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Research: CANCER Folding Project #15210

Project #15210 overview

Project Summary AI Beta

This project looks at how PTCH1 moves cholesterol to block cancer-causing signals. When PTCH1 doesn't work right, cancers like medulloblastoma and basal cell carcinoma can grow. Understanding how PTCH1 works could lead to new cancer treatments.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
187,805
Core
0x27
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15210

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:04:49

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 35,262,855 150,000 235.09 0 hrs 6 mins
2 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 19,660,249 1,089,645 18.04 1 hrs 20 mins
3 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 18,800,463 150,000 125.34 0 hrs 11 mins
4 GeForce RTX 4080 SUPER
AD103 [GeForce RTX 4080 SUPER]		 Nvidia AD103 15,988,993 582,978 27.43 0 hrs 53 mins
5 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 14,424,473 512,676 28.14 0 hrs 51 mins
6 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 12,788,154 395,776 32.31 0 hrs 45 mins
7 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]		 Nvidia AD104 12,015,421 785,480 15.30 1 hrs 34 mins
8 GeForce RTX 4070 Ti SUPER
AD103 [GeForce RTX 4070 Ti SUPER]		 Nvidia AD103 11,696,207 150,000 77.97 0 hrs 18 mins
9 GeForce RTX 4070 SUPER
AD104 [GeForce RTX 4070 SUPER]		 Nvidia AD104 10,663,327 558,029 19.11 1 hrs 15 mins
10 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]		 Nvidia GA102 9,626,027 150,000 64.17 0 hrs 22 mins
11 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]		 Nvidia GA102 9,408,106 150,000 62.72 0 hrs 23 mins
12 GeForce RTX 3090
GA102 [GeForce RTX 3090]		 Nvidia GA102 8,633,911 150,000 57.56 0 hrs 25 mins
13 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 8,615,875 150,000 57.44 0 hrs 25 mins
14 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]		 Nvidia GA102 8,158,117 879,915 9.27 2 hrs 35 mins
15 GeForce RTX 4070
AD104 [GeForce RTX 4070]		 Nvidia AD104 7,099,713 150,000 47.33 0 hrs 30 mins
16 GeForce RTX 5060 Ti
GB206 [GeForce RTX 5060 Ti]		 Nvidia GB206 6,981,758 150,000 46.55 0 hrs 31 mins
17 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448		 Nvidia TU102 6,688,435 150,000 44.59 0 hrs 32 mins
18 Radeon RX 7900XT/XTX/GRE
Navi 31 [Radeon RX 7900XT/XTX/GRE]		 AMD Navi 31 6,206,877 150,000 41.38 0 hrs 35 mins
19 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]		 Nvidia GA104 5,966,792 150,000 39.78 0 hrs 36 mins
20 GeForce RTX 3080
GA102 [GeForce RTX 3080]		 Nvidia GA102 5,839,174 437,695 13.34 1 hrs 48 mins
21 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]		 Nvidia GA104 5,454,640 435,720 12.52 1 hrs 55 mins
22 Radeon RX 9070(XT)
Navi 48 [Radeon RX 9070(XT)]		 AMD Navi 48 4,752,715 150,000 31.68 0 hrs 45 mins
23 GeForce RTX 4060 Ti
AD106 [GeForce RTX 4060 Ti]		 Nvidia AD106 4,473,150 905,932 4.94 4 hrs 52 mins
24 Radeon RX 6800(XT)/6900XT
Navi 21 [Radeon RX 6800(XT)/6900XT]		 AMD Navi 21 3,825,021 150,000 25.50 0 hrs 56 mins
25 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218		 Nvidia TU104 3,300,913 650,299 5.08 4 hrs 44 mins
26 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]		 Nvidia GA104 3,257,051 150,000 21.71 1 hrs 6 mins
27 GeForce RTX 4060
AD107 [GeForce RTX 4060]		 Nvidia AD107 2,998,447 150,000 19.99 1 hrs 12 mins
28 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]		 Nvidia GA106 2,742,049 150,000 18.28 1 hrs 19 mins
29 GeForce RTX 3060
GA104 [GeForce RTX 3060]		 Nvidia GA104 2,600,711 150,000 17.34 1 hrs 23 mins
30 Radeon RX 6700(XT)/6800M
Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]		 AMD Navi 22 XT-XL 1,646,747 150,000 10.98 2 hrs 11 mins