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Research: CANCER Folding Project #15217

Project #15217 overview

Project Summary AI Beta

This project looks at how PTCH1 moves cholesterol in cells. PTCH1 keeps cancer-causing signals in check, but if it doesn't move cholesterol right, it can lead to cancers like medulloblastoma and basal cell carcinoma. Understanding this process could help us develop new cancer treatments.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
185,941
Core
0x27
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15217

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:04:42

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 35,869,590 150,000 239.13 0 hrs 6 mins
2 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 20,942,580 872,302 24.01 0 hrs 60 mins
3 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 18,258,601 150,000 121.72 0 hrs 12 mins
4 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 16,670,198 702,533 23.73 1 hrs 1 mins
5 GeForce RTX 4080 SUPER
AD103 [GeForce RTX 4080 SUPER]		 Nvidia AD103 16,352,761 710,653 23.01 1 hrs 3 mins
6 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 14,016,118 329,541 42.53 0 hrs 34 mins
7 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]		 Nvidia AD104 12,833,067 917,970 13.98 1 hrs 43 mins
8 GeForce RTX 4070 Ti SUPER
AD103 [GeForce RTX 4070 Ti SUPER]		 Nvidia AD103 11,115,156 150,000 74.10 0 hrs 19 mins
9 GeForce RTX 4070 SUPER
AD104 [GeForce RTX 4070 SUPER]		 Nvidia AD104 10,848,976 150,000 72.33 0 hrs 20 mins
10 GeForce RTX 3090
GA102 [GeForce RTX 3090]		 Nvidia GA102 10,080,144 941,724 10.70 2 hrs 15 mins
11 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]		 Nvidia GA102 9,772,148 150,000 65.15 0 hrs 22 mins
12 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]		 Nvidia GA102 9,487,806 150,000 63.25 0 hrs 23 mins
13 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 8,664,515 150,000 57.76 0 hrs 25 mins
14 GeForce RTX 4070
AD104 [GeForce RTX 4070]		 Nvidia AD104 8,214,531 150,000 54.76 0 hrs 26 mins
15 GeForce RTX 5060 Ti
GB206 [GeForce RTX 5060 Ti]		 Nvidia GB206 7,033,865 150,000 46.89 0 hrs 31 mins
16 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448		 Nvidia TU102 6,827,614 150,000 45.52 0 hrs 32 mins
17 Radeon RX 7900XT/XTX/GRE
Navi 31 [Radeon RX 7900XT/XTX/GRE]		 AMD Navi 31 6,755,423 150,000 45.04 0 hrs 32 mins
18 GeForce RTX 3080
GA102 [GeForce RTX 3080]		 Nvidia GA102 6,369,816 614,306 10.37 2 hrs 19 mins
19 GeForce RTX 3060
GA104 [GeForce RTX 3060]		 Nvidia GA104 6,319,817 150,000 42.13 0 hrs 34 mins
20 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]		 Nvidia GA104 6,105,652 150,000 40.70 0 hrs 35 mins
21 GeForce RTX 4060 Ti
AD104 [GeForce RTX 4060 Ti]		 Nvidia AD104 6,022,634 150,000 40.15 0 hrs 36 mins
22 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448		 Nvidia TU102 5,736,828 150,000 38.25 0 hrs 38 mins
23 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]		 Nvidia GA104 5,670,293 150,000 37.80 0 hrs 38 mins
24 GeForce RTX 4060 Ti
AD106 [GeForce RTX 4060 Ti]		 Nvidia AD106 5,286,108 828,503 6.38 3 hrs 46 mins
25 GeForce RTX 3070
GA104 [GeForce RTX 3070]		 Nvidia GA104 4,730,710 467,010 10.13 2 hrs 22 mins
26 Radeon RX 9070(XT)
Navi 48 [Radeon RX 9070(XT)]		 AMD Navi 48 4,720,282 257,168 18.35 1 hrs 18 mins
27 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]		 AMD Navi 21 4,072,475 150,000 27.15 0 hrs 53 mins
28 Radeon RX 6800(XT)/6900XT
Navi 21 [Radeon RX 6800(XT)/6900XT]		 AMD Navi 21 3,757,214 538,796 6.97 3 hrs 27 mins
29 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]		 Nvidia GA104 3,533,459 150,000 23.56 1 hrs 1 mins
30 GeForce RTX 4060
AD107 [GeForce RTX 4060]		 Nvidia AD107 3,390,822 150,000 22.61 1 hrs 4 mins
31 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218		 Nvidia TU104 3,325,199 654,865 5.08 4 hrs 44 mins
32 Intel Arc B580 Graphics
Battlemage G21 [Intel Arc B580 Graphics]		 Intel Battlemage G21 3,236,746 150,000 21.58 1 hrs 7 mins
33 GeForce RTX 2070
TU106 [GeForce RTX 2070]		 Nvidia TU106 2,867,423 599,513 4.78 5 hrs 1 mins
34 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]		 Nvidia GA104 2,668,728 150,000 17.79 1 hrs 21 mins
35 Radeon RX 6700(XT)/6800M
Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]		 AMD Navi 22 XT-XL 1,326,963 150,000 8.85 2 hrs 43 mins