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Research: CANCER Folding Project #15232

Project #15232 overview

Project Summary AI Beta

This project looks at how PTCH1 moves cholesterol in our cells. PTCH1 stops cancer-causing signals unless cholesterol is around. If PTCH1 can't move cholesterol, it can lead to cancers like medulloblastoma and basal cell carcinoma. Understanding how PTCH1 works could help us develop new cancer treatments.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
182,422
Core
0x27
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15232

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Friday, 14 August 2026 15:38:50

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 33,811,534 55,000 614.76 0 hrs 2 mins
2 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 18,596,020 125,021 148.74 0 hrs 10 mins
3 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 17,701,621 55,000 321.85 0 hrs 4 mins
4 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 16,899,775 235,082 71.89 0 hrs 20 mins
5 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]		 Nvidia AD104 12,615,706 55,000 229.38 0 hrs 6 mins
6 GeForce RTX 4070 SUPER
AD104 [GeForce RTX 4070 SUPER]		 Nvidia AD104 12,157,205 55,000 221.04 0 hrs 7 mins
7 Radeon RX 9070(XT)
Navi 48 [Radeon RX 9070(XT)]		 AMD Navi 48 11,117,231 55,000 202.13 0 hrs 7 mins
8 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 10,970,982 55,000 199.47 0 hrs 7 mins
9 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 8,757,157 55,000 159.22 0 hrs 9 mins
10 Radeon RX 7900XT/XTX/GRE
Navi 31 [Radeon RX 7900XT/XTX/GRE]		 AMD Navi 31 7,006,186 55,000 127.39 0 hrs 11 mins
11 GeForce RTX 5060 Ti
GB206 [GeForce RTX 5060 Ti]		 Nvidia GB206 6,108,598 55,000 111.07 0 hrs 13 mins
12 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]		 Nvidia GA104 5,935,307 55,000 107.91 0 hrs 13 mins
13 GeForce RTX 3070
GA104 [GeForce RTX 3070]		 Nvidia GA104 5,221,291 385,149 13.56 1 hrs 46 mins
14 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 Super]		 Nvidia TU104 4,635,215 55,000 84.28 0 hrs 17 mins
15 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]		 AMD Navi 21 3,711,369 55,000 67.48 0 hrs 21 mins
16 GeForce RTX 4060
AD107 [GeForce RTX 4060]		 Nvidia AD107 3,589,426 55,000 65.26 0 hrs 22 mins
17 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380		 Nvidia GP102 2,747,261 55,000 49.95 0 hrs 29 mins