PROJECT #19325 RESEARCH FOR AAA-PROTEIN-SUPERFAMILY
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Atomistic insights into AAA+ protein superfamily ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion.

Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis.

Typically, genomes encode approximately ten to several hundred AAA+ family members, each of which is thought to be adapted to specific functional niches that necessitate precise mechanisms of substrate recognition and processing.

The striking adaptive radiation of AAA+ proteins to operate in diverse settings illustrates the versatile utility of the AAA+ domain.

AAA+ proteins typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes.

Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

Rubisco activase (Rca) belongs to the AAA+ superfamily of proteins and it hydrolyzes ATP to ADP.

The complementarity of nucleotide-binding sites between AAA+ interfaces, the mechanism of ATP hydrolysis and the conformational changes activating or deactivating their ATP-binding pocket ensure a functional cycle that creates mechanical force to promote remodeling of substrates.

In this study, we will investigated the ADP/ATP and Mg2+ ion binding mechanism in Rca monomer and homodimers using extensive longtime scale simulations.

We will also try to find the binding pathway for ADP and ATP.

Simulations will also helps to predicts the crucial residues that involved in this binding process..

PROJECT INFO

Manager(s): Rabindranath Paul

Institution: University of Illinois at Urbana-Champaign

PROJECT WORK UNIT SUMMARY

Atoms: 145,896

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 15,038,114 210,135 71.56 0 hrs 20 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 9,443,030 182,497 51.74 0 hrs 28 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,608,263 170,472 44.63 0 hrs 32 mins
4 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 7,004,145 165,424 42.34 0 hrs 34 mins
5 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 6,563,561 162,525 40.38 0 hrs 36 mins
6 RTX A6000
GA102GL [RTX A6000]
Nvidia GA102GL 6,290,392 161,622 38.92 0 hrs 37 mins
7 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,545,742 149,420 37.12 0 hrs 39 mins
8 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,372,406 152,818 35.16 0 hrs 41 mins
9 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,308,490 151,960 34.93 0 hrs 41 mins
10 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,403,954 142,471 30.91 0 hrs 47 mins
11 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,290,978 140,610 30.52 0 hrs 47 mins
12 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,281,377 141,143 30.33 0 hrs 47 mins
13 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 3,593,327 132,679 27.08 0 hrs 53 mins
14 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,523,256 132,612 26.57 0 hrs 54 mins
15 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,207,093 128,436 24.97 0 hrs 58 mins
16 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,923,691 124,616 23.46 1 hrs 1 mins
17 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,850,980 123,292 23.12 1 hrs 2 mins
18 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,805,194 122,670 22.87 1 hrs 3 mins
19 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,555,205 118,525 21.56 1 hrs 7 mins
20 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,422,487 117,177 20.67 1 hrs 10 mins
21 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,391,789 117,070 20.43 1 hrs 10 mins
22 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,193,581 113,673 19.30 1 hrs 15 mins
23 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,171,596 109,834 19.77 1 hrs 13 mins
24 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,080,183 110,270 18.86 1 hrs 16 mins
25 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 2,022,968 110,478 18.31 1 hrs 19 mins
26 GeForce RTX 2060 12GB
TU106 [GeForce RTX 2060 12GB]
Nvidia TU106 1,826,997 106,473 17.16 1 hrs 24 mins
27 Radeon RX 6700/6700XT/6800M
Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]
AMD Navi 22 XT-XL 1,724,085 104,354 16.52 1 hrs 27 mins
28 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,715,686 110,637 15.51 2 hrs 33 mins
29 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,685,375 102,390 16.46 1 hrs 27 mins
30 Radeon RX 6650XT
Navi 23 [Radeon RX 6650XT]
AMD Navi 23 1,390,423 97,838 14.21 2 hrs 41 mins
31 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,310,007 95,125 13.77 2 hrs 45 mins
32 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,151,549 91,239 12.62 2 hrs 54 mins
33 Radeon RX 6600/6600 XT/6600M
Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 XT-XL 1,128,664 90,752 12.44 2 hrs 56 mins
34 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,114,798 90,481 12.32 2 hrs 57 mins
35 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,093,457 90,996 12.02 2 hrs 60 mins
36 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,091,461 89,359 12.21 2 hrs 58 mins
37 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,057,930 88,579 11.94 2 hrs 1 mins
38 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 1,019,841 88,042 11.58 2 hrs 4 mins
39 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 986,052 84,534 11.66 2 hrs 3 mins
40 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 626,047 74,697 8.38 3 hrs 52 mins
41 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 513,894 70,112 7.33 3 hrs 16 mins
42 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 423,989 65,433 6.48 4 hrs 42 mins
43 P106-090
GP106 [P106-090]
Nvidia GP106 347,140 61,292 5.66 4 hrs 14 mins
44 R9 280X/HD 7900/8970 OEM
Tahiti XT [R9 280X/HD 7900/8970 OEM]
Tahiti XT 204,581 51,487 3.97 6 hrs 2 mins
45 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 87,681 38,832 2.26 11 hrs 38 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make