PROJECT #19322 RESEARCH FOR AAA-PROTEIN-SUPERFAMILY
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Atomistic insights into AAA+ protein superfamily ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion.

Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis.

Typically, genomes encode approximately ten to several hundred AAA+ family members, each of which is thought to be adapted to specific functional niches that necessitate precise mechanisms of substrate recognition and processing.

The striking adaptive radiation of AAA+ proteins to operate in diverse settings illustrates the versatile utility of the AAA+ domain.

AAA+ proteins typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes.

Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

Rubisco activase (Rca) belongs to the AAA+ superfamily of proteins and it hydrolyzes ATP to ADP.

The complementarity of nucleotide-binding sites between AAA+ interfaces, the mechanism of ATP hydrolysis and the conformational changes activating or deactivating their ATP-binding pocket ensure a functional cycle that creates mechanical force to promote remodeling of substrates.

In this study, we will investigated the ADP/ATP and Mg2+ ion binding mechanism in Rca monomer and homodimers using extensive longtime scale simulations.

We will also try to find the binding pathway for ADP and ATP.

Simulations will also helps to predicts the crucial residues that involved in this binding process..

PROJECT INFO

Manager(s): Rabindranath Paul

Institution: University of Illinois at Urbana-Champaign

PROJECT WORK UNIT SUMMARY

Atoms: 161,472

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 17,125,676 248,204 69.00 0 hrs 21 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 9,086,979 200,560 45.31 0 hrs 32 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,795,103 190,102 41.00 0 hrs 35 mins
4 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,624,839 178,354 37.14 0 hrs 39 mins
5 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,641,799 170,063 33.17 0 hrs 43 mins
6 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,193,626 166,816 31.13 0 hrs 46 mins
7 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,998,066 164,944 30.30 0 hrs 48 mins
8 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 4,574,654 156,406 29.25 0 hrs 49 mins
9 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,491,912 159,301 28.20 0 hrs 51 mins
10 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,074,673 154,554 26.36 0 hrs 55 mins
11 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,642,482 149,285 24.40 0 hrs 59 mins
12 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,583,005 148,110 24.19 0 hrs 60 mins
13 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 3,355,962 144,028 23.30 1 hrs 2 mins
14 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,023,624 139,735 21.64 1 hrs 7 mins
15 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,009,542 139,724 21.54 1 hrs 7 mins
16 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,984,562 139,850 21.34 1 hrs 7 mins
17 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,839,300 137,708 20.62 1 hrs 10 mins
18 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,464,074 131,049 18.80 1 hrs 17 mins
19 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,459,103 129,558 18.98 1 hrs 16 mins
20 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,187,358 126,031 17.36 1 hrs 23 mins
21 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,941,494 120,617 16.10 1 hrs 29 mins
22 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,688,765 138,442 12.20 2 hrs 58 mins
23 Radeon RX 6700/6700XT/6800M
Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]
AMD Navi 22 XT-XL 1,653,081 114,754 14.41 2 hrs 40 mins
24 RTX A2000
GA106 [RTX A2000]
GA106 1,424,996 108,952 13.08 2 hrs 50 mins
25 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,312,309 100,459 13.06 2 hrs 50 mins
26 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,310,937 105,398 12.44 2 hrs 56 mins
27 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,283,166 103,308 12.42 2 hrs 56 mins
28 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,160,127 101,405 11.44 2 hrs 6 mins
29 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,102,239 99,821 11.04 2 hrs 10 mins
30 Radeon RX 6600/6600 XT/6600M
Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 XT-XL 1,099,952 99,521 11.05 2 hrs 10 mins
31 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 1,008,405 97,490 10.34 2 hrs 19 mins
32 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 926,651 89,468 10.36 2 hrs 19 mins
33 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 923,489 93,011 9.93 2 hrs 25 mins
34 Tesla T4
TU104GL [Tesla T4]
Nvidia TU104GL 693,373 85,375 8.12 3 hrs 57 mins
35 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 668,564 84,916 7.87 3 hrs 3 mins
36 RX 5600 OEM/5600XT/5700/5700XT
Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]
Navi 10 516,833 76,452 6.76 4 hrs 33 mins
37 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 490,664 77,466 6.33 4 hrs 47 mins
38 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 465,946 74,645 6.24 4 hrs 51 mins
39 RX 5500/5500M/Pro 5500M
Navi 14 [RX 5500/5500M/Pro 5500M]
Navi 14 443,773 73,800 6.01 4 hrs 59 mins
40 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 359,785 70,375 5.11 5 hrs 42 mins
41 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 288,393 63,465 4.54 5 hrs 17 mins
42 R9 280X/HD 7900/8970 OEM
Tahiti XT [R9 280X/HD 7900/8970 OEM]
Tahiti XT 97,579 44,795 2.18 11 hrs 1 mins
43 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 91,410 43,826 2.09 12 hrs 30 mins
44 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 89,789 43,546 2.06 12 hrs 38 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make