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Research: CANCER Folding Project #15206

Project #15206 overview

Project Summary AI Beta

This project studies how PTCH1 moves cholesterol around in cells. PTCH1 is important for stopping cancer-causing signals from the hedgehog pathway. If PTCH1 doesn't work right, some cancers can develop. Learning how PTCH1 works could lead to new cancer treatments.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
191,836
Core
0x27
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15206

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:04:53

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 31,015,590 150,000 206.77 0 hrs 7 mins
2 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 23,266,851 839,767 27.71 0 hrs 52 mins
3 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 17,521,529 150,000 116.81 0 hrs 12 mins
4 GeForce RTX 4080 SUPER
AD103 [GeForce RTX 4080 SUPER]		 Nvidia AD103 15,344,174 643,704 23.84 1 hrs 0 mins
5 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 14,993,287 424,587 35.31 0 hrs 41 mins
6 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]		 Nvidia AD104 12,239,431 824,840 14.84 1 hrs 37 mins
7 GeForce RTX 4070 SUPER
AD104 [GeForce RTX 4070 SUPER]		 Nvidia AD104 11,496,978 405,617 28.34 0 hrs 51 mins
8 GeForce RTX 4060 Ti
AD104 [GeForce RTX 4060 Ti]		 Nvidia AD104 10,747,640 150,000 71.65 0 hrs 20 mins
9 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 9,765,203 378,194 25.82 0 hrs 56 mins
10 GeForce RTX 4070 Ti SUPER
AD103 [GeForce RTX 4070 Ti SUPER]		 Nvidia AD103 9,222,241 150,000 61.48 0 hrs 23 mins
11 GeForce RTX 3090
GA102 [GeForce RTX 3090]		 Nvidia GA102 9,195,952 150,000 61.31 0 hrs 23 mins
12 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 8,684,441 150,000 57.90 0 hrs 25 mins
13 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]		 Nvidia GA102 8,498,361 150,000 56.66 0 hrs 25 mins
14 Radeon RX 7900XT/XTX/GRE
Navi 31 [Radeon RX 7900XT/XTX/GRE]		 AMD Navi 31 7,949,070 150,000 52.99 0 hrs 27 mins
15 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448		 Nvidia TU102 6,422,378 150,000 42.82 0 hrs 34 mins
16 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]		 Nvidia GA104 6,333,196 150,000 42.22 0 hrs 34 mins
17 GeForce RTX 3080
GA102 [GeForce RTX 3080]		 Nvidia GA102 5,496,125 488,702 11.25 2 hrs 8 mins
18 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448		 Nvidia TU102 5,467,282 150,000 36.45 0 hrs 40 mins
19 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]		 Nvidia GA104 5,462,275 527,404 10.36 2 hrs 19 mins
20 Radeon RX 9070(XT)
Navi 48 [Radeon RX 9070(XT)]		 AMD Navi 48 4,857,026 434,145 11.19 2 hrs 9 mins
21 GeForce RTX 4060 Ti
AD106 [GeForce RTX 4060 Ti]		 Nvidia AD106 4,307,076 898,552 4.79 5 hrs 0 mins
22 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]		 Nvidia GA104 3,882,061 150,000 25.88 0 hrs 56 mins
23 Radeon RX 6800(XT)/6900XT
Navi 21 [Radeon RX 6800(XT)/6900XT]		 AMD Navi 21 3,697,696 150,000 24.65 0 hrs 58 mins
24 GeForce RTX 4060
AD107 [GeForce RTX 4060]		 Nvidia AD107 3,415,686 150,000 22.77 1 hrs 3 mins
25 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]		 AMD Navi 21 3,338,875 150,000 22.26 1 hrs 5 mins
26 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218		 Nvidia TU104 3,197,819 643,494 4.97 4 hrs 50 mins
27 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]		 Nvidia GA106 2,813,561 305,499 9.21 2 hrs 36 mins
28 GeForce RTX 3060
GA104 [GeForce RTX 3060]		 Nvidia GA104 2,299,227 150,000 15.33 1 hrs 34 mins
29 Radeon RX 6700(XT)/6800M
Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]		 AMD Navi 22 XT-XL 1,375,563 150,000 9.17 2 hrs 37 mins
30 Radeon RX 6650 XT
Navi 23 [Radeon RX 6650 XT]		 AMD Navi 23 1,117,467 150,000 7.45 3 hrs 13 mins