PROJECT #17256 RESEARCH FOR G-PROTEINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process..

PROJECT INFO

Manager(s): Neha Vithani

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 84,276

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:35

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:35

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 3900 12-CORE 24 26,500 636,000 AMD
2 RYZEN 9 3950X 16-CORE 32 18,666 597,312 AMD
3 RYZEN 9 5950X 16-CORE 32 18,661 597,152 AMD
4 RYZEN 7 5800X 8-CORE 16 31,594 505,504 AMD
5 RYZEN 9 3900XT 12-CORE 24 19,121 458,904 AMD
6 RYZEN 9 5900X 12-CORE 24 16,390 393,360 AMD
7 RYZEN 7 3800X 8-CORE 16 23,619 377,904 AMD
8 12TH GEN CORE I7-12700 20 17,659 353,180 Intel
9 RYZEN 7 5700G 16 21,357 341,712 AMD
10 CORE I7-8700 CPU @ 3.20GHZ 12 19,625 235,500 Intel
11 RYZEN 5 3600 6-CORE 12 19,386 232,632 AMD
12 XEON CPU E5-2650 V2 @ 2.60GHZ 32 7,232 231,424 Intel
13 RYZEN 9 5900HS 16 13,899 222,384 AMD
14 XEON CPU E5-2680 V3 @ 2.50GHZ 24 8,964 215,136 Intel
15 RYZEN 7 3700X 8-CORE 16 12,604 201,664 AMD
16 RYZEN 7 PRO 4750G 16 11,282 180,512 AMD
17 CORE I5-8400 CPU @ 2.80GHZ 6 20,957 125,742 Intel
18 CORE I7-4790K CPU @ 4.00GHZ 8 14,567 116,536 Intel
19 CORE I7-6700 CPU @ 3.40GHZ 8 9,751 78,008 Intel
20 XEON CPU E5-2680 0 @ 2.70GHZ 16 4,696 75,136 Intel
21 RYZEN 5 1600 SIX-CORE 12 5,855 70,260 AMD
22 CORE I5-6600K CPU @ 3.50GHZ 4 17,261 69,044 Intel
23 CORE I7-3720QM CPU @ 2.60GHZ 8 8,579 68,632 Intel
24 CORE I5-7400 CPU @ 3.00GHZ 4 16,894 67,576 Intel
25 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 7,910 63,280 Intel
26 CORE I5-6500T CPU @ 2.50GHZ 4 14,836 59,344 Intel
27 CORE I5-4590 CPU @ 3.30GHZ 4 13,667 54,668 Intel
28 CORE I7-4770HQ CPU @ 2.20GHZ 8 5,864 46,912 Intel
29 XEON CPU E3-1240 V2 @ 3.40GHZ 8 5,433 43,464 Intel
30 CORE I5-3570 CPU @ 3.40GHZ 4 9,376 37,504 Intel
31 XEON CPU E5-2620 0 @ 2.00GHZ 12 2,185 26,220 Intel
32 CORE I5-3470 CPU @ 3.20GHZ 4 5,452 21,808 Intel
33 CORE I3-6006U CPU @ 2.00GHZ 4 3,943 15,772 Intel
34 CORE I3-3220 CPU @ 3.30GHZ 4 2,877 11,508 Intel
35 CORE I3-3240 CPU @ 3.40GHZ 4 2,831 11,324 Intel
36 CORE I3-3225 CPU @ 3.30GHZ 4 2,587 10,348 Intel
37 FX-4300 QUAD-CORE 4 1,048 4,192 AMD