PROJECT #19319 RESEARCH FOR AAA-PROTEIN-SUPERFAMILY
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Atomistic insights into AAA+ protein superfamily ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion.

Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis.

Typically, genomes encode approximately ten to several hundred AAA+ family members, each of which is thought to be adapted to specific functional niches that necessitate precise mechanisms of substrate recognition and processing.

The striking adaptive radiation of AAA+ proteins to operate in diverse settings illustrates the versatile utility of the AAA+ domain.

AAA+ proteins typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes.

Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

Rubisco activase (Rca) belongs to the AAA+ superfamily of proteins and it hydrolyzes ATP to ADP.

The complementarity of nucleotide-binding sites between AAA+ interfaces, the mechanism of ATP hydrolysis and the conformational changes activating or deactivating their ATP-binding pocket ensure a functional cycle that creates mechanical force to promote remodeling of substrates.

In this study, we will investigated the ADP/ATP and Mg2+ ion binding mechanism in Rca monomer and homodimers using extensive longtime scale simulations.

We will also try to find the binding pathway for ADP and ATP.

Simulations will also helps to predicts the crucial residues that involved in this binding process..

PROJECT INFO

Manager(s): Rabindranath Paul

Institution: University of Illinois at Urbana-Champaign

PROJECT WORK UNIT SUMMARY

Atoms: 162,337

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 14,759,094 237,441 62.16 0 hrs 23 mins
2 GeForce RTX 4080
AD103 [GeForce RTX 4080]
Nvidia AD103 12,608,635 226,084 55.77 0 hrs 26 mins
3 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 8,983,856 201,273 44.64 0 hrs 32 mins
4 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,560,464 178,804 36.69 0 hrs 39 mins
5 RTX A6000
GA102GL [RTX A6000]
Nvidia GA102GL 6,296,365 179,748 35.03 0 hrs 41 mins
6 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,225,789 175,192 35.54 0 hrs 41 mins
7 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,915,619 174,957 33.81 0 hrs 43 mins
8 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,323,860 169,981 31.32 0 hrs 46 mins
9 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,247,858 169,392 30.98 0 hrs 46 mins
10 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,162,878 168,458 30.65 0 hrs 47 mins
11 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,724,725 163,912 28.82 0 hrs 50 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,620,724 148,446 24.39 0 hrs 59 mins
13 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 3,333,599 143,867 23.17 1 hrs 2 mins
14 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,293,340 143,646 22.93 1 hrs 3 mins
15 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,275,634 146,122 22.42 1 hrs 4 mins
16 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,078,778 140,584 21.90 1 hrs 6 mins
17 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,002,408 139,666 21.50 1 hrs 7 mins
18 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,728,556 133,730 20.40 1 hrs 11 mins
19 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,719,308 135,310 20.10 1 hrs 12 mins
20 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,705,644 135,483 19.97 1 hrs 12 mins
21 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,392,695 130,399 18.35 1 hrs 18 mins
22 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,194,322 125,549 17.48 1 hrs 22 mins
23 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,039,961 123,418 16.53 1 hrs 27 mins
24 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,944,540 120,573 16.13 1 hrs 29 mins
25 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,896,569 120,116 15.79 2 hrs 31 mins
26 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,685,685 124,477 13.54 2 hrs 46 mins
27 Radeon RX 6700/6700XT/6800M
Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]
AMD Navi 22 XT-XL 1,559,228 112,351 13.88 2 hrs 44 mins
28 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,234,796 104,531 11.81 2 hrs 2 mins
29 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,167,020 101,924 11.45 2 hrs 6 mins
30 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,139,811 101,435 11.24 2 hrs 8 mins
31 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,095,870 100,005 10.96 2 hrs 11 mins
32 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,069,575 99,403 10.76 2 hrs 14 mins
33 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 997,988 95,851 10.41 2 hrs 18 mins
34 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 954,108 90,561 10.54 2 hrs 17 mins
35 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 418,448 72,372 5.78 4 hrs 9 mins
36 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 364,612 67,933 5.37 4 hrs 28 mins
37 P106-090
GP106 [P106-090]
Nvidia GP106 342,934 68,803 4.98 5 hrs 49 mins
38 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 276,073 62,568 4.41 5 hrs 26 mins
39 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 227,836 63,616 3.58 7 hrs 42 mins
40 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 94,395 43,954 2.15 11 hrs 11 mins
41 Vega Mobile 5000 series APU
Cezanne [Vega Mobile 5000 series APU]
AMD Cezanne 38,822 24,955 1.56 15 hrs 26 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make