PROJECT #19320 RESEARCH FOR AAA-PROTEIN-SUPERFAMILY
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Atomistic insights into AAA+ protein superfamily ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion.

Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis.

Typically, genomes encode approximately ten to several hundred AAA+ family members, each of which is thought to be adapted to specific functional niches that necessitate precise mechanisms of substrate recognition and processing.

The striking adaptive radiation of AAA+ proteins to operate in diverse settings illustrates the versatile utility of the AAA+ domain.

AAA+ proteins typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes.

Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

Rubisco activase (Rca) belongs to the AAA+ superfamily of proteins and it hydrolyzes ATP to ADP.

The complementarity of nucleotide-binding sites between AAA+ interfaces, the mechanism of ATP hydrolysis and the conformational changes activating or deactivating their ATP-binding pocket ensure a functional cycle that creates mechanical force to promote remodeling of substrates.

In this study, we will investigated the ADP/ATP and Mg2+ ion binding mechanism in Rca monomer and homodimers using extensive longtime scale simulations.

We will also try to find the binding pathway for ADP and ATP.

Simulations will also helps to predicts the crucial residues that involved in this binding process..

PROJECT INFO

Manager(s): Rabindranath Paul

Institution: University of Illinois at Urbana-Champaign

PROJECT WORK UNIT SUMMARY

Atoms: 138,384

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 13,927,490 185,697 75.00 0 hrs 19 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 9,246,971 172,689 53.55 0 hrs 27 mins
3 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 7,033,872 156,781 44.86 0 hrs 32 mins
4 RTX A6000
GA102GL [RTX A6000]
Nvidia GA102GL 6,672,755 153,139 43.57 0 hrs 33 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 6,479,155 152,769 42.41 0 hrs 34 mins
6 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,273,422 150,766 41.61 0 hrs 35 mins
7 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 6,054,619 149,523 40.49 0 hrs 36 mins
8 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,281,126 143,071 36.91 0 hrs 39 mins
9 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,254,598 143,280 36.67 0 hrs 39 mins
10 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,858,779 139,455 34.84 0 hrs 41 mins
11 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,422,856 134,653 32.85 0 hrs 44 mins
12 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,326,655 133,680 32.37 0 hrs 44 mins
13 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,625,424 127,502 28.43 0 hrs 51 mins
14 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,598,769 125,808 28.61 0 hrs 50 mins
15 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 3,503,902 124,567 28.13 0 hrs 51 mins
16 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,194,145 121,337 26.32 0 hrs 55 mins
17 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,087,939 120,178 25.69 0 hrs 56 mins
18 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,938,797 117,331 25.05 0 hrs 57 mins
19 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,909,123 115,697 25.14 0 hrs 57 mins
20 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,489,514 112,025 22.22 1 hrs 5 mins
21 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,367,622 110,107 21.50 1 hrs 7 mins
22 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,325,849 108,790 21.38 1 hrs 7 mins
23 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 2,041,458 104,472 19.54 1 hrs 14 mins
24 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,012,309 104,687 19.22 1 hrs 15 mins
25 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,824,715 128,189 14.23 2 hrs 41 mins
26 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,665,536 98,185 16.96 1 hrs 25 mins
27 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,303,057 90,275 14.43 2 hrs 40 mins
28 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,232,706 87,397 14.10 2 hrs 42 mins
29 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 1,147,962 86,171 13.32 2 hrs 48 mins
30 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,130,598 85,560 13.21 2 hrs 49 mins
31 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,110,558 85,056 13.06 2 hrs 50 mins
32 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,101,025 84,962 12.96 2 hrs 51 mins
33 Radeon RX 6600/6600 XT/6600M
Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 XT-XL 1,072,873 84,494 12.70 2 hrs 53 mins
34 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 988,959 80,054 12.35 2 hrs 57 mins
35 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 887,489 79,210 11.20 2 hrs 9 mins
36 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 776,291 76,354 10.17 2 hrs 22 mins
37 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 769,247 75,172 10.23 2 hrs 21 mins
38 Tesla T4
TU104GL [Tesla T4]
Nvidia TU104GL 721,524 73,802 9.78 2 hrs 27 mins
39 P106-090
GP106 [P106-090]
Nvidia GP106 335,584 57,502 5.84 4 hrs 7 mins
40 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 265,026 53,179 4.98 5 hrs 49 mins
41 RX Vega M GL
Polaris 22 XL [RX Vega M GL]
Polaris 22 XL 165,972 45,408 3.66 7 hrs 34 mins
42 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 141,795 24,580 5.77 4 hrs 10 mins
43 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 90,361 37,074 2.44 10 hrs 51 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make