Folding project #15215, CANCER research

Research section Research projects and references

Project #15215 overview

Project Summary AI Beta

The project relates to how PTCH1 moves cholesterol in cells. This protein helps control a pathway that's important for growth. When it doesn't work right, it can lead to cancers like medulloblastoma and basal cell carcinoma. Understanding how PTCH1 works could help us develop new cancer treatments.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Eric Giavedoni
Institution: University of Illinois at Urbana-Champaign
Website: Open project site

Work unit

Atoms: 186,282
Core: 0x27
Status: Public

Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

PTCH1

Patched homolog 1, a transmembrane protein.

Protein: BiotechnologyCellular Signaling / Hedgehog Pathway

PTCH1 is a protein that plays a crucial role in the hedgehog signaling pathway. It acts as a receptor for the hedgehog signaling molecule and inhibits another protein called SMO when hedgehog signals are absent. This inhibition prevents the activation of downstream pathways involved in cell growth and differentiation.

SMO

Smoothened

Protein: BiotechnologyCellular Signaling / Hedgehog Pathway

SMO is a protein that acts as a key component in the hedgehog signaling pathway. When activated by the hedgehog molecule, SMO triggers a cascade of events leading to cell growth and differentiation. Dysregulation of SMO activity has been implicated in various cancers.

SHH

Sonic Hedgehog

Protein: BiotechnologyCellular Signaling / Hedgehog Pathway

SHH is a signaling protein that plays a critical role in embryonic development and tissue homeostasis. It binds to the PTCH1 receptor, activating the hedgehog pathway and promoting cell growth and differentiation.

cholesterol

A waxy, fat-like substance found in all cells.

Lipid: PharmacologyBiochemistry / Membrane Structure

Cholesterol is a vital component of cell membranes, contributing to their structural integrity and fluidity. It also serves as a precursor for the synthesis of various hormones and bile acids.

cancer

Uncontrolled cell growth and spread.

Disease: HealthcarePathology / Oncology

Cancer is a group of diseases characterized by the uncontrolled proliferation and spread of abnormal cells. It arises from mutations in genes that regulate cell growth and division.

medulloblastoma

A type of brain cancer that originates in the cerebellum.

Disease: HealthcarePathology / Neuro-oncology

Medulloblastoma is a malignant brain tumor that develops in the cerebellum, the part of the brain responsible for coordinating movement and balance. It is the most common pediatric brain tumor.

basal cell carcinoma

A type of skin cancer that arises from the basal cells.

Disease: HealthcarePathology / Dermatology

Basal cell carcinoma is the most common type of skin cancer. It develops from the basal cells, which are found in the deepest layer of the epidermis. It typically appears as a pearly or waxy bump and can be cured with local treatments.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	33,614,903	150,000	224.10	0 ^hrs 6 ^mins
2	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	22,930,521	936,357	24.49	0 ^hrs 59 ^mins
3	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	17,990,821	150,000	119.94	0 ^hrs 12 ^mins
4	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	17,261,227	351,684	49.08	0 ^hrs 29 ^mins
5	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	16,199,318	742,906	21.81	1 ^hrs 6 ^mins
6	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	14,417,550	637,341	22.62	1 ^hrs 4 ^mins
7	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	12,794,428	816,595	15.67	1 ^hrs 32 ^mins
8	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	11,348,348	150,000	75.66	0 ^hrs 19 ^mins
9	GeForce RTX 4060 Ti AD104 [GeForce RTX 4060 Ti]	Nvidia	AD104	10,958,391	150,000	73.06	0 ^hrs 20 ^mins
10	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	10,747,775	683,610	15.72	1 ^hrs 32 ^mins
11	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,605,540	150,000	64.04	0 ^hrs 22 ^mins
12	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	9,486,734	781,271	12.14	1 ^hrs 59 ^mins
13	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	8,861,608	150,000	59.08	0 ^hrs 24 ^mins
14	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	8,572,172	150,000	57.15	0 ^hrs 25 ^mins
15	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	7,135,395	150,000	47.57	0 ^hrs 30 ^mins
16	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,996,645	344,692	20.30	1 ^hrs 11 ^mins
17	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	6,258,975	150,000	41.73	0 ^hrs 35 ^mins
18	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	6,097,073	150,000	40.65	0 ^hrs 35 ^mins
19	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,389,333	510,502	10.56	2 ^hrs 16 ^mins

20	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	5,103,501	365,890	13.95	1 ^hrs 43 ^mins
21	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,862,884	858,681	5.66	4 ^hrs 14 ^mins
22	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,720,634	605,433	7.80	3 ^hrs 5 ^mins
23	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,234,164	150,000	21.56	1 ^hrs 7 ^mins
24	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,526,268	150,000	16.84	1 ^hrs 26 ^mins
25	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,071,810	150,000	13.81	1 ^hrs 44 ^mins

Research: CANCER Folding Project #15215

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 15215

GPU PPD Averages

Research: CANCER Folding Project #15215

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages