PROJECT #19327 RESEARCH FOR AAA-PROTEIN-SUPERFAMILY
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Atomistic insights into AAA+ protein superfamily ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion.

Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis.

Typically, genomes encode approximately ten to several hundred AAA+ family members, each of which is thought to be adapted to specific functional niches that necessitate precise mechanisms of substrate recognition and processing.

The striking adaptive radiation of AAA+ proteins to operate in diverse settings illustrates the versatile utility of the AAA+ domain.

AAA+ proteins typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes.

Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

Rubisco activase (Rca) belongs to the AAA+ superfamily of proteins and it hydrolyzes ATP to ADP.

The complementarity of nucleotide-binding sites between AAA+ interfaces, the mechanism of ATP hydrolysis and the conformational changes activating or deactivating their ATP-binding pocket ensure a functional cycle that creates mechanical force to promote remodeling of substrates.

In this study, we will investigated the ADP/ATP and Mg2+ ion binding mechanism in Rca monomer and homodimers using extensive longtime scale simulations.

We will also try to find the binding pathway for ADP and ATP.

Simulations will also helps to predicts the crucial residues that involved in this binding process..

PROJECT INFO

Manager(s): Rabindranath Paul

Institution: University of Illinois at Urbana-Champaign

PROJECT WORK UNIT SUMMARY

Atoms: 83,337

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 9,724,051 81,043 119.99 0 hrs 12 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 7,522,804 91,566 82.16 0 hrs 18 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,569,918 87,000 75.52 0 hrs 19 mins
4 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 5,790,585 83,501 69.35 0 hrs 21 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,684,536 83,460 68.11 0 hrs 21 mins
6 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,336,180 81,999 65.08 0 hrs 22 mins
7 RTX A6000
GA102GL [RTX A6000]
Nvidia GA102GL 5,335,111 81,903 65.14 0 hrs 22 mins
8 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,900,889 79,841 61.38 0 hrs 23 mins
9 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,492,792 76,143 59.00 0 hrs 24 mins
10 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,806,040 72,366 52.59 0 hrs 27 mins
11 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,462,789 70,940 48.81 0 hrs 30 mins
12 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 3,179,617 95,224 33.39 0 hrs 43 mins
13 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,101,800 67,292 46.09 0 hrs 31 mins
14 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 2,999,307 67,624 44.35 0 hrs 32 mins
15 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,824,101 66,828 42.26 0 hrs 34 mins
16 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 2,772,436 65,783 42.15 0 hrs 34 mins
17 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 2,746,465 66,580 41.25 0 hrs 35 mins
18 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,722,975 65,356 41.66 0 hrs 35 mins
19 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,710,338 65,589 41.32 0 hrs 35 mins
20 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,599,445 64,370 40.38 0 hrs 36 mins
21 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,358,768 62,067 38.00 0 hrs 38 mins
22 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,141,773 61,006 35.11 0 hrs 41 mins
23 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,099,220 60,255 34.84 0 hrs 41 mins
24 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,999,933 58,607 34.12 0 hrs 42 mins
25 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 1,983,313 58,455 33.93 0 hrs 42 mins
26 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,683,484 55,926 30.10 0 hrs 48 mins
27 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,207,345 50,166 24.07 0 hrs 60 mins
28 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,196,796 49,649 24.11 0 hrs 60 mins
29 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,158,193 48,928 23.67 1 hrs 1 mins
30 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,116,606 47,767 23.38 1 hrs 2 mins
31 Radeon RX 6600/6600 XT/6600M
Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 XT-XL 1,065,665 47,781 22.30 1 hrs 5 mins
32 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,010,088 47,814 21.13 1 hrs 8 mins
33 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 866,902 44,520 19.47 1 hrs 14 mins
34 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 823,202 39,365 20.91 1 hrs 9 mins
35 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 794,911 43,745 18.17 1 hrs 19 mins
36 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 604,161 39,458 15.31 2 hrs 34 mins
37 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 486,078 21,862 22.23 1 hrs 5 mins
38 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 463,577 36,519 12.69 2 hrs 53 mins
39 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 324,977 31,359 10.36 2 hrs 19 mins
40 R9 380X/R9 M295X
Tonga XT/Amethyst XT [R9 380X/R9 M295X]
AMD Tonga XT/Amethyst XT 166,920 21,739 7.68 3 hrs 8 mins
41 RX Vega M GL
Polaris 22 XL [RX Vega M GL]
Polaris 22 XL 155,371 25,264 6.15 4 hrs 54 mins
42 GeForce MX450
TU117M [GeForce MX450]
Nvidia TU117M 148,402 25,166 5.90 4 hrs 4 mins
43 R9 280X/HD 7900/8970 OEM
Tahiti XT [R9 280X/HD 7900/8970 OEM]
Tahiti XT 138,849 23,966 5.79 4 hrs 9 mins
44 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 99,899 21,869 4.57 5 hrs 15 mins
45 Vega Mobile 5000 series APU
Cezanne [Vega Mobile 5000 series APU]
AMD Cezanne 90,953 20,012 4.54 5 hrs 17 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make