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Research: CANCER Folding Project #15231

Project #15231 overview

Project Summary AI Beta

This project looks at how a protein called PTCH1 moves cholesterol around inside cells. This movement helps control the hedgehog pathway, which is important for growth and development. When this pathway gets messed up, it can lead to cancers like medulloblastoma and basal cell carcinoma. By understanding how PTCH1 works, scientists hope to develop new treatments for these diseases.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
183,405
Core
0x27
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15231

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Friday, 14 August 2026 15:38:51

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 33,423,575 55,000 607.70 0 hrs 2 mins
2 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 18,811,175 101,407 185.50 0 hrs 8 mins
3 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 17,262,676 55,000 313.87 0 hrs 5 mins
4 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 15,433,955 55,000 280.62 0 hrs 5 mins
5 GeForce RTX 4070 Ti SUPER
AD103 [GeForce RTX 4070 Ti SUPER]		 Nvidia AD103 14,165,240 55,000 257.55 0 hrs 6 mins
6 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 10,345,924 55,000 188.11 0 hrs 8 mins
7 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 8,546,012 55,000 155.38 0 hrs 9 mins
8 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]		 Nvidia GA104 5,916,819 55,000 107.58 0 hrs 13 mins
9 Radeon RX 9070(XT)
Navi 48 [Radeon RX 9070(XT)]		 AMD Navi 48 5,178,981 55,000 94.16 0 hrs 15 mins
10 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 Super]		 Nvidia TU104 4,604,654 55,000 83.72 0 hrs 17 mins
11 GeForce RTX 4060
AD107 [GeForce RTX 4060]		 Nvidia AD107 3,209,242 55,000 58.35 0 hrs 25 mins
12 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]		 Nvidia GA106 1,960,881 55,000 35.65 0 hrs 40 mins