Folding project #15213, CANCER research

Research section Research projects and references

Project #15213 overview

Project Summary AI Beta

The project looks at how PTCH1 moves cholesterol around in cells. PTCH1 normally stops a growth signal (called SMO) when there's no special signal (SHH). If PTCH1 doesn't work right, it can cause cancers like medulloblastoma and basal cell carcinoma. Understanding this process could lead to new cancer treatments.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Eric Giavedoni
Institution: University of Illinois at Urbana-Champaign
Website: Open project site

Work unit

Atoms: 181,041
Core: 0x27
Status: Public

Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

PTCH1

Patched homolog 1

Technical: PharmaceuticalsBiotechnology / Genetics

PTCH1 is a gene that provides instructions for making a protein called patched. This protein plays a crucial role in the hedgehog signaling pathway, which is essential for cell growth and development. When cholesterol isn't transported properly by PTCH1, it can lead to problems with this pathway, potentially contributing to cancer.

SMO

Smoothened

Technical: PharmaceuticalsBiotechnology / Genetics

SMO is a protein that acts as a key component in the hedgehog signaling pathway. It's activated when cholesterol is available and helps regulate cell growth and development. Dysregulation of SMO can contribute to cancer.

SHH

Sonic hedgehog

Technical: PharmaceuticalsBiotechnology / Genetics

SHH is a signaling molecule that plays a vital role in embryonic development and tissue regeneration. It binds to PTCH1, triggering the hedgehog signaling pathway, which influences cell growth and differentiation.

hedgehog signaling pathway

A cascade of cellular events that regulates cell growth and differentiation

Technical: PharmaceuticalsBiotechnology / Genetics

The hedgehog signaling pathway is a complex network of interactions within cells. It's activated by the binding of SHH to PTCH1, leading to downstream effects on gene expression and ultimately influencing cell behavior. This pathway plays a crucial role in development and tissue maintenance but can be disrupted in diseases like cancer.

cholesterol transport

The movement of cholesterol molecules within cells and between cells.

Technical: PharmaceuticalsBiotechnology / Molecular Biology

Cholesterol transport is essential for various cellular processes, including cell membrane integrity and signaling pathways. The movement of cholesterol can be regulated by proteins like PTCH1, which plays a role in the hedgehog signaling pathway.

medulloblastoma

An aggressive type of brain tumor that originates in the cerebellum.

Technical: PharmaceuticalsHealthcare / Oncology

Medulloblastoma is a cancerous growth in the cerebellum, a part of the brain responsible for coordination and balance. It's often diagnosed in children and can be very aggressive. Understanding the role of PTCH1 in cholesterol transport and its link to medulloblastoma may lead to new treatment strategies.

basal cell carcinoma

The most common type of skin cancer, arising from the basal cells.

Technical: PharmaceuticalsHealthcare / Dermatology

Basal cell carcinoma is a type of skin cancer that originates in the basal layer of the epidermis. It's often slow-growing and treatable, but understanding its connection to PTCH1 and cholesterol transport may provide insights into prevention and treatment strategies.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	38,092,903	150,000	253.95	0 ^hrs 6 ^mins
2	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	25,642,609	816,912	31.39	0 ^hrs 46 ^mins
3	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	18,500,837	1,144,257	16.17	1 ^hrs 29 ^mins
4	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	16,699,400	596,454	28.00	0 ^hrs 51 ^mins
5	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	16,600,838	150,000	110.67	0 ^hrs 13 ^mins
6	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	15,018,114	752,698	19.95	1 ^hrs 12 ^mins
7	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	13,106,204	828,460	15.82	1 ^hrs 31 ^mins
8	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	11,189,951	150,000	74.60	0 ^hrs 19 ^mins
9	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,852,156	150,000	65.68	0 ^hrs 22 ^mins
10	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	9,556,165	150,000	63.71	0 ^hrs 23 ^mins
11	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	9,486,437	150,000	63.24	0 ^hrs 23 ^mins
12	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	7,572,749	150,000	50.48	0 ^hrs 29 ^mins
13	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	7,362,305	150,000	49.08	0 ^hrs 29 ^mins
14	GeForce RTX 4060 Ti AD104 [GeForce RTX 4060 Ti]	Nvidia	AD104	7,289,281	150,000	48.60	0 ^hrs 30 ^mins
15	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,991,907	150,000	46.61	0 ^hrs 31 ^mins
16	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	6,788,881	353,889	19.18	1 ^hrs 15 ^mins
17	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,413,737	343,589	18.67	1 ^hrs 17 ^mins
18	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	6,071,281	150,000	40.48	0 ^hrs 36 ^mins
19	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,681,213	780,309	7.28	3 ^hrs 18 ^mins

20	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	5,385,142	772,295	6.97	3 ^hrs 27 ^mins
21	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	5,312,141	150,000	35.41	0 ^hrs 41 ^mins
22	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	5,192,955	874,158	5.94	4 ^hrs 2 ^mins
23	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,746,867	150,000	31.65	0 ^hrs 46 ^mins
24	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	4,402,629	150,000	29.35	0 ^hrs 49 ^mins
25	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	3,968,852	150,000	26.46	0 ^hrs 54 ^mins
26	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,511,135	150,000	23.41	1 ^hrs 2 ^mins
27	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,794,798	150,000	18.63	1 ^hrs 17 ^mins
28	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,530,134	150,000	16.87	1 ^hrs 25 ^mins
29	Intel Arc B580 Graphics Battlemage G21 [Intel Arc B580 Graphics]	Intel	Battlemage G21	2,082,033	559,564	3.72	6 ^hrs 27 ^mins
30	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,542,443	150,000	10.28	2 ^hrs 20 ^mins
31	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,382,857	150,000	9.22	2 ^hrs 36 ^mins

Research: CANCER Folding Project #15213

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 15213

GPU PPD Averages

Research: CANCER Folding Project #15213

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages