PROJECT #19326 RESEARCH FOR AAA-PROTEIN-SUPERFAMILY
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Atomistic insights into AAA+ protein superfamily ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion.

Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis.

Typically, genomes encode approximately ten to several hundred AAA+ family members, each of which is thought to be adapted to specific functional niches that necessitate precise mechanisms of substrate recognition and processing.

The striking adaptive radiation of AAA+ proteins to operate in diverse settings illustrates the versatile utility of the AAA+ domain.

AAA+ proteins typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes.

Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

Rubisco activase (Rca) belongs to the AAA+ superfamily of proteins and it hydrolyzes ATP to ADP.

The complementarity of nucleotide-binding sites between AAA+ interfaces, the mechanism of ATP hydrolysis and the conformational changes activating or deactivating their ATP-binding pocket ensure a functional cycle that creates mechanical force to promote remodeling of substrates.

In this study, we will investigated the ADP/ATP and Mg2+ ion binding mechanism in Rca monomer and homodimers using extensive longtime scale simulations.

We will also try to find the binding pathway for ADP and ATP.

Simulations will also helps to predicts the crucial residues that involved in this binding process..

PROJECT INFO

Manager(s): Rabindranath Paul

Institution: University of Illinois at Urbana-Champaign

PROJECT WORK UNIT SUMMARY

Atoms: 83,337

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 13,282,585 109,614 121.18 0 hrs 12 mins
2 GeForce RTX 4080
AD103 [GeForce RTX 4080]
Nvidia AD103 11,516,661 103,348 111.44 0 hrs 13 mins
3 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 7,680,908 92,521 83.02 0 hrs 17 mins
4 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,031,136 85,026 70.93 0 hrs 20 mins
5 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 5,884,246 85,072 69.17 0 hrs 21 mins
6 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,559,941 79,269 70.14 0 hrs 21 mins
7 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,557,973 77,820 58.57 0 hrs 25 mins
8 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,304,526 76,396 56.34 0 hrs 26 mins
9 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,242,636 75,937 55.87 0 hrs 26 mins
10 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,623,325 72,284 50.13 0 hrs 29 mins
11 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 3,259,839 70,403 46.30 0 hrs 31 mins
12 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,103,990 67,724 45.83 0 hrs 31 mins
13 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 2,934,848 66,842 43.91 0 hrs 33 mins
14 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,904,176 67,226 43.20 0 hrs 33 mins
15 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,878,987 67,031 42.95 0 hrs 34 mins
16 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 2,844,452 65,944 43.13 0 hrs 33 mins
17 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,794,083 65,960 42.36 0 hrs 34 mins
18 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 2,743,257 64,298 42.66 0 hrs 34 mins
19 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 2,711,342 65,637 41.31 0 hrs 35 mins
20 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,613,809 64,620 40.45 0 hrs 36 mins
21 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,462,130 62,985 39.09 0 hrs 37 mins
22 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 2,428,766 63,914 38.00 0 hrs 38 mins
23 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,257,927 61,542 36.69 0 hrs 39 mins
24 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,003,544 59,521 33.66 0 hrs 43 mins
25 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,894,994 58,842 32.20 0 hrs 45 mins
26 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,606,361 55,452 28.97 0 hrs 50 mins
27 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 1,470,120 53,090 27.69 0 hrs 52 mins
28 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,409,988 51,680 27.28 0 hrs 53 mins
29 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,251,221 49,505 25.27 0 hrs 57 mins
30 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,226,222 50,303 24.38 0 hrs 59 mins
31 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,213,589 50,079 24.23 0 hrs 59 mins
32 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 1,102,925 48,287 22.84 1 hrs 3 mins
33 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,055,652 47,999 21.99 1 hrs 5 mins
34 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 924,562 45,370 20.38 1 hrs 11 mins
35 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 879,228 44,792 19.63 1 hrs 13 mins
36 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 840,171 40,303 20.85 1 hrs 9 mins
37 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 830,481 43,622 19.04 1 hrs 16 mins
38 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 750,511 41,894 17.91 1 hrs 20 mins
39 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 691,065 41,516 16.65 1 hrs 27 mins
40 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 313,735 31,786 9.87 2 hrs 26 mins
41 RX Vega M GL
Polaris 22 XL [RX Vega M GL]
Polaris 22 XL 153,115 25,095 6.10 4 hrs 56 mins
42 R9 280X/HD 7900/8970 OEM
Tahiti XT [R9 280X/HD 7900/8970 OEM]
Tahiti XT 101,175 21,364 4.74 5 hrs 4 mins
43 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 89,883 21,217 4.24 6 hrs 40 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make