TH GEN CORE I7-11700K @ 3.60GHZ 16 24,455 391,280 Intel
9 RYZEN 7 5700X 8-CORE 16 21,520 344,320 AMD
10 RYZEN 7 3800X 8-CORE 16 19,308 308,928 AMD
11 CORE I9-9900KF CPU @ 3.60GHZ 16 16,973 271,568 Intel
12 CORE I9-9900 CPU @ 3.10GHZ 16 14,454 231,264 Intel
13 RYZEN 7 PRO 4750G 16 14,362 229,792 AMD
14 CORE I9-9900KS CPU @ 4.00GHZ 16 13,345 213,520 Intel
15 RYZEN 5 5600X 6-CORE 12 15,974 191,688 AMD
16 CORE I7-8700 CPU @ 3.20GHZ 12 15,802 189,624 Intel
17 RYZEN 3 3100 4-CORE 8 23,130 185,040 AMD
18 RYZEN 5 3600 6-CORE 12 14,274 171,288 AMD
19 XEON GOLD 6128 CPU @ 3.40GHZ 12 14,245 170,940 Intel
20 RYZEN 7 3700X 8-CORE 16 10,628 170,048 AMD
21 11TH GEN CORE I5-11400 @ 2.60GHZ 12 11,089 133,068 Intel
22 XEON CPU E5-2698 V4 @ 2.20GHZ 16 7,791 124,656 Intel
23 CORE I7-6700 CPU @ 3.40GHZ 8 15,413 123,304 Intel
24 CORE I3-9100F CPU @ 3.60GHZ 4 22,994 91,976 Intel
25 CORE I9-8950HK CPU @ 2.90GHZ 12 6,500 78,000 Intel
26 RYZEN 5 1600 SIX-CORE 12 5,835 70,020 AMD
27 XEON CPU E5-2680 0 @ 2.70GHZ 16 4,373 69,968 Intel
28 CORE I7-10510U CPU @ 1.80GHZ 8 7,172 57,376 Intel
29 CORE I5-7400 CPU @ 3.00GHZ 4 14,123 56,492 Intel
30 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,994 55,952 Intel
31 CORE I5-4690 CPU @ 3.50GHZ 4 13,094 52,376 Intel
32 CORE I5-6600K CPU @ 3.50GHZ 4 12,899 51,596 Intel
33 CORE I7-3770 CPU @ 3.40GHZ 8 6,188 49,504 Intel
34 CORE I5-4590 CPU @ 3.30GHZ 4 12,374 49,496 Intel
35 APPLE M1 PRO 10 4,739 47,390 Apple
36 CORE I5-4570 CPU @ 3.20GHZ 4 10,928 43,712 Intel
37 CORE I5-3570K CPU @ 3.40GHZ 4 7,591 30,364 Intel
38 CORE I5-5200U CPU @ 2.20GHZ 4 4,062 16,248 Intel
39 CORE I3-6006U CPU @ 2.00GHZ 4 2,880 11,520 Intel