PROJECT #19324 RESEARCH FOR AAA-PROTEIN-SUPERFAMILY
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Atomistic insights into AAA+ protein superfamily ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion.

Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis.

Typically, genomes encode approximately ten to several hundred AAA+ family members, each of which is thought to be adapted to specific functional niches that necessitate precise mechanisms of substrate recognition and processing.

The striking adaptive radiation of AAA+ proteins to operate in diverse settings illustrates the versatile utility of the AAA+ domain.

AAA+ proteins typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes.

Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

Rubisco activase (Rca) belongs to the AAA+ superfamily of proteins and it hydrolyzes ATP to ADP.

The complementarity of nucleotide-binding sites between AAA+ interfaces, the mechanism of ATP hydrolysis and the conformational changes activating or deactivating their ATP-binding pocket ensure a functional cycle that creates mechanical force to promote remodeling of substrates.

In this study, we will investigated the ADP/ATP and Mg2+ ion binding mechanism in Rca monomer and homodimers using extensive longtime scale simulations.

We will also try to find the binding pathway for ADP and ATP.

Simulations will also helps to predicts the crucial residues that involved in this binding process..

PROJECT INFO

Manager(s): Rabindranath Paul

Institution: University of Illinois at Urbana-Champaign

PROJECT WORK UNIT SUMMARY

Atoms: 145,896

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 16,219,396 215,426 75.29 0 hrs 19 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 9,290,707 182,436 50.93 0 hrs 28 mins
3 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 7,476,044 169,866 44.01 0 hrs 33 mins
4 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,535,974 160,779 40.65 0 hrs 35 mins
5 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,321,451 155,013 34.33 0 hrs 42 mins
6 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,265,849 149,858 35.14 0 hrs 41 mins
7 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,995,549 148,419 33.66 0 hrs 43 mins
8 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,547,009 142,754 31.85 0 hrs 45 mins
9 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,232,021 140,177 30.19 0 hrs 48 mins
10 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,681,500 134,808 27.31 0 hrs 53 mins
11 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,512,401 132,029 26.60 0 hrs 54 mins
12 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 3,372,085 125,842 26.80 0 hrs 54 mins
13 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,180,994 128,395 24.78 0 hrs 58 mins
14 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,156,164 127,831 24.69 0 hrs 58 mins
15 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,923,273 123,200 23.73 1 hrs 1 mins
16 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,531,356 118,304 21.40 1 hrs 7 mins
17 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,502,456 118,516 21.11 1 hrs 8 mins
18 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,454,679 116,773 21.02 1 hrs 9 mins
19 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,270,920 113,745 19.97 1 hrs 12 mins
20 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,248,829 114,330 19.67 1 hrs 13 mins
21 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,098,944 111,337 18.85 1 hrs 16 mins
22 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,975,332 108,627 18.18 1 hrs 19 mins
23 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,807,022 122,100 14.80 2 hrs 37 mins
24 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,215,068 83,172 14.61 2 hrs 39 mins
25 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,198,005 91,837 13.04 2 hrs 50 mins
26 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,182,581 90,779 13.03 2 hrs 51 mins
27 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,158,430 91,463 12.67 2 hrs 54 mins
28 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,101,792 89,994 12.24 2 hrs 58 mins
29 Radeon RX 6600/6600 XT/6600M
Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 XT-XL 1,100,139 89,766 12.26 2 hrs 57 mins
30 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,079,727 79,445 13.59 2 hrs 46 mins
31 RX 5600 OEM/5600XT/5700/5700XT
Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]
Navi 10 993,710 87,506 11.36 2 hrs 7 mins
32 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 916,867 77,397 11.85 2 hrs 2 mins
33 Tesla T4
TU104GL [Tesla T4]
Nvidia TU104GL 712,390 77,703 9.17 3 hrs 37 mins
34 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 523,876 70,199 7.46 3 hrs 13 mins
35 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 428,487 65,915 6.50 4 hrs 42 mins
36 P106-090
GP106 [P106-090]
Nvidia GP106 356,047 61,681 5.77 4 hrs 9 mins
37 R9 380X/R9 M295X
Tonga XT/Amethyst XT [R9 380X/R9 M295X]
AMD Tonga XT/Amethyst XT 220,285 51,801 4.25 6 hrs 39 mins
38 Vega Mobile 5000 series APU
Cezanne [Vega Mobile 5000 series APU]
AMD Cezanne 53,640 36,749 1.46 16 hrs 27 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make