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Research: CANCER Folding Project #15209

Project #15209 overview

Project Summary AI Beta

This project looks at how a protein called PTCH1 moves cholesterol around in cells. This protein normally stops another protein, SMO, from working when it doesn't get the signal SHH. If PTCH1 doesn't work right, it can lead to cancers like medulloblastoma and basal cell carcinoma. Understanding how PTCH1 works could help us find new cancer treatments.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
182,422
Core
0x27
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15209

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:04:50

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 37,189,287 150,000 247.93 0 hrs 6 mins
2 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 26,273,016 921,346 28.52 0 hrs 50 mins
3 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 19,307,262 150,000 128.72 0 hrs 11 mins
4 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 17,648,813 515,354 34.25 0 hrs 42 mins
5 GeForce RTX 4080 SUPER
AD103 [GeForce RTX 4080 SUPER]		 Nvidia AD103 15,942,061 473,631 33.66 0 hrs 43 mins
6 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 13,468,640 324,193 41.55 0 hrs 35 mins
7 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]		 Nvidia AD104 12,966,558 769,957 16.84 1 hrs 26 mins
8 GeForce RTX 4070 Ti SUPER
AD103 [GeForce RTX 4070 Ti SUPER]		 Nvidia AD103 12,062,577 150,000 80.42 0 hrs 18 mins
9 GeForce RTX 4070 SUPER
AD104 [GeForce RTX 4070 SUPER]		 Nvidia AD104 11,169,234 884,262 12.63 1 hrs 54 mins
10 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]		 Nvidia GA102 9,745,916 150,000 64.97 0 hrs 22 mins
11 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 9,140,581 150,000 60.94 0 hrs 24 mins
12 Radeon RX 7900XT/XTX/GRE
Navi 31 [Radeon RX 7900XT/XTX/GRE]		 AMD Navi 31 8,422,599 150,000 56.15 0 hrs 26 mins
13 GeForce RTX 3090
GA102 [GeForce RTX 3090]		 Nvidia GA102 8,197,842 694,617 11.80 2 hrs 2 mins
14 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448		 Nvidia TU102 6,924,430 150,000 46.16 0 hrs 31 mins
15 GeForce RTX 3080
GA102 [GeForce RTX 3080]		 Nvidia GA102 6,914,123 284,280 24.32 0 hrs 59 mins
16 GeForce RTX 4070
AD104 [GeForce RTX 4070]		 Nvidia AD104 6,742,459 150,000 44.95 0 hrs 32 mins
17 GeForce RTX 5060 Ti
GB206 [GeForce RTX 5060 Ti]		 Nvidia GB206 6,626,870 150,000 44.18 0 hrs 33 mins
18 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]		 Nvidia GA104 6,335,610 150,000 42.24 0 hrs 34 mins
19 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]		 Nvidia GA104 5,626,867 619,564 9.08 2 hrs 39 mins
20 GeForce RTX 4060 Ti
AD106 [GeForce RTX 4060 Ti]		 Nvidia AD106 5,092,561 860,654 5.92 4 hrs 3 mins
21 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]		 AMD Navi 21 4,188,527 150,000 27.92 0 hrs 52 mins
22 Radeon RX 9070(XT)
Navi 48 [Radeon RX 9070(XT)]		 AMD Navi 48 4,031,717 266,867 15.11 1 hrs 35 mins
23 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]		 Nvidia GA106 2,767,748 264,734 10.45 2 hrs 18 mins
24 GeForce RTX 4060
AD107 [GeForce RTX 4060]		 Nvidia AD107 2,701,406 150,000 18.01 1 hrs 20 mins
25 GeForce RTX 2070
TU106 [GeForce RTX 2070]		 Nvidia TU106 2,626,709 603,779 4.35 5 hrs 31 mins
26 Radeon RX 6700(XT)/6800M
Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]		 AMD Navi 22 XT-XL 1,187,934 150,000 7.92 3 hrs 2 mins