Folding project #15218, CANCER research

Research section Research projects and references

Project #15218 overview

Project Summary AI Beta

This project looks at how PTCH1 moves cholesterol around in our cells. This protein is important for stopping cancer growth, but when it doesn't work right, cancers like medulloblastoma and basal cell carcinoma can develop. Understanding how PTCH1 works could lead to new treatments for these types of cancer.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Eric Giavedoni
Institution: University of Illinois at Urbana-Champaign
Website: Open project site

Work unit

Atoms: 183,631
Core: 0x27
Status: Public

Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

PTCH1

Patched 1, a transmembrane protein

Technical: BiotechnologySignaling Pathway / Hedgehog Signaling

PTCH1 is a protein that acts as a receptor in the Hedgehog signaling pathway. It helps regulate cell growth and development by inhibiting another protein called SMO when there is no Hedgehog signal present. Dysfunctional PTCH1 can lead to uncontrolled cell growth and contribute to cancer.

SMO

Smoothened

Technical: BiotechnologySignaling Pathway / Hedgehog Signaling

SMO is a protein involved in the Hedgehog signaling pathway. When activated by Hedgehog signals, it promotes cell growth and proliferation. Inhibition of SMO is a potential therapeutic strategy for cancers driven by Hedgehog pathway activation.

SHH

Sonic Hedgehog

Technical: BiotechnologySignaling Pathway / Hedgehog Signaling

SHH is a signaling molecule that plays a crucial role in embryonic development and tissue homeostasis. It activates the Hedgehog pathway, leading to cell proliferation and differentiation. Aberrant SHH signaling is implicated in various cancers.

Cholesterol

A type of lipid essential for cell membrane structure and function

Technical: MedicineBiochemistry / Membrane Transport

Cholesterol is a waxy substance found in all cells. It plays a vital role in building and maintaining cell membranes, regulating hormone production, and aiding in digestion. High cholesterol levels can contribute to heart disease.

Transmembrane Protein

Protein spanning the cell membrane

Technical: BiotechnologyCellular Biology / Membrane Transport

A transmembrane protein is a type of protein that crosses the entire cell membrane. These proteins have essential roles in transporting molecules across the membrane, receiving signals from outside the cell, and maintaining cell structure.

Medulloblastoma

A type of malignant brain tumor

Pathological: MedicineOncology / Brain Tumors

Medulloblastoma is an aggressive childhood brain cancer that originates in the cerebellum. It is characterized by rapid growth and spread, often requiring intensive treatment with surgery, chemotherapy, and radiation therapy.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells

Pathological: MedicineOncology / Skin Cancer

Basal cell carcinoma is the most common type of skin cancer. It typically appears as a pearly or waxy bump and is usually slow-growing. Treatment options include surgical excision, radiation therapy, and topical medications.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	39,721,241	150,000	264.81	0 ^hrs 5 ^mins
2	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	22,810,063	1,020,476	22.35	1 ^hrs 4 ^mins
3	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	19,758,101	150,000	131.72	0 ^hrs 11 ^mins
4	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	16,302,208	668,254	24.40	0 ^hrs 59 ^mins
5	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	15,880,159	595,313	26.68	0 ^hrs 54 ^mins
6	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	15,053,644	738,058	20.40	1 ^hrs 11 ^mins
7	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	12,897,437	751,116	17.17	1 ^hrs 24 ^mins
8	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	11,263,853	150,000	75.09	0 ^hrs 19 ^mins
9	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	9,871,483	934,457	10.56	2 ^hrs 16 ^mins
10	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	9,282,918	418,030	22.21	1 ^hrs 5 ^mins
11	GeForce RTX 5060 Ti GB206 [GeForce RTX 5060 Ti]	Nvidia	GB206	8,560,250	150,000	57.07	0 ^hrs 25 ^mins
12	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	8,378,243	150,000	55.85	0 ^hrs 26 ^mins
13	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	8,358,056	150,000	55.72	0 ^hrs 26 ^mins
14	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	8,263,859	150,000	55.09	0 ^hrs 26 ^mins
15	GeForce RTX 4060 Ti AD104 [GeForce RTX 4060 Ti]	Nvidia	AD104	7,707,894	150,000	51.39	0 ^hrs 28 ^mins
16	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,878,344	150,000	45.86	0 ^hrs 31 ^mins
17	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,949,315	150,000	39.66	0 ^hrs 36 ^mins
18	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,759,000	150,000	38.39	0 ^hrs 38 ^mins
19	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,709,009	150,000	38.06	0 ^hrs 38 ^mins

20	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,046,097	702,522	7.18	3 ^hrs 20 ^mins
21	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	4,425,897	375,182	11.80	2 ^hrs 2 ^mins
22	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	4,150,847	150,000	27.67	0 ^hrs 52 ^mins
23	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,916,773	150,000	26.11	0 ^hrs 55 ^mins
24	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,378,204	654,880	5.16	4 ^hrs 39 ^mins
25	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,217,211	150,000	21.45	1 ^hrs 7 ^mins
26	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	3,043,488	635,081	4.79	5 ^hrs 0 ^mins
27	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,507,998	601,338	4.17	5 ^hrs 45 ^mins
28	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,334,123	150,000	15.56	1 ^hrs 33 ^mins
29	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,256,256	150,000	8.38	2 ^hrs 52 ^mins

Research: CANCER Folding Project #15218

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 15218

GPU PPD Averages

Research: CANCER Folding Project #15218

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages