PTCH1
Patched 1: A transmembrane protein.
Technical: BiotechnologySignaling Pathway / Hedgehog Signaling
PTCH1 is a key protein in the Hedgehog signaling pathway. It acts as a receptor for Sonic hedgehog (SHH) and regulates cholesterol transport. Dysfunction of PTCH1 can lead to cancer development.
SMO
Smoothened
Technical: BiotechnologySignaling Pathway / Hedgehog Signaling
SMO is a protein that functions downstream of PTCH1 in the Hedgehog pathway. It acts as a signal transducer, promoting cell proliferation and differentiation.
SHH
Sonic Hedgehog
Technical: BiotechnologySignaling Pathway / Hedgehog Signaling
SHH is a signaling molecule that binds to PTCH1, initiating the Hedgehog pathway. It plays crucial roles in development and tissue homeostasis.
Cholesterol
A type of fat (lipid) essential for cell membranes and various biological processes.
Technical: BiotechnologyBiological Process / Membrane Transport
Cholesterol is a vital component of cell membranes, influencing their fluidity and stability. It's also involved in hormone synthesis and other metabolic functions.
Transmembrane Protein
A protein spanning the cell membrane.
Technical: BiotechnologyCellular Biology / Membrane Proteins
Transmembrane proteins are embedded within the cell membrane. They play diverse roles, including transporting molecules, receiving signals, and anchoring cells.
Ciliary Membrane
The membrane surrounding cilia, hair-like structures on some cells.
Technical: BiotechnologyCellular Biology / Cell Structure
Cilia are microscopic projections found on the surface of many cells. The ciliary membrane is a specialized lipid bilayer that forms the outer boundary of these structures.
Cancer
A disease characterized by uncontrolled cell growth.
Clinical: Biotechnology, PharmaceuticalsMedicine / Oncology
Cancer is a group of diseases where abnormal cells grow and spread uncontrollably. This can lead to the formation of tumors and damage to surrounding tissues.
Medulloblastoma
A type of brain cancer originating in the cerebellum.
Clinical: Biotechnology, PharmaceuticalsMedicine / Neuro-Oncology
Medulloblastoma is a highly aggressive childhood brain tumor that arises from cells in the cerebellum. It often requires intensive treatment.
Basal Cell Carcinoma
A common type of skin cancer.
Clinical: Biotechnology, PharmaceuticalsMedicine / Dermatology, Oncology
Basal cell carcinoma is the most prevalent type of skin cancer. It usually appears as a pearly or waxy bump on sun-exposed areas.