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Research: CANCER Folding Project #15211

Project #15211 overview

Project Summary AI Beta

This project looks at how a protein called PTCH1 moves cholesterol around in cells. PTCH1 helps control cell growth, and if it doesn't work right, it can lead to cancer. By understanding how PTCH1 works, scientists hope to find new ways to treat cancers like medulloblastoma and basal cell carcinoma.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
179,406
Core
0x27
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15211

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:04:48

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 38,788,114 150,000 258.59 0 hrs 6 mins
2 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 25,735,804 1,150,194 22.38 1 hrs 4 mins
3 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 19,319,200 150,000 128.79 0 hrs 11 mins
4 GeForce RTX 4080 SUPER
AD103 [GeForce RTX 4080 SUPER]		 Nvidia AD103 16,830,940 519,350 32.41 0 hrs 44 mins
5 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 14,103,239 309,404 45.58 0 hrs 32 mins
6 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 13,318,116 332,264 40.08 0 hrs 36 mins
7 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]		 Nvidia AD104 13,303,022 879,587 15.12 1 hrs 35 mins
8 GeForce RTX 4070 SUPER
AD104 [GeForce RTX 4070 SUPER]		 Nvidia AD104 12,686,582 150,000 84.58 0 hrs 17 mins
9 GeForce RTX 4070 Ti SUPER
AD103 [GeForce RTX 4070 Ti SUPER]		 Nvidia AD103 12,239,670 150,000 81.60 0 hrs 18 mins
10 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 9,657,430 150,000 64.38 0 hrs 22 mins
11 GeForce RTX 3090
GA102 [GeForce RTX 3090]		 Nvidia GA102 8,809,584 617,087 14.28 1 hrs 41 mins
12 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]		 Nvidia GA102 8,673,686 150,000 57.82 0 hrs 25 mins
13 GeForce RTX 4070
AD104 [GeForce RTX 4070]		 Nvidia AD104 7,563,168 150,000 50.42 0 hrs 29 mins
14 GeForce RTX 5060 Ti
GB206 [GeForce RTX 5060 Ti]		 Nvidia GB206 7,052,434 150,000 47.02 0 hrs 31 mins
15 Radeon RX 7900XT/XTX/GRE
Navi 31 [Radeon RX 7900XT/XTX/GRE]		 AMD Navi 31 6,942,197 150,000 46.28 0 hrs 31 mins
16 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]		 Nvidia GA104 6,621,379 150,000 44.14 0 hrs 33 mins
17 GeForce RTX 3080
GA102 [GeForce RTX 3080]		 Nvidia GA102 5,941,802 393,278 15.11 1 hrs 35 mins
18 GeForce RTX 4060 Ti
AD106 [GeForce RTX 4060 Ti]		 Nvidia AD106 5,767,654 823,108 7.01 3 hrs 26 mins
19 GeForce RTX 3070
GA104 [GeForce RTX 3070]		 Nvidia GA104 5,107,343 752,443 6.79 3 hrs 32 mins
20 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]		 Nvidia GA104 4,193,453 150,000 27.96 0 hrs 52 mins
21 Radeon RX 9070(XT)
Navi 48 [Radeon RX 9070(XT)]		 AMD Navi 48 3,829,910 294,872 12.99 1 hrs 51 mins
22 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]		 Nvidia GA104 3,627,577 150,000 24.18 0 hrs 60 mins
23 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]		 AMD Navi 21 3,521,644 150,000 23.48 1 hrs 1 mins
24 GeForce RTX 4060
AD107 [GeForce RTX 4060]		 Nvidia AD107 3,322,014 150,000 22.15 1 hrs 5 mins
25 Radeon RX 6800(XT)/6900XT
Navi 21 [Radeon RX 6800(XT)/6900XT]		 AMD Navi 21 3,189,284 521,978 6.11 3 hrs 56 mins
26 GeForce RTX 2070
TU106 [GeForce RTX 2070]		 Nvidia TU106 2,873,332 608,348 4.72 5 hrs 5 mins