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Research: CANCER Folding Project #15238

Project #15238 overview

Project Summary AI Beta

The project relates to how PTCH1 moves cholesterol around in cells to control a pathway that's important for growth. When this pathway is messed up, it can lead to cancers like medulloblastoma and basal cell carcinoma. Figuring out how PTCH1 works could help us develop new cancer treatments.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
185,941
Core
0x27
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15238

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Friday, 14 August 2026 15:38:44

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 18,571,871 55,000 337.67 0 hrs 4 mins
2 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 17,137,127 55,000 311.58 0 hrs 5 mins
3 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 Super]		 Nvidia TU104 4,464,350 55,000 81.17 0 hrs 18 mins