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Research: CANCER Folding Project #15212

Project #15212 overview

Project Summary AI Beta

This project looks at how PTCH1 moves cholesterol around in our cells. PTCH1 helps control the hedgehog pathway, which is important for growth. Problems with this pathway can lead to cancers like medulloblastoma and basal cell carcinoma. Understanding how PTCH1 works could lead to new cancer treatments.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
178,428
Core
0x27
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15212

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:04:47

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 36,054,031 150,000 240.36 0 hrs 6 mins
2 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 24,828,609 692,872 35.83 0 hrs 40 mins
3 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 18,873,172 150,000 125.82 0 hrs 11 mins
4 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 17,868,192 403,826 44.25 0 hrs 33 mins
5 GeForce RTX 4080 SUPER
AD103 [GeForce RTX 4080 SUPER]		 Nvidia AD103 17,087,950 807,320 21.17 1 hrs 8 mins
6 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 13,360,678 477,755 27.97 0 hrs 51 mins
7 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]		 Nvidia AD104 13,151,685 816,766 16.10 1 hrs 29 mins
8 GeForce RTX 4070 Ti SUPER
AD103 [GeForce RTX 4070 Ti SUPER]		 Nvidia AD103 12,791,157 150,000 85.27 0 hrs 17 mins
9 GeForce RTX 4070 SUPER
AD104 [GeForce RTX 4070 SUPER]		 Nvidia AD104 11,382,224 316,924 35.91 0 hrs 40 mins
10 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]		 Nvidia GA102 10,403,634 150,000 69.36 0 hrs 21 mins
11 GeForce RTX 3090
GA102 [GeForce RTX 3090]		 Nvidia GA102 10,203,000 955,372 10.68 2 hrs 15 mins
12 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]		 Nvidia GA102 10,156,921 150,000 67.71 0 hrs 21 mins
13 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 9,031,366 150,000 60.21 0 hrs 24 mins
14 GeForce RTX 4060 Ti
AD104 [GeForce RTX 4060 Ti]		 Nvidia AD104 8,664,496 150,000 57.76 0 hrs 25 mins
15 GeForce RTX 4070
AD104 [GeForce RTX 4070]		 Nvidia AD104 8,601,821 150,000 57.35 0 hrs 25 mins
16 Radeon RX 7900XT/XTX/GRE
Navi 31 [Radeon RX 7900XT/XTX/GRE]		 AMD Navi 31 8,266,621 150,000 55.11 0 hrs 26 mins
17 GeForce RTX 5060 Ti
GB206 [GeForce RTX 5060 Ti]		 Nvidia GB206 6,928,935 150,000 46.19 0 hrs 31 mins
18 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]		 Nvidia GA104 6,548,265 150,000 43.66 0 hrs 33 mins
19 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]		 Nvidia GA104 6,085,160 150,000 40.57 0 hrs 35 mins
20 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448		 Nvidia TU102 6,035,192 150,000 40.23 0 hrs 36 mins
21 GeForce RTX 3080
GA102 [GeForce RTX 3080]		 Nvidia GA102 5,883,309 489,228 12.03 1 hrs 60 mins
22 GeForce RTX 3070
GA104 [GeForce RTX 3070]		 Nvidia GA104 5,025,923 403,538 12.45 1 hrs 56 mins
23 GeForce RTX 4060 Ti
AD106 [GeForce RTX 4060 Ti]		 Nvidia AD106 4,882,532 930,424 5.25 4 hrs 34 mins
24 Radeon RX 9070(XT)
Navi 48 [Radeon RX 9070(XT)]		 AMD Navi 48 4,880,366 348,825 13.99 1 hrs 43 mins
25 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]		 Nvidia GA104 3,727,756 150,000 24.85 0 hrs 58 mins
26 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]		 AMD Navi 21 3,716,720 150,000 24.78 0 hrs 58 mins
27 GeForce RTX 4060
AD107 [GeForce RTX 4060]		 Nvidia AD107 3,340,490 150,000 22.27 1 hrs 5 mins
28 Radeon RX 6800(XT)/6900XT
Navi 21 [Radeon RX 6800(XT)/6900XT]		 AMD Navi 21 3,310,113 650,735 5.09 4 hrs 43 mins
29 GeForce RTX 3060
GA104 [GeForce RTX 3060]		 Nvidia GA104 2,837,843 150,000 18.92 1 hrs 16 mins
30 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]		 Nvidia GA106 2,703,680 150,000 18.02 1 hrs 20 mins