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Research: CANCER Folding Project #15236

Project #15236 overview

Project Summary AI Beta

This project looks at how PTCH1 moves cholesterol around in cells. PTCH1 stops a signal called 'hedgehog' when there's no cholesterol, but problems with this can lead to cancer. Figuring out how PTCH1 works could help us treat cancers like medulloblastoma and basal cell carcinoma.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
186,282
Core
0x27
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15236

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Friday, 14 August 2026 15:38:46

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 35,315,897 55,000 642.11 0 hrs 2 mins
2 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 19,003,070 148,754 127.75 0 hrs 11 mins
3 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 17,293,398 292,518 59.12 0 hrs 24 mins
4 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 17,003,039 55,000 309.15 0 hrs 5 mins
5 GeForce RTX 4070 Ti SUPER
AD103 [GeForce RTX 4070 Ti SUPER]		 Nvidia AD103 13,926,333 55,000 253.21 0 hrs 6 mins
6 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]		 Nvidia AD104 13,162,120 289,230 45.51 0 hrs 32 mins
7 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 10,841,154 55,000 197.11 0 hrs 7 mins
8 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]		 Nvidia GA102 10,805,443 494,965 21.83 1 hrs 6 mins
9 GeForce RTX 4070 SUPER
AD104 [GeForce RTX 4070 SUPER]		 Nvidia AD104 10,322,325 55,000 187.68 0 hrs 8 mins
10 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 8,173,452 55,000 148.61 0 hrs 10 mins
11 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448		 Nvidia TU102 7,301,814 436,647 16.72 1 hrs 26 mins
12 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]		 Nvidia GA104 5,870,207 55,000 106.73 0 hrs 13 mins
13 GeForce RTX 4070
AD104 [GeForce RTX 4070]		 Nvidia AD104 5,768,589 402,668 14.33 1 hrs 41 mins
14 TITAN V
GV100 [TITAN V] M 12288		 Nvidia GV100 5,520,620 55,000 100.37 0 hrs 14 mins
15 Radeon RX 9070(XT)
Navi 48 [Radeon RX 9070(XT)]		 AMD Navi 48 5,153,564 55,000 93.70 0 hrs 15 mins
16 GeForce RTX 5070 Ti Mobile
GB205M [GeForce RTX 5070 Ti Mobile]		 Nvidia GB205M 5,141,581 55,000 93.48 0 hrs 15 mins
17 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 Super]		 Nvidia TU104 4,530,542 55,000 82.37 0 hrs 17 mins
18 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]		 AMD Navi 21 4,092,028 55,000 74.40 0 hrs 19 mins
19 GeForce RTX 4060
AD107 [GeForce RTX 4060]		 Nvidia AD107 3,325,127 55,000 60.46 0 hrs 24 mins
20 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]		 Nvidia TU106 2,680,972 311,567 8.60 2 hrs 47 mins
21 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380		 Nvidia GP102 2,623,755 55,000 47.70 0 hrs 30 mins
22 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463		 Nvidia GP104 907,515 55,000 16.50 1 hrs 27 mins
23 Quadro P1000
GP107GL [Quadro P1000]		 Nvidia GP107GL 200,494 131,802 1.52 15 hrs 47 mins